Her-2 receptor has already been identified as one of the most important biological markers of some malignant tumors,and also plays an important role in the biological behavior of those tumor cells.The over-expression of Her-2 receptor is associated with radioresistance of various tumor cells,and thus an antibody to Her-2/neu receptor can probably function as a radiosensitizer.In this review,we summarized some advances in the molecular mechanism and clinical aspects of the relationship between Her-2 and cellular radiosensitivity.

Arthropathy, Neurogenic ; Child ; Coxa Vara ; Hand Deformities, Congenital ; Humans ; Male ; Synovitis

Adult ; Antilymphocyte Serum ; therapeutic use ; Female ; Graft vs Host Disease ; prevention & control ; Hematopoietic Stem Cell Mobilization ; methods ; Humans ; Immunosuppressive Agents ; therapeutic use ; Male ; Middle Aged ; Transplantation Conditioning ; methods ; Vidarabine ; analogs & derivatives ; therapeutic use

AIM: To explore the effect of different corneal incision size on change in tear function after phacoemulsification cataract surgery in type 2 diabetics.
●METHODS:One hundred and fifty patients with type 2 diabetes (150 eyes) from Jan. 2015 to Oct. 2015 in our hospital were enrolled. The patients were randomly divided into two groups. Seventy-five patients (75 eyes) in group A: coaxial 2. 2mm micro - incision phacoemulsification cataract extraction and intraocular lens (lOL) implantation; seventy-five patients (75 eyes) in group B:the conventional coaxial 3. 0mm small incision phacoemulsification cataract extraction and lOL implantation. The difference of demographic characteristics between two groups were insignificant. The ocular surface disease index ( OSDl ) , corneal sensation, break up time (BUT) and Schirmer′sltest(Slt) were examined preoperatively and 1wk, 1, 3 and 6mo postoperatively.
●RESULTS:At 1wk, 1 and 3mo postoperatively, the OSDl score in two groups increased and the OSDl score of group B was significantly higher than those of group A and the differences were statistically significant ( all P<0. 05 ) . The corneal sensation in two groups decreased after operations and the corneal sensation of group B was significantly lower than those of group A and the differences were statistically significant (all P<0. 05). The Slt in two groups decreased after operations and the Slt of group B was significantly lower than those of group A and the differences were statistically significant (all P<0. 05). At 1wk and 1mo postoperatively, the BUT in two groups decreased after operations and the BUT of group B was significantly lower than those of group A and the differences were statistically significant (all P<0. 05). At 6mo postoperatively, no significant change was found in the OSDl score, corneal sensation, BUT and S l t of group A compared with preoperatively (all P>0. 05). At 6mo postoperatively, the differences of OSDl score and corneal sensation in group B were statistically significant compared with preoperatively ( all P< 0. 05 ) while no significant change was found in the BUT and S l t of group B (all P>0. 05).
●CONCLUSION:Phacoemulsification surgery with 2. 2mm corneal micro-incision has less effect on change in tear function comparing to the 3. 0 mm incision control, which can be applied particularly in patients with type 2 diabetes.

OBJECTIVETo evaluate the effects of different polishing methods on surface roughness of pure titanium castings.

METHODS35 pure titanium castings were devided into 7 groups, used for control, mechanic polishing and electrolytic polishing, respectively. Surface roughness (Ra value) of each castings was measured with a profilometer. Surface microstructure was studied by a scaning electron microscopy, and the weight loss (Wt%) and height loss on unit area (H) before and after polishing was calculated.

RESULTSThe effects of mechanic polishing with aluminium oxide or chromium oxide were acceptable. Surface smoothness was improved with acid treatment followed by electrolytic polishing.

CONCLUSIONAluminium oxide and chromium oxide can be used in mechanic polishing of pure titanium castings, and improvement should be made on electrolytic polishing methods.

AIM: To compare the components of crude and processed Dryopteris Crassirhizoma Nakai by different kinds of cutting and carbonizing. METHODS: UV-spectrometry was utilized to analyze the yield and extract content. RESULTS: Dryopteris Crassirhizoma Nakai after being curshed has the maximum in the yield, the total phenol of carbonized products, the water extract and alcohol extract. CONCLUSION: There are significant differences in intrinsic quality among various processed products of Dryopteris Crassirhizoma nakai, among them the crushed one has the highest quality, which conforms to China pharmacopeia 2000 VolⅠ.

90 without intestinal canal whirl sign was used as the diagnostic standard for whirl sign.Two experienced physicians evaluated the mesenteric vessel whirl sign and its morphological characteristics(including its site,rotation direction,rotation angle,distance between the start and end points of rotating vessels,and rotation radius) and associated signs.The difference in characteristics of whirl sign was compared between volvulus and non-volvulus patients.Results Mesenteric vessel whirl sign was found in 72 out of the 626 patients,including 64(10.4% ) in volvulus group and 8(88.9% ) in non-volvulus group.Mesenteric vessel whirl sign was complicated by intestinal canal whirl sign in 8 volvulus patients,complicated by superior mesenteric artery stricture in 6 volvulus patients.Mesenteric vessel whirl sign complicated by intestinal canal whirl sign was observed in only 2 non-volvulus patients with no superior mesenteric artery stricture.A difference in rotation angle and the start and end points of rotating vessels was found between the two groups(P

The new generation cyclooxygenase (COX-2) inhibitor could reduce the gastrointestinal side effect of NSAID drugs, but eventually increase the cardiovascular risk, because its selective inhibition of COX-2 induces the imbalance between PGI2 and TXA2 and the reduction of vasodilatory NO. Under pathological conditions, active oxygen species (O2-*2, etc) were used to induce endo- thelial dysfunction, activate NF-κB to induce expressions of pro-inflammatory cytokines IL-1β and TNF-α, increase ET-1, TXA2 with vasoconstrictor effect, reduce PGI2 and NO with vasodilatory effect, generate further oxidative damage together with NO, and reduce the bioavailability of NO. NO-NSAIDs and NO-Coxibs drugs raised the level of NO by introducing NO-donor (ONO2). NSAIDs drugs enhanced the anti-inflammatory activity of COX-2 and reduced gastrointestinal side effects by inhibiting selectively COX-2. If antioxidant structures with active ingredients of traditional Chinese medicines were introduced to improve the antioxidant activity of NSAIDs, they could scavenge the active oxygen species to protect the normal function of vascular endothelia and enhance the bioavailability of NO, which is conducive to enhance the cardiovascular safety of cyclooxygenase (COX-2) inhibitor.
Anti-Inflammatory Agents ; therapeutic use ; Biomarkers, Pharmacological ; Cardiovascular Diseases ; drug therapy ; enzymology ; immunology ; Cyclooxygenase 2 ; immunology ; Cyclooxygenase 2 Inhibitors ; adverse effects ; therapeutic use ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; NF-kappa B ; immunology ; Reactive Oxygen Species ; immunology ; Tumor Necrosis Factor-alpha ; immunology

The internal audit is important for the management system of laboratory .The article stated how to effectively implement internal audit in drug testing laboratories in terms of the planning , checklist, pattern, problem observation , CAPA of non-compliance and application of results in internal audit .

· AIM: To summarize the clinical features of Chinese primary congenital glaucoma and to investigate the discrepancies of the clinical features between the Chinese and Indian patients.congenital glaucoma patients were reviewed. The clinical features were summarized as several quantifiable clinical parameters and the severity of the disease was evaluated. Both the quantified clinical features and severity were statistically compared with those of the Indian patients, which were cited from the previous published articles.included in the study. In Chinese patients, sex ratio (male to female )was about 2:1, family history was presented in 3 patients (7.5%) and consanguinity was found in one patient (2.5%). The main symptoms and signs observed in Chinese patients spanned a wide spectrum of manifestations. The most frequent signs noted on the initial examination were enlarged eyeball (42.5%) and decreased visual acuity (35.0%). Compared with Indian patients, Chinese patients had a later onset, a delayed diagnosis, more severe corneal changes and more severe optic nerve damages (P＜0.01). The combined tabeculectomy and trabeculotomy operation was preferred by both Chinese and Indian doctors whereas a higher proportion of Indian patients received the combined operation (P＜0.01). The proportions of the severity grade were different between Chinese and Indian patients. Most Chinese patients were in the severe grade while most Indian patients were in the very severe grade (P＜0.01).patients were sporadic and non-consanguineous.Compared with Indian patients, Chinese patients had a relative later onset, a delayed diagnosis and treatment.More attempts are needed in Chinese PCG prevention and treatment.