1.The relevant factors and strategies related efficacy with standard of care in chronic hepatitis C treatment naive patients.
Chinese Journal of Hepatology 2013;21(6):406-407
Antiviral Agents
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administration & dosage
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therapeutic use
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DNA, Viral
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blood
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Hepacivirus
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genetics
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Hepatitis C, Chronic
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drug therapy
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virology
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Humans
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Interferon-alpha
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administration & dosage
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therapeutic use
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Ribavirin
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administration & dosage
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therapeutic use
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Standard of Care
3.Mechanism of hepatitis B virus infection of trophoblast cells and hepatitis B virus intrauterine infection
Han BAI ; Yang DING ; Lin ZHANG ; Li MA ; Gui-Zhen ZHAO ; Xiao-Guang DOU ;
Chinese Journal of Infectious Diseases 2007;0(11):-
1.0?10~7 copies/mL. The HBsAg IHC staining positive cells could be observed in 6 placental tissues and 3 fetus' liver tissues,and HBcAg was also positive in 1 case of fetus' liver tissue.After co-incubating the tropho- blastic cells and HBV DNA positive serum in vitro,HBsAg expression and HBV DNA could be detected.Apoptosis of HBV-infected trophoblastic cells increased,which was demonstrated by in vivo and in vitro experiments and the apoptosis of placental cells was correlated with the cord blood HBV DNA level.The results of in vitro experiments showed that the apoptosis of trophoblastic cells increased with the elongation of infection time.After 6 months,1 of 12 newborns was positive for HBsAg,HBeAg and anti-HBc,6 was positive for anti-HBs.Conclusions The mechanism of HBV intra-uterine infection may be that HBV breaches the placental barrier and infects the fetus.The localization and replication of HBV in fetal tissues and organs are probably the important factors of chronic HBV infections in neonates.The apoptosis of trophoblastic cells may be the protective mecha- nism for the placental barrier to block the HBV intra-uterine transmission.
4. Clinical difficulties and hotspots of liver injury caused by non-hepatitis virus
Chinese Journal of Practical Internal Medicine 2019;39(06):487-488
There are many viruses causing liver injury in clinic, including hepatophilic and non-hepatophilic viruses. With the extensive vaccination of hepatitis B vaccine and strict management of blood products in newborns, patients with chronic hepatitis B and C will gradually decrease, while liver damage caused by non-hepatitis virus will gradually increase, which should be paid much attention to highly valued by clinicians.
5.Comparison of prognosis in children with acute viral myocarditis induced ventricular premature beats originating from different positions and the clinical value of mgocardial perfusion ECT.
Xiao-Guang CHEN ; Song FENG ; Wei GE ; Jin-Dou AN
Chinese Journal of Contemporary Pediatrics 2013;15(4):281-284
OBJECTIVETo study the difference in prognosis for children with acute viral myocarditis induced ventricular premature beats (VPB) originating from different positions, and to study the role of 99Mtc-MIBI myocardial perfusion ECT in the prognostic evaluation of VPB.
METHODSThe clinical data of 83 children with viral myocarditis induced VPB were retrospectively studied. They were divided into four groups according to the original site of VPB, as shown by the ECG: right ventricular (RV) outflow tract, RV anterior wall and apex, left ventricular (LV) outflow tract, LV anterior wall and apex. All patients were treated with anti-viral drugs and myocardial nutritional medicine. Short-term and long term outcomes in the four groups were compared. The relationship between the results of 99Mtc-MIBI myocardial perfusion ECT and prognosis in 40 patients was observed.
RESULTSThere were no significant differences in short-term and long-term effective rates among the four groups (P>0.05). There were no differences in the ECT positive rates between the patients with VPB originating from RV and those with VPB originating from LV (P>0.05). The treatment effective rates of ECT-positive patients were higher than the treatment effective rates of ECT-negative ones (P<0.05).
CONCLUSIONSThe short-term and long-term prognosis of children with VPB originating from different positions are not significantly different. In children with viral myocarditis induced VPB, positive ECT results suggest a better prognosis.
Acute Disease ; Humans ; Myocardial Perfusion Imaging ; methods ; Myocarditis ; complications ; Prognosis ; Retrospective Studies ; Technetium Tc 99m Sestamibi ; Ventricular Premature Complexes ; diagnostic imaging ; etiology ; Virus Diseases ; complications
6.Nucleos(t)ides analog block HBV mother-to-child transmission in pregnancy HBV carriers-agreement and challenges.
Dou XIAO-GUANG ; Ding YANG ; Sheng QIU-JU
Chinese Journal of Hepatology 2012;20(2):89-92
Antiviral Agents
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administration & dosage
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therapeutic use
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Female
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Hepatitis B
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transmission
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Hepatitis B virus
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Humans
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Infant, Newborn
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Infectious Disease Transmission, Vertical
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prevention & control
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Nucleotides
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administration & dosage
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therapeutic use
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Pregnancy
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Pregnancy Complications, Infectious
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prevention & control
8.Difficult-to-treat patient with chronic hepatitis C: a challenge in clinical practice.
Chinese Journal of Hepatology 2009;17(7):486-487
Antiviral Agents
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administration & dosage
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therapeutic use
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Drug Therapy, Combination
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Genotype
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Hepatitis C, Chronic
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blood
;
drug therapy
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pathology
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Humans
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Interferon-alpha
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administration & dosage
;
therapeutic use
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Polyethylene Glycols
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administration & dosage
;
therapeutic use
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RNA, Viral
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blood
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Ribavirin
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administration & dosage
;
therapeutic use
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Viral Load