Objective To explore the antagonistic effect of Schistosoma japonicum soluble adult worm antigen (SWA)and solu-ble egg antigen (SEA)in the mice with type 1 diabetes.Methods The 24 successful modeling type 1 diabetes mice were randomly divided into three groups (A,B,C group,n=8).SWA and SEA of Schistosoma japonicum were prepared.Mice in A group were immunized by abdominal subcutaneous multi-point injection SWA.Mice in B group were immunized by abdominal subcutaneous multi-point injection SEA.And mice models of C group were immunized by PBS instead of antigen through abdominal subcutaneous injection.The mice got immunization once a week,a total of four times.4 weeks later,the mice were sacrificed,and serum speci-mens were collected for the determination of serum levels of IL-4 and IFN-γby double-antibody sandwich ELISA,while pancreas tissues were collected and the pathological changes were observed.Results The serum IL-4 level of B group [(23.87 ±4.85)pg/mL]was higher than C group [(4.39 ± 0.56 )pg/mL],with significant differences (P < 0.01 ),while the serum IFN-γ level [(271.85±26.04)pg/mL]was lower than C group [(362.79 ±32.50)pg/mL],also with significant differences (P <0.01).The serum IL-4 and IFN-γof A group were (5.09±0.37)pg/mL and (379.56±34.47)pg/mL,which had no difference with C group (P >0.05).The islet structure of mice in B group was not intact,however,the lymphocytic infiltration in B group was less than C group,and there was no lymphocytic infiltration in pancreatic islets in B group.Compared with C group,the pancreas of mice in A group did not have significant changes,lymphocytes infiltration was still visible in islets.The number of residual islet cells de-creased,and visible minority islet structure was destroyed.Conclusion SEA of Schistosoma japonicum has certain antagonism effect on type 1 diabetes in experimental mice.Its mechanism may be the reduction of Th1 response and the enhancement of Th2 response through increasing IL-4 level and decreasing IFN-γlevel.

The articles concerning intensive effect and progress of interventional therapy for hepatocellular carcinoma (HCC) recurrence were comprehensively reviewed. Along with unceasing abundance of all interventional methods (including transcatheter arterial chemoemblization (TACE),percutaneous dehydrated ethanol injection,radio frequency ablation,percutaneous microwave therapy,argon-helium cryoablation,high-intensity focused ultrasound and radionuclide interventional therapy,etc),combined interven-tional therapies mainly TACE were increasingly appreciated in postoperative HCC recurrence,but still have to be further standardized. With further emerging and maturing of new technologies,such as antiangiogenesis,gene therapy and targeted therapy on HCC metastatic and recurrence specific cycle; the effect of combined therapy will be further promoted. Interventional therapy will play an important role in the prevention and treatment of postoperative HCC recurrence in the foreseen furture.

Objective:To study the cognitive features of text anxiety. Methods: The cognitive features of text anxiety were explored by exploratory factor analysis and confirmatory factor analysis on the basis of interview,questionnaire surveying and criterion.Results:There were 6 cognitive factors leading to test anxiety: self-test, worrying, magnifying conclusion, resistance, preparing, self-efficacy.Conclusion: The 6 factors of cognition about text are related to text anxiety

The interventional therapy of chemoembolization is the first management of choice in treating unresectable hepatic carcinomas but with some side effects including liver function damage and bone marrow restraints which may affect the patients'life expectancy and living quality in the long run.The advancement of the combination of interventional treatment with Chinese drugs in managing liver carcinomas is a special presentation by the auther for further recommondation.

Basic research in interventional radiology,including transcatheter artery perfusion especially,is progressing slowly due to lack of proper method.Microdialysis technique,a kind of accurate sampling technique in vivo,may help to solve the problem.Just as its name implies,microdialysis means tiny dialysis with advantages of authenticity,exactness and less error.Furthermore it has been applied widely and should be received with great attention and popularity.

Objective: To explore the differences between the internal social adaptation and external social behaviors of freshmen. Methods: Make a survey of 198 freshmen on the internal adaptation and external by General Well-Being Schedule and Undergraduate Social Adaptation Questionnaires. Results:Freshmen' social adaptation mainly involves three factors: interpersonal communication, the state of campus life and performance of studies. The Cronbach alpha of 3 factors were 0.82, 0.87 and 0.90,and the re-test reliability was r=0.73 (P

Cerebral white matter damage is the most common form of brain injury in premature infants,which is the main cause of neurological and mental injury and cerebral palsy.Imaging examination plays an important role in the diagnosis and follow-up of white matter damage.Because of the safe and accurate characteristics,nuclear magnetic resonance has become the most common imagine form.Different from the traditional nuclear magnetic resonance technique,diffusion tensor imaging (DTI) can get quantitative analysis of cerebral white matter fiber bundle in vivo.This technology has become a powerful tool for the evaluation of white matter damage.The article summarizes the application of DTI in the neurodevelopmental evaluation of cerebral white matter damage in premature infants.

Objective To explore the clinical value of adenosine deaminase (ADA),C-reactive protein (CRP)and carcinoembry-onic antigen (CEA)in the diagnosis of pulmonary tuberculosis(TB)and extrapulmonary tuberculosis (EPTB).Methods ADA was measured with the liquid dual reagent velocity method,CRP with the gold-labeled immunization test and CEA with ELISA.90 a-dults were as controls,94 cases of pulmonary TB as the pulmonary TB group and 73 cases of EPTB as the EPTB group.The ADA, CRP and CEA levels were compared among 3 groups.Results The levels of ADA,CRP and CEA in the pulmonary TB group and the EPTB group were (50.1±24.4)U/L,(53.6±21.3)mg/L and (8.7±3.4)μg/L;(49.2±23.5)U/L,(49.8±19.8)mg/L and (8.5±3.3)μg/L respectively,which were significantly higher than (17.1±5.1)U/L,(8.7±2.5)mg/L and (5.4±2.3)μg/L in the control group,the differences had statistical significance (P<0.05).The positive rates of ADA and CRP were 91.5% and 89.4% in the pulmonary TB group and 84.9% and 91.8% in the EPTB group,which were higher than 2.2% and 1.1% in the con-trol group,the difference was statistically significant (P<0.05).Conclusion The measurement of ADA,CRP and CEA is of high clinical value in the diagnosis and differential diagnosis of pulmonary TB and EPTB.

Objective:To investigate the expression of beta-catenin,protein APC and its implication in ovarian epithelial tumor.Methods:Immunohistochemical staining with ABC method was conducted to determine the expression of beta-catenin and protein APC in 48 cases of ovarian epithelial tumors.Results:The rate of beta-catenin in ovarian malignant epithelial tumor was higher than that in benign epithelial tumor,and the rate in borderline epithelial tumor was higher than that in benign epithelial tumor too.There was significant difference between them.The prevalence of protein APC positive in ovarian benign epithelial tumor was significantly greater than that in ovarian malignant epithelial tumor.A significant negative correlation was found between beta-catenin and protein APC in ovarian epithelial tumor.Conclusion:The results suggest that beta-catenin and APC protein have important effects on pathogenesis and development of ovarian epithelial tumors.

Objective:To explore the effects of ablation of normal rabbit liver tissue by combination of high intensity focused ultrasound(HIFU) and iodized oil emulsion(HIFU liposome 2,HL-2) and the grey scale changes in target region.Methods:Rabbit liver was ablated with HIFU under certain parameters one hour after HL-2 was injected intravenously in the experimental group.The grey scale in target region and the exposure time were recorded.All processes in control group were the same as those in the experimental group only HL-2 was replaced by saline.Results:The changes of grey scale in the target region were similar in two groups.Typical coagulation necrosis happened both in two groups under gross and histological examination.The energy efficiency factor (EEF)in the experimental group was less than that in the control group(P