The thiobarbituric acid (TBA) assay was used to determine non-enzymatic glycosylation of hair and fingernail keratin in non-diabetics and diabetics. Some measuring conditions including the amount of sample, the duration of hydrolysis, etc were described. The concentration of glycosylated hair protein (GHP) and glycosylated nail protein (GNP) in diabetics were both significantly higher than that in non-diabetics. GHP and GNP might be used as a monitor marker in retrospecfive assessment of chronic hyperglycemia.

Objective:To approach the effective way of early diagnosis and therapy of cervical gestation.Methods:A retrospective analysis was conducted by analyzing the clinical presentations and auxiliary examinations of 23 cases of cervical pregnancy.Results:19 cases were cured by conservative treatment;3 cases were cured by hysterectomy.Conclusion:Cervical pregnancy is related to curettage and cesarean;ultrasound can provide valuable information for diagnosis and therapy;conservative treatment,including medical treatment,conservative operation and interventional therapy,are effective approaches which can reserve menstruation and reproductive ability.

Objective:To investigate the expression and significance of hcpatocyte growth factor (HGF) and c-Met,receptor (c-Met) in endometrial carcimoma.Methods:Using S-P immunohistochemistry method,the expression of HGF and c-Met in the specimens of 52 cases with endometrial catcmoma and 16 cases with normal endometrium was examined.Then the correlation was analyzed between the two factors and the stage and differentiation of EC.Results:The expressions of HGF and c-Met in endometrial carcinoma were significantly higher than in normal endometrium.The expression of c-Met was closely associated with the stage and differentiation of endometrial carcinoma.Conclusion:Overexpression of HGF and c-Met facilitates the malignant progress of endometrium,c-Met is associated with the prognosis of EC.

Objective:To investigate the expression of beta-catenin,protein APC and its implication in ovarian epithelial tumor.Methods:Immunohistochemical staining with ABC method was conducted to determine the expression of beta-catenin and protein APC in 48 cases of ovarian epithelial tumors.Results:The rate of beta-catenin in ovarian malignant epithelial tumor was higher than that in benign epithelial tumor,and the rate in borderline epithelial tumor was higher than that in benign epithelial tumor too.There was significant difference between them.The prevalence of protein APC positive in ovarian benign epithelial tumor was significantly greater than that in ovarian malignant epithelial tumor.A significant negative correlation was found between beta-catenin and protein APC in ovarian epithelial tumor.Conclusion:The results suggest that beta-catenin and APC protein have important effects on pathogenesis and development of ovarian epithelial tumors.

Objective:To investigate the relationship between placenta thrombosis and bad outcomes of late pregnancy.Methods:6 cases of placenta thrombosis collected in the hospital where the author work from 2000～2006 were analysed retrospectively.Results:Two cases was complicated by venous thromboembolism.Four cases was with previous spontaneous abortion.One case was with primary infertility.One multigravida had history of sever preeclampsia.The onset of disease were between 32～37 weeks gestational age.Five cases were complicated with hypertensive disorders.All cases were complicated by fetal distress.Antiphosphlipid antibody was found in two cases.Conclusion:Placenta thrombosis would result in fetal distress.Anticoagulation is recommended for higy risk women for thromboembolism

In order to improve obstetrics and gynecological teaching effect,the teacher should be of great responsibility,apply scientific method,drive Students' go-aheadism and make the best use of clinical resource during clinical demonstration.

Object: To investigate the expression of beta-catenin,protein APC,c-myc and cyclin D1 in Ovarian epithelial tumor and to discuss its significance.Methods: Expression of beta-catenin,protein APC,c-myc and cyclin D1 were examined by ABC immunohistochemistry in 48 cases of Ovarian epithelial tumor.Results: The rate of abnormal expression of beta-catenin in ovarian malignant epithelial tumor was higher than that in benign epithelial tumor(P

Hemangioma ; Humans ; Vascular Malformations

Objective To investigate the changes of CA125 level with intra-abdominal tumor(epithelial ovarian cancer ,fallopian tube cancer and peritoneal cancer ) before and after chemotherapy serum and their effect on the prognosis of patients and their the clinical predictive value .Methods 174 cases(107 cases of epithelial ovarian cancer ,35 cases of fallopian tube cancer ,and 32 cases of peritoneal cancer) with peritoneal cancer patients were selected from January 2007 to January 2008 .The percentage decrease of ser-um CA125 were calculated after 3 courses of chemotherapy and CA125 decreased level of sensitivity with chemotherapy were ana-lyzed .The different levels of CA125 of median survival time and median survival time were compared .Results After chemothera-py ,CA125 decreased ≥ 75% in 42 cases ,decreased from 51% to 75% in 62 cases ,decreased from 25% to 50% in 32 cases ,and de-creased less than 25% in 38 cases .In CA125 decreased ≥ 75% group ,the chemotherapy effects was better than the other groups (P<0 .05) .Univariate analysis showed that the decrease proportion of CA 125 was positively correlated with chemotherapy effect (r=0 .396 ,P=0 .000) .Using the Kaplan-Meier method ,the patient's survival rate and median survival time were caculated and it showed that the 5 years survival and median survival time were significantly better in group CA 125 decline ≥ 75% than the other groups(P<0 .05) .Univariate analysis shows that the CA125 decline proportion of patients and long term efficacy was positively correlated(r=0 .412 ,P=0 .000) .The COX risk model analysis showed that FIGO stage ,CA125 level and the effect of chemothera-py were independent prognostic risk factors .Conclusion The level of CA125 is the independent risk factor of epithelial ovarian cancer ,fallopian tube cancer and peritoneal cancer prognosis .CA125 decline proportion could be used to know the effect of chemo-therapy and long term treatment ,and be the prognosis indicators for patients with intra abdominal tumor .

Since 2007,in order to comply with the hospital's strategic development and construction of the subjects,our hospital treat the research project management as the starting point,through the establishment of a sound project management and funding approaches; strengthen project process management,implement the total quality control; use of information technology tools to improve project management effectiveness.After several years of implementation,the number of our hospital's research projects above provincial and ministerial level has gradually increased,manyhigh level of SCI papers are emerging,and discipline construction has also been effectively carried out,all of which have promotedour research strength,the development of medical teaching and research.Therefore,we will continue to strengthen project management,and fully mobilize the initiative staff awareness of service,make full use of scientific information systems in future scientific research management to boost hospital disciplines.