A kind of simple portable electronic pulsometer based on piezoelectric sensor is designed, which constituted with single-chip microcomputer AT89S51. The piezoelectric sensor is used to transform pulse beating into electrical signal. Because the signal is very weak, the regular pulse profile is only obtained after enlargement and reshaping. Three-operation-amplifier circuit is used to magnify the weak signal from sensor, and the one-order low-pass filter is used to reshape the signal to get rid of miscellaneous signals. After timing and counting by the single-chip microcomputer, the pulse number is directly shown on light-emitting diode tubes through decoding circuit. The norm time generation circuit, a single steady trigger consisted of 555 integrated circuit chip mainly, set the standard time. The single-chip microcomputer AT89S51 circuit control the enlargement and reshaping of the original signal and time trigger. This portable electronic pulsometer has many advantages, such as simple structure, steady and reliable working, direct number display, low error (

A kind of personal computer-based monitoring system with piezoelectric sensor for pulse signal is developed,which constitutes with single-chip microcomputer AT89S52 and personal computer. The integrated polyvinylidene difluoride piezoelectric pulse sensor is used to pick up the pulse signals of examined person and transfer to electric signal under processing. The weak signal from the sensor is enlarged through three-operation-amplifier circuit. The magnified pulse signal is converted digital pulse signal through ADC0809 chip and the pulse number can directly show on LED tubes through the coding circuit. At the same time the digitalized pulse signal is delivered to personal computer through serial communication interface of single-chip microcomputer AT89S52 and personal computer under RS-232-C serial communication interface protocol. The pulse signal is then shown,recorded,saved and processed through computer software. The single-chip microcomputer AT89S52 circuit controls the collection and enlargement of the original signal and communicated with personal computer. When the single-chip microcomputer part is not connected with computer under serial communication interface,it becomes an improved portable electronic pulsometer and can be taken conveniently and show pulse number.

An universal serial bus (USB)-based high-speed real-time pulse signal detecting system is developed. The hardware and application software of the system is presented. The integrated polyvinylidene difluoride (PVDF) piezoelectric pulse sensor is used to pick-up the pulse signals of examined person and turn to the electric signal under processing. Because the signal is very weak, only after passing through the enlargement can the regular pulse profile be allowed to be obtained. The in-phase amplifier circuit is used to magnify the weak signal from the sensor. The magnified pulse signal is converted digital pulse signal through system-on-chip single-chip microcomputer C8051F130. The digitalized pulse signal is delivered to personal computer under USB interface protocol. The pulse signal is then shown, recorded, saved and processed through computer software. This inspecting system for pulse signal has many advantages, such as its structure is simple, it works steadily and reliably, its low cost, high application value and it can also realize rapid collection and storage of pulse signal.

Objective To explore the correlation between the need for cognitive closure and the way of coping with the disease in patients with hepatitis B cirrhosis. Methods 217 patients with hepatitis B cirrhosis were questionnaired by the Need for Cognitive Closure Scale and the Medical Coping Style Questionnaire (Chinese version). Results The total score of need for cognitive closure in separation and conversion disorder patients was (217.65 ± 31.23) points. The scores of face, yield and avoidance in the coping style were respectively (18.87±2.49) points,(13.21±1.53) points and (17.63±2.27) points. The score of face was significantly negatively correlated with the total score and all dimension scores of the need for cognitive closure(r=-0.421,-0.387,-0.405, P<0.05);the scores of yield and avoidance were positively correlated with the total score and all dimension scores of the need for cognitive closure (r=0.343-0.432, P<0.05). There were significant difference of the way of coping with the disease in the patients with different family income, payment method, course of disease (t=-3.080-3.490, P<0.05). Multiple regression analysis showed need for cognitive closure was influencing factor of way of coping with the disease in patients with hepatitis B cirrhosis. Conclusions The level of need for cognitive closure is in the high level in patients with hepatitis B cirrhosis, and influencing the way of coping with the disease.

Objective To observe the clinical efficacy and safety of nicergoline and aniracetam in treatment of mild and moderate cognitive dysfunction after cerebral infarction .Methods Infarction were enrolled after 70 cases of mild and moderate cognitive im-pairment patients were randomly divided into nicergoline treatment group (observation group) and aniracetam treatment group(con-trol group) ,all 35 cases .After 12 weeks of treatment were compared before and after treatment mini mental state examination (MMSE) ,activities of daily living scale(ADL) scores and transcranial Doppler(TCD) to improve the situation .Results After 12 weeks ,both groups after treatment compared with treatment MMSE score was significantly higher (P< 0 .05) ,and nicergoline group than aniracetam group(P< 0 .01);ADL score before treatment were significantly reduced (P< 0 .05) ,TCD improvement nicergoline group than aniracetam group (P<0 .01) .Conclusion Nicergoline mild and moderate cognitive dysfunction after cerebral in-farction have significant effects ,and better than aniracetam ,no significant adverse reactions occur for a wide range of clinical applications .

Tuo-Fawas one of three internal treatment rules in traditional Chinese medicine (TCM) surgery. It had been widely used in the treatment of superficial suppurative diseases, visceral suppurative diseases and other diseases. This article was aimed to clarify the action mechanism ofTuo-Fa for carrying forward better services in the clinic. This article reviewed and recapitulated related literatures on experimental researches ofTuo-Fa in recent years. It mainly showed the research status on anti-infection, anti-tumor and anti-gastric ulcer withTuo-Fa and its prescriptions. It summarized the existed shortcomings, which was that experimental researches on the action mechanism ofTuo-Fa was still on the initial stage with a few references and obviously lagged behind clinical applications. However, some achievements were also made. It had initially revealed the action mechanism ofTuo-Fa in treatment of pyogenic infection. It also had research on action mechanism of anti-tumor and anti-gastric ulcer treatment. It developed new field for the clinical practice. Finally, the research on action mechanism ofTuo-Fa and future prospects were expressed.

Objective To investigate the correlation between NT‐proBNP ,hs‐CRP level ,echocardiography and early avascu‐lar necrosis of coronary artery syndrome (ACS) ,coronary artery lesion degree .Methods 142 patients admitted in this hospital for chest pain from March 2013 to February 2014 were enrolled ,and all patients′history ,electrocardiogram (ECG) ,plasma levels of N‐terminal pro‐Brain Natriuretic Peptide (NT‐proBNP) ,hypersensitive C‐reative protein (hs‐CRP) and cTnT were recorded or tested within 24 hours ,while left ventricular ejection fraction (LVEF) and left ventricular end‐diastolic diameter (LVEDd) were recorded by echocardiography .According to the history and coronary angiography results conducted during hospitalization ,patients were di‐vided into acute ST segment elevation myocardial infarction (STEMI) group ,acute non‐ST segment elevation myocardial infarction (NSTEMI) group ,unstable angina pectoris (UA) group and control group (normal coronary angiography ,cTnT and ECG) .Pa‐tients with abnormal coronary angiography results were further divided into single vessel lesion group ,double vessel lesion group and triple vessel lesion group .The differences of plasma NT‐proBNP level ,hs‐CRP level and LVEF in each group ,and multivariate linear regression analysis were conducted to find out the independent risk factors for elevated plasma NT‐proBNP .Results 102 ACS patients and 40 normal patients were enrolled .Plasma levels of NT‐proBNP ,hs‐CRP and LVEF in NSTEMI group (n=30) and STEMI group (n=32) were significant different from UA group (n=40) and control group (n=40) respectively (P<0 .05) . The NT‐proBNP levels in control group and triple vessel lesion group (n=41) were respectively significant different from both sin‐gle vessel lesion group (n=30) and double vessel lesion group (n=31) (P<0 .05) .Multivariate linear regression analysis showed that ,plasma hs‐CRP level (P=0 .007) ,coronary artery lesion degree (P=0 .00) and history of diabetes (P=0 .006) were positive associated factors of NT‐proBNP level ,while LVEF was the negative associated factors of NT‐proBNP level(P=0 .036) .Conclusion Plasma NT‐proBNP level ,hs‐CRP level and LVEF are closely related to ACS ,and they might play an important role in determi‐ning the extent of early ischemic necrosis and clinical classification .Plasma NT‐proBNP level could be an important molecular mark‐er to reflect the degree of coronary artery lesion .

Objective To investigate the application of pathogenic examination and biomarkers detection of cerebrospinal fluid in diagnosis of intracranial infection .Methods Pathogenic and biomarkers examination were performed in cerebrospinal fluid of 49 cases with intracranial infection (infection group) and 49 cases of craniocerebral trauma but without intracranial infection (control group) .Results Adenosine deaminase activity obviously increased in tuberculous meningitis cases ,glucose levels decreased in bac‐terial meningitis and cryptococcal meningitis cases ,protein and IgA content increased in bacterial meningitis cases ,IgG levels in‐creased in bacterial meningitis and tuberculous meningitis cases ,IgM levels increased in tuberculous meningitis cases (P<0 .05) . There were no significant differences of biomarkers levels between viral meningitis cases and control group (P>0 .05) .Conclusion Combined pathogenic detection and biomarker detection of cerebrospinal fluid could be helpful for the diagnosis and treatment of intracranial infection .

Science of Meridians and Acupoints of the new version has been obviously improved in terms of bookbinding and printing quality and the concrete textbook content as compared with the textbook of the old version. However, some questions had been discovered during actual usage in the past semester. The writer makes the discussion from 4 aspects, named content arrangement, content statement, content correction and phonetic notation of rare words. The writer puts forward his own opinions on a part of acupoints essentially and points out some mistakes in the textbook.
Acupuncture Points ; Acupuncture Therapy ; Books ; Humans ; Meridians

p16 tumor suppressor gene plays an important role in early diagnosis for lung cancer. The occurrence of lung cancer is closed associated with p16 gene aberrant methylation in promotor, seconed exon homozygous deletion, gene point mutation , lose of protein and mRNA expression. Also p16 is related to gene therapy and drug target therapy. This review will summarize the relationship between p16 and lung cancer.