Objective To explore the antagonistic effect of Schistosoma japonicum soluble adult worm antigen (SWA)and solu-ble egg antigen (SEA)in the mice with type 1 diabetes.Methods The 24 successful modeling type 1 diabetes mice were randomly divided into three groups (A,B,C group,n=8).SWA and SEA of Schistosoma japonicum were prepared.Mice in A group were immunized by abdominal subcutaneous multi-point injection SWA.Mice in B group were immunized by abdominal subcutaneous multi-point injection SEA.And mice models of C group were immunized by PBS instead of antigen through abdominal subcutaneous injection.The mice got immunization once a week,a total of four times.4 weeks later,the mice were sacrificed,and serum speci-mens were collected for the determination of serum levels of IL-4 and IFN-γby double-antibody sandwich ELISA,while pancreas tissues were collected and the pathological changes were observed.Results The serum IL-4 level of B group [(23.87 ±4.85)pg/mL]was higher than C group [(4.39 ± 0.56 )pg/mL],with significant differences (P < 0.01 ),while the serum IFN-γ level [(271.85±26.04)pg/mL]was lower than C group [(362.79 ±32.50)pg/mL],also with significant differences (P <0.01).The serum IL-4 and IFN-γof A group were (5.09±0.37)pg/mL and (379.56±34.47)pg/mL,which had no difference with C group (P >0.05).The islet structure of mice in B group was not intact,however,the lymphocytic infiltration in B group was less than C group,and there was no lymphocytic infiltration in pancreatic islets in B group.Compared with C group,the pancreas of mice in A group did not have significant changes,lymphocytes infiltration was still visible in islets.The number of residual islet cells de-creased,and visible minority islet structure was destroyed.Conclusion SEA of Schistosoma japonicum has certain antagonism effect on type 1 diabetes in experimental mice.Its mechanism may be the reduction of Th1 response and the enhancement of Th2 response through increasing IL-4 level and decreasing IFN-γlevel.

Basic research in interventional radiology,including transcatheter artery perfusion especially,is progressing slowly due to lack of proper method.Microdialysis technique,a kind of accurate sampling technique in vivo,may help to solve the problem.Just as its name implies,microdialysis means tiny dialysis with advantages of authenticity,exactness and less error.Furthermore it has been applied widely and should be received with great attention and popularity.

The articles concerning intensive effect and progress of interventional therapy for hepatocellular carcinoma (HCC) recurrence were comprehensively reviewed. Along with unceasing abundance of all interventional methods (including transcatheter arterial chemoemblization (TACE),percutaneous dehydrated ethanol injection,radio frequency ablation,percutaneous microwave therapy,argon-helium cryoablation,high-intensity focused ultrasound and radionuclide interventional therapy,etc),combined interven-tional therapies mainly TACE were increasingly appreciated in postoperative HCC recurrence,but still have to be further standardized. With further emerging and maturing of new technologies,such as antiangiogenesis,gene therapy and targeted therapy on HCC metastatic and recurrence specific cycle; the effect of combined therapy will be further promoted. Interventional therapy will play an important role in the prevention and treatment of postoperative HCC recurrence in the foreseen furture.

Objective:To study the cognitive features of text anxiety. Methods: The cognitive features of text anxiety were explored by exploratory factor analysis and confirmatory factor analysis on the basis of interview,questionnaire surveying and criterion.Results:There were 6 cognitive factors leading to test anxiety: self-test, worrying, magnifying conclusion, resistance, preparing, self-efficacy.Conclusion: The 6 factors of cognition about text are related to text anxiety

Objective: To explore the differences between the internal social adaptation and external social behaviors of freshmen. Methods: Make a survey of 198 freshmen on the internal adaptation and external by General Well-Being Schedule and Undergraduate Social Adaptation Questionnaires. Results:Freshmen' social adaptation mainly involves three factors: interpersonal communication, the state of campus life and performance of studies. The Cronbach alpha of 3 factors were 0.82, 0.87 and 0.90,and the re-test reliability was r=0.73 (P

The interventional therapy of chemoembolization is the first management of choice in treating unresectable hepatic carcinomas but with some side effects including liver function damage and bone marrow restraints which may affect the patients'life expectancy and living quality in the long run.The advancement of the combination of interventional treatment with Chinese drugs in managing liver carcinomas is a special presentation by the auther for further recommondation.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Female ; Humans ; Ileus ; complications ; Intestinal Diseases ; etiology ; pathology ; therapy ; Tissue Adhesions ; pathology ; therapy

OBJECTIVE:To summarize clinical application of various spinal implants to explore the effect of fixator implantation in spine or limbs on MRI.METHODS:A computer-based online search of PubMed database(http://www.ncbi.nlm.nih.gov/PubMed)and CNK1(www.cnki.net/index.htm)was performed to search related articles with the key words"spinal,implants,MRI"in English and Chinese.Articles related with spinal implants and MRI were selected,published in recently or in authoritative journals in the same field.Repetitive or outdated articles were excluded.Finally,24 articles were included RESULTS:During spinal reconstruction,autologous lilac bone block and fibula have been commonly used as bone graft.However.bone graft acquisition frequently causes 20%-30%donor region complication and long-term donor pain.Therefore,allogenic bone and titanium mesh have been used to replace autologous bone graft However,due to low fusion rate and disease transmission caused by allogenic bone,titanium mesh bone graft has become a focus MRI detection shows that nickel,cobalt and iron have large shadow,and titanium alloy has the smallest shadow.Spinal cord and intraspinal structures are clearly displayed on sagittal T1 and T2 weighted and axial T1-weighted images.Vertebral plate clamp has large shadow,which affects observation of structures around the vertebral plate and the intraspinal structures.Pedicle screws have large shadow,which mainly affects observations of lateral vertebral canal,vertebral artery,intervertebral foramen,spinal nerve and posterior-laterally exserted intervertebral disk.CONCLUSION:There remain no uniform standards or favorable results,which are varied in patients with difierent disease conditions,economic conditions,and in different doctors.Titanium is the best implant for MRI,and implant long axis should be accordant with main field.Titanium alloy implant in the spine should utilize fast spin echo,short echo time,and minimize TE.The diagnosis should consider the shadow in combination with clinical manifestations.

BACKGROUND: With follow-up prolonged, more patients received total hip replacement need to revision. Periprosthetic ostaolysi, accompanied by aspetic loosening, would be aggratate, which lead to artificial joint loosening, eventually, result in joint renovation. OBJECTIVE: To observe the therapeutic effect of non-bone cement prosthesis on joint renovation following total hip replacement. METHODS: Totally 41 patients (41 hips) received renovation following total hip replacement at the Shenyang Orthopaedics Hospital from 2004 to 2009 were selected. They were renovated by Circumflex type total hip joint and press fit type non-bone cement type total hip joints. Eight cases had acetabular deficiency, 17 cases had Gustillo Ⅰ-Ⅱ acetabular loosening, and 8 cases had Gustillo Ⅲ acetabular loosening. All these patients were received spiral mortar shaping of pure titanium directly or combined with particle bone graft. Eight patients had Gustillo Ⅳacetabular loosening combined with bone defects, who adopted particles to plant the bone, rebuilt the hip mortar by titanium mesh, and shaping with bone cement. Non-bone cements prosthesis or lengthened prosthesis, as well as bone graft, was selected individualized. The cerclage band could be used if necessary. RESULTS AND CONCLUSION: Eight patients received titanium mesh and bone graft could do un-bearing exercise, and the remained patients could perform bearing exercise at day 3 after renovation. In the 6-66 months follow-up, no prosthetic displacement or subsidence could be found. No patients need a second renovation. Harris scores were increased from 32.6 before operation to 88.1 after operation. X-ray film showed that the bone density was increased in parts of patients. The results demonstrated that hip renovation using non-bone cement prosthesis can received an excellent short-term therapeutic effect, but the long-term effect needs to be explored.

BACKGROUND: Understanding of patch classification, characteristics, and reaction with host is necessary for best selection of reparative surgery materials.OBJECTIVE: To summarize the patch classification, characteristics and its application in pelvic reconstruction, as well as the complications.METHODS: A computer-based online search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI database (www.cnki.net/index.htm) was performed for related articles with the key words "patch, polypropylene, compound patch" in Chinese and "reconstructive pelvic surgery, repair, replacement" in English. Articles regarding patch classification, characteristics biocompatibility, and application effect, or in the same circle published recently in authoritative journals were included. A total of 24 articles were finally selected.RESULTS AND CONCLUSION: Polypropylene patch is weaved network, with large mesh, which allows for fiber tissue ingrowth and improves tissue intensity and tensile strength. Leukocyte and macrophage can enter the mesh, so the patch has good anti-infection ability. Expanded polytetrafluoroethylene is soft and smooth, with good tissue tolerance, and can prevent affixion with intraabdominal tissues. Moreover, the submicron pore diameter prevents bacteria invasion. The inflammation and foreign body reaction induced by the expanded polytetrafluoroethylene is the most slight among artificial synthetic materials.