1. Regulation mechanism of unfolded protein response: Progress and clinical prospect
Academic Journal of Second Military Medical University 2010;28(3):325-328
Unfolded protein response(UPR) is a protective response in cell endoplasmic reticulum (ER) under stress condition. Three ER transmembrane proteins, IRE1, PERK, and ATF6, coordinately regulate the UPR function in mammalian cells through their signaling pathways. In addition, some proteins and transcription factors during the UPR can provide negative and positive feedback loops to maintain the normal function of ER. UPR can trigger cell death or apoptosis and eventually cause related diseases if the ER stress persists. Several key mediators of UPR are candidates for therapeutic targets in many studies. Up to now progress has been made in the area, which provides new ideas for clinical practice and holds a great potential for future application.
2.Research of memory of closed head injured patients during later recovering period
Chinese Journal of Rehabilitation Theory and Practice 2002;8(10):598-599
ObjectiveTo study memory impairment of closed head injured(CHI) patients during later recovering period. MethodsMemory function was examined in 20 CHI patients and 20 matched healthy controls by Clinical Memory Scale(CMS). ResultsThe scores of 5 sub tests and MQ of CHI group were significant lower than that of control group, the rate of MQ ≤ 79 in CHI patients was significant higher than in controls. Conclusion There are severe memory impairment in CHI patients during later period, the impairment of recall is more serious than that of recognition.
3.Discussion on internationalization of geriatric medical education
Hua MENG ; Xiao-ming WANG ; Hua ZHANG ; Jun GUO
Chinese Journal of Medical Education Research 2011;10(6):657-658
Geriatrics develops relatively late in medical education, but geriatric medical education is rapidly rising for aggravation of the aging of population.And geriatric medical education is desired of the properties medical sciences, and is also the need of the development itself. Therefore, geriatric medical education should be internationalized, to eventually form distinctive education.
4.Resveratrol inhibits high glucose-induced hypertrophy in myocardial cell line H9C2
Xiao WEI ; Jianming LEI ; Jingwen GUO ; Hua XIAO
Basic & Clinical Medicine 2017;37(3):320-324
Objective To investigate the effect of resveratrol on high glucose-induced oxidative stress and cardiomyo-cyte hypertrophy and possible mechanism .Methods H9C2 cardiomyocytes were divided into normal glucose group , high glucose group , resveratrol group and resveratrol +DAPT group respectively .The cell surface was measured by rhodamine-labeled phalloidin .Reactive oxygen species generation was measured using DCFH-DA.The contents of SOD and MDA were evaluated by colorimetry .The mRNA and protein levels of Notch 1, Hes1, ANP and BNP were evaluated by RT-qPCR and western blot .Results High glucose exposure significantly increased cell surface area ( P<0.01) and enhanced ROS and MDA generation ( P <0.01 ) with concomitant decrease of SOD activity ( P <0.01).It also decreased the mRNA and protein expressions of Notch 1 and Hes1(P<0.05), and increased the ex-pression levels of ANP and BNP ( P<0.05 ) .Resveratrol treatment inhibited cell surface expanding ( P<0.01 ) and decreased ROS and MDA generation (P<0.01) with concomitant enhance SOD activity (P<0.01), as well as in-creased the expression level of Notch 1 and Hes1 ( P<0.05 ) , and decreased the expression of ANP and BNP ( P<0.05).Conclusions Resveratrol may inhibit high glucose induced H9C2 cardiomyocytes hypertrophy by improving oxidative stress and activating Notch 1/Hes1 signaling pathway .
5.Airway management in acute cyanide poisoning.
Min-xiao LIU ; Guo-hua ZHOU ; Yi-hong WANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2010;28(2):152-153
Adult
;
Aged
;
Airway Management
;
Cyanides
;
poisoning
;
Female
;
Humans
;
Male
;
Middle Aged
;
Poisoning
;
nursing
;
Young Adult
7.Application of internal fixation combined with external fixator for unstable pelvic fracture.
Jin-hua GAO ; Wei HU ; Xiao-shan GUO
China Journal of Orthopaedics and Traumatology 2015;28(8):753-756
OBJECTIVETo invesitigate the clinical effects of percutaneous closed reduction and cannulated screw internal fixation combined with external fixation in the treatment of unstable pelvic fractures.
METHODSFrom April 2006 to May 2009,29 patients with pelvic fractures of rotatory instability were treated with closed reduction and screw internal fixation combined with external fixation. There were 19 males and 10 females with an average age of 31 years old (ranged from 19 to 53 years). Based on the Tile classification,17 cases were type CI and 12 case were type C2. Tornetta standard and Majeed score were used to evaluated the clinical effect after operation.
RESULTSAll patients were followed up from 10 to 24 months with an average of 16 months. There were no nerve injuries and other organ injuries, only one case of infection was found and it was cured with wound dressing. Time of fracture union was from 14 to 18 weeks with the mean of 16.2 weeks. No loosening, slippage or breakage of the screw were found. According to the Tornetta standards,14 cases obtained excellent results, 10 good, 4 fair and 1 poor. The Majeed score was 87.2 ± 11.3, 16 cases got excellent results, 9 good and 4 fair.
CONCLUSIONClosed reduction and screw internal fixation combined with external fixation is an effective way to treat unstable pelvic fractures with Tile type C1 and Tile type C2.
Adolescent ; Adult ; Child ; External Fixators ; Female ; Fracture Fixation, Internal ; methods ; Fractures, Bone ; surgery ; Humans ; Male ; Middle Aged ; Pelvic Bones ; injuries ; surgery
8.Nursing care of massive whole lung lavage in the treatment of pneumoconiosis.
Yu-Hua CHEN ; Xiao-Qing ZHENG ; Guo-Wu HONG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(8):616-617
Adult
;
Bronchoalveolar Lavage
;
nursing
;
Female
;
Humans
;
Male
;
Middle Aged
;
Pneumoconiosis
;
nursing
;
therapy
;
Retrospective Studies
9.Significance of Fas, FasL and FADD expression in squamous cell carcinoma of larynx
Haili SUN ; Hua GUO ; Yuhe LIU ; Ting LI ; Shuifang XIAO
Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(07):-
OBJECTIVE To investigate the expression and significance of Fas, FasL and FADD in laryngeal carcinoma. METHODS Immunohistochemical method was used to examine the expression of Fas, FasL and FADD in laryngeal carcinoma specimen and adjacent normal tissues. RESULTS The positive rates of Fas and FADD in laryngeal carcinoma tissue were significantly lower than that in adjacent normal tissue, while FasL in laryngeal carcinoma tissue was higher than that in adjacent normal tissue(P
10.The analysis of epidemiological and clinical characteristics of 112 cases patients with adult-measles
Xiao-Hua CHEN ; Jie XU ; Guo-Qing ZANG ;
Chinese Journal of Infectious Diseases 2001;0(03):-
Objective To analyze the clinical data of 112 patients with adult-measles in the Af- filiated Shanghai Sixth People's Hospital and Third People's Hospital of Shanghai Jiaotong University from January to June in 2005,and to evaluate the epidemiologieal and clinical characteristics of adult- measles.Methods To retrospectively analyze the clinical data of 112 patients with adult-measles. Results Totally,112 measles patients were involved in this study,with male 63 and female 49 re- spectively.The gender rate was 1.3:1,average age about 32 years and the proportion of non-resi- dents was 40.18%.The peak of the incidence of disease emerged in April and May,and the positive rate of measle virus IgM antibody in serum was 96.43%.There were 97 patients(86.61%)who had the fever that beyond 39℃and 36 patients(32.14%)who had measle caused viral hepatitis.Conclu- sions There is a trend that the ages of patients that suffered from measle were postponed and the in cidences of disease are increased year by year,which maybe related to the nonstandard inoculation of measle vaccine,or the decrease of IgM antibody levels and so on.Meanwhile,serious toxemie symp- toms and liver damage can be observed.