Objective:To investigate the effect of X-irradiation on Adhesion molecules and their related biological characteristics of Human Lung.Methods:A549 cells were irradiated with varying doses of X-rays.MTT assay was employed to evaluate the effects of X-irradiation on the proliferative inhibition of A549 cells.The immunocytochemical method was employed to analyze the protein expression levels of E-cadherin and ?-catenin.The transwell chambers were employed to evaluate the invasion of A549 cells.Results:X-irradiation could inhibit the proliferation of A549 cells in a dose-dependent manner.The protein expression of E-cadherin and ?-catenin in A549 were higher than that in control group(P

Cerebral white matter damage is the most common form of brain injury in premature infants,which is the main cause of neurological and mental injury and cerebral palsy.Imaging examination plays an important role in the diagnosis and follow-up of white matter damage.Because of the safe and accurate characteristics,nuclear magnetic resonance has become the most common imagine form.Different from the traditional nuclear magnetic resonance technique,diffusion tensor imaging (DTI) can get quantitative analysis of cerebral white matter fiber bundle in vivo.This technology has become a powerful tool for the evaluation of white matter damage.The article summarizes the application of DTI in the neurodevelopmental evaluation of cerebral white matter damage in premature infants.

OBJECTIVE: To optimize the formulation of ketamine hydrochloride for intranasal administration that was of effective anesthetic effect.METHODS: Using ketamine hydrochloride injection as basic preparation,various nasal absorption enhancer or viscosity modifiers(0.5%,1% and 2% azone,EDTA,carbomer,2-hydroxypropyl-?-cyclodextrin,carboxymethyl cellulose) were added to make different nasal drops.After intranasal administration,the anesthetic effect was evaluated to find the optimum formulation.The behavior of anesthetic induction period and anesthetic index were used to evaluate the anesthetic effect.RESULTS: The perfect anesthetic effect was achieved when the formulation was prepared by adding 1% azone in ketamine hydrochloride injection(at a dose of 10 mg?kg-1).The anesthetic time was long.The muscle relaxing time,eyelid reflecting disappearing time,pain disappearing time and righting reflecting disappearing time were(21.4?7.1) min,(11.4?4.6) min,(15.6?5.7) min and(12.0?4.8) min,respectively.CONCLUSIONS: Optimal formulation of ketamine hydrochloride for intranasal administration was obtained when 1% azone was added as an absorption enhancer.

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Objective:To explore the application effect of 3D printing teaching model on spinal surgery teaching.Methods:A total of 50 eight-year clinical medical students of Batch 2015 were selected and randomly divided into two groups. Traditional teaching mode was used in the control group and 3D printing teaching model was used in the experimental group. The performance of graduation from the department, teaching experience indicators and teaching satisfaction were compared between the two groups. SPSS 22.0 was used for t test. Results:The performance of the experimental group was higher than that of the control group ( P < 0.05). The scores of teaching experience indicators in the experimental group were all higher than those in the control group ( P<0.05). The satisfaction rate of the experimental group was higher than that of the control group ( P < 0.05). Conclusion:3D printing teaching model can significantly improve students' theoretical knowledge assessment and surgical design evaluation, and improve the teaching effect and students' satisfaction.

Acrylonitrile ; toxicity ; Animals ; Male ; Mice ; Mice, Inbred Strains ; Testis ; drug effects ; pathology

Increases in diagnostic frequency of breast ductal carcinoma in situ(DCIS) have followed the introduction of mammographic screening in past years.It is very important to distinguish the clinical syndrome of DCIS.The management of surgery for DCIS includes mastectomy,lumpectomy plus radiotherapy and lumpectomy alone; axillary lymph node dissection(ALND) in DCIS has not been recommended and sentinel lymph node biopsy(SLNB) is still controversial; adjuvant radiotherapy for ipsilateral whole breast and endocrine treatment can reduce local recurrence,prevent second primary breast tumor,preclude regional and distant metastasis.But whatever we take towards the DCIS above,there is little disturbance to DCIS' s inherent prognosis.Doctors must pay enough attention to this point.

Epilepsy, Absence ; Humans

Titanium & titanium alloy are popular in dentistry as dental material because of their good mechanical properties and extremely good biocompatibility. The bonding strength between the titanium and the resin agent is the decisive factor in evaluating the success of resin-bonded restoration. Appropriate surface treatment on the titanium is an effective way to reinforce the bending strength. The purpose of this review is to summarise the relevant studies and introduce some latest findings.

Objective To observe the attachment,shape,function and activity of human umbilical cord mesenchymal stem cells cultured on silk fibroin porous scaffolds in vitro,and to provide experimental foundation for the choice of scaffold in the study of adipocyte tissue engineering.Methods These silk fibroin porous scaffolds were subsequently seeded with hUCMSCs and cultured in vitro.The growth and function of hUCMSCs were observed and measured with fluorescence inverted microscopy,scanning electronic microscopy and MTT methed. Results hUCMSCs were fixed on silk fibroin porous scaffolds 1 or 2 days later,and multiplicative growth was observed on the 5th to 7th day.After about 10 days,the microholes of the scaffolds were overlayed by hUCMSCs.Scanning electronic microscopy and fluorescence inverted microscopy showed that cells adhered to scafold well and there was a lot of extra cellular matrix surrounding cells. Conclusion Silk fibroin porous scaffolds are ideal for attachment,growth,function maintenance and activity of hUCMSCs.and the scaffolds can be used as natural scaffolds for hUCMSCs in 3D culture.