Objective To summarize nursing points in the synchronous and sequential chemotherapy composed of combination medications to prevent adverse reactions of choriocarcinoma treatment.Methods 65 patients with choriocarcinoma who had received synchronous sequential chemotherapy were given nursing and physiological nursing concerning hematopoietic dysfunction,gastrointestinal reaction as well as liver and kidney dysfunction.Results Out of the 65 patients who had received synchronous sequential chemotherapy,45 were cured and 9 had clinical improvements,with total effective rate of 83.1％ and 3-4 medication courses on average.After the first treatment course,11 patients had hematopoietic dysfunction,5 had decreased food appetite,nausea,vomiting and oral cavity ulcer of different degrees,2 had kidney dysfunction,3 had alopecia and 5 had pigmentation where they received intravenous injection.But all adverse reactions disappeared after symptomatic treatment.Conclusions Synchronous sequential chemotherapy as well as careful nursing is very important to cure adverse reactions in choriocarcinoma patients with chemotherapy.