1.Transmission and prevalence patterns of C4a evolutionary lineage of human enterovirus 71 circulating in mainland China, 2008-2010.
Jing SHI ; Yan ZHANG ; Jian-Hui ZHOU ; Zhen ZHU ; Nai-Ying MAO ; Song-Tao XU ; Ai-Li CUI ; Xiao-Juan TAN ; Shuang-Li ZHU ; Yong ZHANG ; Dong-Mei YAN ; Xiao-Hui KONGG ; Wen-Bo XU
Chinese Journal of Experimental and Clinical Virology 2012;26(6):425-428
OBJECTIVETo understand the evolutionary relationship between the C4a evolutionary lineage of human enterovirus 71 (HEV71) strains circulating in mainland of China during 2008-2010 and 2008 Fuyang strains and study the prevalence and transmission patterns of 2008 Fuyang strains.
METHODSDownload all the complete VP1 ( > or = 891 bp) or approximate complete VP1 (> or = 876 bp) gene nucleotide sequences from GenBank of HEV71 strains circulating in Mainland of China during 2008-2010. And analyze the phylogenetic relationship between Fuyang strains and other provinces' strains using the MEGA software, version 5.0.
RESULTSAll of the HEV71 isolates circulating in Mainland of China during 2008-2010 were clustered into evolutionary lineage C4a except for eight strains grouped in the genotype A and one isolate belongs to evolutionary lineage C4b; the homology analysis showed there were 96.5%-100% identity between C4a viruses circulating in mainland China during 2008-2010 and 2008 Fuyang strains, and they were evolved from C4b viruses of 1998. The transmission chains of Fuyang strains were mainly transmitted in Guangdong, Jiangsu, Shanghai, Hunan, Shandong provinces.
CONCLUSIONThe predominant viruses circulating in Mainland of China during 2008-2010 were evolutionary lineage C4a of human Enterovirus 71; Fuyang transmission chains mainly distributed in southern of China and the Central China around Anhui provinces.
China ; epidemiology ; Disease Outbreaks ; Enterovirus A, Human ; classification ; genetics ; isolation & purification ; Enterovirus Infections ; epidemiology ; transmission ; virology ; Evolution, Molecular ; Female ; Humans ; Male ; Molecular Sequence Data ; Phylogeny ; Viral Proteins ; genetics
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