Objective To explore the correlation between the need for cognitive closure and the way of coping with the disease in patients with hepatitis B cirrhosis. Methods 217 patients with hepatitis B cirrhosis were questionnaired by the Need for Cognitive Closure Scale and the Medical Coping Style Questionnaire (Chinese version). Results The total score of need for cognitive closure in separation and conversion disorder patients was (217.65 ± 31.23) points. The scores of face, yield and avoidance in the coping style were respectively (18.87±2.49) points,(13.21±1.53) points and (17.63±2.27) points. The score of face was significantly negatively correlated with the total score and all dimension scores of the need for cognitive closure(r=-0.421,-0.387,-0.405, P<0.05);the scores of yield and avoidance were positively correlated with the total score and all dimension scores of the need for cognitive closure (r=0.343-0.432, P<0.05). There were significant difference of the way of coping with the disease in the patients with different family income, payment method, course of disease (t=-3.080-3.490, P<0.05). Multiple regression analysis showed need for cognitive closure was influencing factor of way of coping with the disease in patients with hepatitis B cirrhosis. Conclusions The level of need for cognitive closure is in the high level in patients with hepatitis B cirrhosis, and influencing the way of coping with the disease.

A kind of simple portable electronic pulsometer based on piezoelectric sensor is designed, which constituted with single-chip microcomputer AT89S51. The piezoelectric sensor is used to transform pulse beating into electrical signal. Because the signal is very weak, the regular pulse profile is only obtained after enlargement and reshaping. Three-operation-amplifier circuit is used to magnify the weak signal from sensor, and the one-order low-pass filter is used to reshape the signal to get rid of miscellaneous signals. After timing and counting by the single-chip microcomputer, the pulse number is directly shown on light-emitting diode tubes through decoding circuit. The norm time generation circuit, a single steady trigger consisted of 555 integrated circuit chip mainly, set the standard time. The single-chip microcomputer AT89S51 circuit control the enlargement and reshaping of the original signal and time trigger. This portable electronic pulsometer has many advantages, such as simple structure, steady and reliable working, direct number display, low error (

A kind of personal computer-based monitoring system with piezoelectric sensor for pulse signal is developed,which constitutes with single-chip microcomputer AT89S52 and personal computer. The integrated polyvinylidene difluoride piezoelectric pulse sensor is used to pick up the pulse signals of examined person and transfer to electric signal under processing. The weak signal from the sensor is enlarged through three-operation-amplifier circuit. The magnified pulse signal is converted digital pulse signal through ADC0809 chip and the pulse number can directly show on LED tubes through the coding circuit. At the same time the digitalized pulse signal is delivered to personal computer through serial communication interface of single-chip microcomputer AT89S52 and personal computer under RS-232-C serial communication interface protocol. The pulse signal is then shown,recorded,saved and processed through computer software. The single-chip microcomputer AT89S52 circuit controls the collection and enlargement of the original signal and communicated with personal computer. When the single-chip microcomputer part is not connected with computer under serial communication interface,it becomes an improved portable electronic pulsometer and can be taken conveniently and show pulse number.

An universal serial bus (USB)-based high-speed real-time pulse signal detecting system is developed. The hardware and application software of the system is presented. The integrated polyvinylidene difluoride (PVDF) piezoelectric pulse sensor is used to pick-up the pulse signals of examined person and turn to the electric signal under processing. Because the signal is very weak, only after passing through the enlargement can the regular pulse profile be allowed to be obtained. The in-phase amplifier circuit is used to magnify the weak signal from the sensor. The magnified pulse signal is converted digital pulse signal through system-on-chip single-chip microcomputer C8051F130. The digitalized pulse signal is delivered to personal computer under USB interface protocol. The pulse signal is then shown, recorded, saved and processed through computer software. This inspecting system for pulse signal has many advantages, such as its structure is simple, it works steadily and reliably, its low cost, high application value and it can also realize rapid collection and storage of pulse signal.

Objective To investigate the application of pathogenic examination and biomarkers detection of cerebrospinal fluid in diagnosis of intracranial infection .Methods Pathogenic and biomarkers examination were performed in cerebrospinal fluid of 49 cases with intracranial infection (infection group) and 49 cases of craniocerebral trauma but without intracranial infection (control group) .Results Adenosine deaminase activity obviously increased in tuberculous meningitis cases ,glucose levels decreased in bac‐terial meningitis and cryptococcal meningitis cases ,protein and IgA content increased in bacterial meningitis cases ,IgG levels in‐creased in bacterial meningitis and tuberculous meningitis cases ,IgM levels increased in tuberculous meningitis cases (P<0 .05) . There were no significant differences of biomarkers levels between viral meningitis cases and control group (P>0 .05) .Conclusion Combined pathogenic detection and biomarker detection of cerebrospinal fluid could be helpful for the diagnosis and treatment of intracranial infection .

Tuo-Fawas one of three internal treatment rules in traditional Chinese medicine (TCM) surgery. It had been widely used in the treatment of superficial suppurative diseases, visceral suppurative diseases and other diseases. This article was aimed to clarify the action mechanism ofTuo-Fa for carrying forward better services in the clinic. This article reviewed and recapitulated related literatures on experimental researches ofTuo-Fa in recent years. It mainly showed the research status on anti-infection, anti-tumor and anti-gastric ulcer withTuo-Fa and its prescriptions. It summarized the existed shortcomings, which was that experimental researches on the action mechanism ofTuo-Fa was still on the initial stage with a few references and obviously lagged behind clinical applications. However, some achievements were also made. It had initially revealed the action mechanism ofTuo-Fa in treatment of pyogenic infection. It also had research on action mechanism of anti-tumor and anti-gastric ulcer treatment. It developed new field for the clinical practice. Finally, the research on action mechanism ofTuo-Fa and future prospects were expressed.

Objective To investigate the correlation between NT‐proBNP ,hs‐CRP level ,echocardiography and early avascu‐lar necrosis of coronary artery syndrome (ACS) ,coronary artery lesion degree .Methods 142 patients admitted in this hospital for chest pain from March 2013 to February 2014 were enrolled ,and all patients′history ,electrocardiogram (ECG) ,plasma levels of N‐terminal pro‐Brain Natriuretic Peptide (NT‐proBNP) ,hypersensitive C‐reative protein (hs‐CRP) and cTnT were recorded or tested within 24 hours ,while left ventricular ejection fraction (LVEF) and left ventricular end‐diastolic diameter (LVEDd) were recorded by echocardiography .According to the history and coronary angiography results conducted during hospitalization ,patients were di‐vided into acute ST segment elevation myocardial infarction (STEMI) group ,acute non‐ST segment elevation myocardial infarction (NSTEMI) group ,unstable angina pectoris (UA) group and control group (normal coronary angiography ,cTnT and ECG) .Pa‐tients with abnormal coronary angiography results were further divided into single vessel lesion group ,double vessel lesion group and triple vessel lesion group .The differences of plasma NT‐proBNP level ,hs‐CRP level and LVEF in each group ,and multivariate linear regression analysis were conducted to find out the independent risk factors for elevated plasma NT‐proBNP .Results 102 ACS patients and 40 normal patients were enrolled .Plasma levels of NT‐proBNP ,hs‐CRP and LVEF in NSTEMI group (n=30) and STEMI group (n=32) were significant different from UA group (n=40) and control group (n=40) respectively (P<0 .05) . The NT‐proBNP levels in control group and triple vessel lesion group (n=41) were respectively significant different from both sin‐gle vessel lesion group (n=30) and double vessel lesion group (n=31) (P<0 .05) .Multivariate linear regression analysis showed that ,plasma hs‐CRP level (P=0 .007) ,coronary artery lesion degree (P=0 .00) and history of diabetes (P=0 .006) were positive associated factors of NT‐proBNP level ,while LVEF was the negative associated factors of NT‐proBNP level(P=0 .036) .Conclusion Plasma NT‐proBNP level ,hs‐CRP level and LVEF are closely related to ACS ,and they might play an important role in determi‐ning the extent of early ischemic necrosis and clinical classification .Plasma NT‐proBNP level could be an important molecular mark‐er to reflect the degree of coronary artery lesion .

Objective Liver is a common site of metastasis of gastric cancer and hitherto there has been no uniform treatment for liver metastasis of gastric cancer. This study was to investigate the clinical characteristics and prognostic factors of liver metastasis of gastric cancer in order to provide some evidence for the improvement of the diagnosis and treatment of the disease. Methods We ret-rospectively analyzed the clinical characteristics and survival data of 143 patients with liver metastasis of gastric cancer treated in our hospital between March 2007 and September 2012. We investigated the independent risk factors affecting the prognosis of the disease u-sing the Cox Regression Model. Results Seventy-five ( 52. 4%) of the 143 patients survived for 12 months, 41 ( 28. 7%) for 24 months, and 18 (12.6%) for 36 months, with a median survival time of 14 months. Univariate analysis revealed statistically significant differences in the survival time among the patients with different histological grades of primary gastric cancer, time of liver metastasis, types of metastatic liver cancer, extra-liver metastasis, and treatment methods ( P<0.05) . Multivariate Cox regression analysis showed the histological grade of gastric cancer to be low-or non-differentiation ( HR=2.67, 95% CI:1.51-4.72) and the type of liver meta-static cancer to be H2 ( HR=1.89, 95% CI:1.08-3.29) or H3 ( HR=2.13, 95% CI:1.32-3.44) , which were independent risk fac-tors affecting the prognosis of liver metastasis of gastric cancer, while palliative chemotherapy ( HR=0.55, 95% CI:0.32-0.95) was an independent protective factor of its prognosis. Conclusion Patients with liver metastasis from gastric cancer usually have a poor prognosis, especially those with histologically low-grade gastric cancer or type-H2 or -H3 liver metastatic cancer. The prognosis of thepatients undergoing palliative chemotherapy may have a better prognosis than those receiving best supportive care. A comprehensive therapy should be recommended to patients with liver metastasis from gastric cancer.

Objective To summarize the experience in major vessels reconstruction after resection of retroperitoneal neoplasm invided major vessel. Methods Sixteen patients with retroperitoneal neoplarsm invading major vessels underwent resection of the tumor companying with the inviding major vessels, and the resected vessels were reconstructed.Of them, 13 artificial vessels were placed for the vascular reconstruction,and 3 underwent inferior vena cava partial resection and repair with or without PTFE patch;combined reconstruction of arteries and veins were performed on 6 patients,and combined resection and reconstruction of vessels and other invaded organs were performed on 3 patients. Results There was no operative mortality in this series. Fourteen patients were followed up for 3-71 months( averaged 30 months) .Five patients died,in which 3 patients died within 12 months, 1died at 64 months and 1died at 71 months after surgery,respectively.There were no obstruction of the reconstructed vessels during follow up. Conclusions Combined resection of retroperitoneal neoplasm with invided major vessel and vascular reconstruction is a safe, effective operation for retroperitoneal neoplasm companying with inviding major vessel.

p16 tumor suppressor gene plays an important role in early diagnosis for lung cancer. The occurrence of lung cancer is closed associated with p16 gene aberrant methylation in promotor, seconed exon homozygous deletion, gene point mutation , lose of protein and mRNA expression. Also p16 is related to gene therapy and drug target therapy. This review will summarize the relationship between p16 and lung cancer.