Objective To observe the characteristics of magnetic resonance diffusion tensor imaging (MR-DTI)for optic nerves and optic radiation in blind patients. Methods The optic nerves and optic radiation of 20 blind patients (blind group) and 20 controls (control group) were scanned by MR-DTI.Fractional anisotropy (FA) and directional encoded color (DEC) maps were acquired through postprocessing with the aid of volume-one 1. 72 software. The signal intensity of optic nerves and optic radiation were then observed. The FA, mean diffusivity (MD), λ∥ and λ⊥ value of bilateral optic nerves and optic radiation in two groups were measured in the DEC maps. Results While the high signal intensity was found in bilateral optic nerves in FA and DEC maps in control group, the signal decreased markedly in the blind group. The FA and λ∥ value of optic nerves in the blind group were declined obviously compared to that in the control group. The difference was statistically significant (t= 16. 294, 14. 660;P=0. 000). The MD and λ⊥ value of optic nerves in the blind group were increased obviously compared to that in the control group, the difference was also statistically significant (t=8. 096, 8. 538;P = 0. 000). The high signal intensity was found in bilateral optic radiation in FA and DEC maps in both the blind and control groups. There were no statistic differences in FA and MD value in bilateral optic radiation between the blind and control groups (Left:t=1.456,1.811;P = 0. 152,0.076. Right:t = 0. 779,0. 073;P = 0. 440,0. 942). Conclusion A low signal intensity of bilateral optic nerves and a high signal intensity of bilateral optic radiation were found in blind patients.

Objective To observe the clinical effect of maintenance chemotherapy by pemetrexed in advanced non-small-cell lung cancer. Methods 60 patients with advanced non-small-cell lung cancer (stage Ⅲb~ Ⅳ) were randomly divided into observation group and control group , all the patients showed complete or partial remission after receiving 4 cycles of induction chemotherapy. Observation group was given pemetrexed maintenance (500 mg/m2 on days 1 every 21 days) until first disease progression, control group was given best supportive care . Progression free survival ( PFS ) , overall survival ( OS ) and adverse reaction were observed . Results PFS and OS of observation group were significantly higher than control group, PFS was (7.3 ± 1.20) vs (3.5 ± 1.13) months, OS was (12.2 ± 1.14) vs (7.1 ± 1.23) months, the difference was statistically significant. The main side effects were fatigue and leucopenia which were tolerable. Conclusion Maintenance therapy with peme-trexed following initial therapy was feasible, and extended the PFS and OS, and shows a favorable toxicity profile.

Animals ; Dementia, Vascular ; blood ; psychology ; Erythrocyte Count ; Learning ; drug effects ; Male ; Memory ; drug effects ; Peptides ; pharmacology ; Rats ; Rats, Sprague-Dawley

ObjectiveTo explore the influence of 3C bolus wizard on postprandial glucose levels in diabetic patients. MethodFifty-eight patients with type 2 diabetes in our hospital were monitored with continuous glucose monitoring system(CGMS), continuous subcutaneous insulin infusion(CSII)and CareLink(3C for short)for 6 days.The function of “3C” bolus wizard was applied during treatment and all the patients were given dietary nursing and health education.The glucose level was observed.ResultThe level of P2hBG of the 58 patients was between 6.4~10.7mmol/L in 3~6 days.ConclusionsBolus wizard plays an important role in “3C” treatment.It can make the postprandial glucose of patients satisfactorily controlled in a short time only to avoid insulin hypoglycemia because of large doses of insulin.At the same time,health education on patients can achieve remarkable results as well.

Adult ; Humans ; Male ; Neck Injuries ; complications ; Pharynx ; injuries ; Trachea ; injuries

[Objective]To analyze the mechanism of shape memory alloy imrasegmental fixator for lumbar spondylolysis(WMAIF)with finite element method.[Method]The three-dimensional model of WMAIF was established by using ANSYS 8.0 software for large finite element analysis.The model was extended with restriction in different parts,and to undertake corresponding mechanics calculation.[Result]The finite element model of WMAIF was set up,which could predict the strength and displacement of every node and element of its own structure in the course of deforming.[Conclusion]WMAIF is strong enough against tensile stress,which is a new and reliable intrasegmental instrument for direct repairing of lumbar spondylolysis.

ve To explore the levels of boood lead of preschool children in Harbin and their impacts on the growth and development of children. Methods 310 preschool children aged 4~7 years were selected for measurement of height and weight, and for collection of fasting blood samples, determined for concentrations of lead by ICP/ MS assay. The state of lead poisoning in selected subjects was defined based on the blood lead level of ?100?g/L ruled by the standard of children's lead poisoning established by CDC in 1991 and Health Assessment Scale for Growth and Development of Children set by Academy of Preventive Medicine. Results The prevalance rate of lead poisoning a-mong selected preschool children was 14.9%. Significantly negative correlation was observed between the blood lead levels and heights (H), body weights(BW) in children aged 4~5 years (rBw = -0.158, P

Objective To assess the evolution of gastric epithelial dysplasia (GED). Methods We reviewed the history of 239 of patients with gastric dysplasia diagnosed by endoscopic biopsy, and 195 were followed up for 61. 37 months. Results Among 239 cases of dysplasia (261 lesions) , there were 119, with mild dysplasia, 77 with moderate dysplasia, and 43 with severe dysplasia. The gastric dysplasia lesions are mainly in lesser curvature, and its endoscopic appearance mostly is localized erosion. In the follow - up group, regression of dysplasia was demonstrated in 86. 36% , 81. 25% , and 47. 62% of mild, moderate and severe dysplasia respectively. Progression to gastric cancer was detected in 8. 18% , 15. 63% , and 72. 09% of mild, moderate, and severe dysplasia, respectively. The relative risk (RR) of mild, moderate, severe dysplasia was 1. 96, 3. 74, and 17. 25 respectively. Conclusion Carcinomatous evolution of GED increases proportionally with its histological grade. Gastroscopy biopsy follow-up should be held up for all grades of GED, especially, in high grade GED, gastroscopy and biopsy should be taken as soon as possible.

Fibers with different hemicellulose contents were produced using various degree removal of hemicellulose to obtain large differences in cellulose and hemicellulose proportions at a similar lignin content. Solid state cross polarisation magic angle spinning carbon-13 nuclear magnetic resonance(CP/MAS ~(13)C-NMR) and atomic force microscope(AFM) had been employed to investigate the microstructure of fibers. The results showed that there was an increase in relative content of para-crystalline cellulose with the decreas of hemicellulose content obtained by the spectral fitting for the cellulose C1-region(δ 102-108). The elementary fibril size was relatively constant between 4.0 and 4.3 nm for the three samples obtained by the spectral fitting for the cellulose C4-region(δ 80-92). The difference in elementary fibril size between the samples was not significant. However, the elementary fibril aggregate size increased from 17.9 to 22.2 nm with the decreas of hemicellulose content, which was a significant change. The results of AFM analysis showed that the fiber with a high hemicellulose content had a porous surface structure. In fibres with a low hemicellulose content, the elementary fibril aggregates formed a much more compact surface structure. Lower hemicellulose content can promote the partially irreversible microfibril aggregation, which caused tensions in the microfibrils due to the finite dimensions of the cell wall, amounting to stress in the microfibrils. However, the porous structure can be improved as hemicellulose content decreased to a certain extent.

Objective: Our aim was to investigate whether the immune RNA (iRNA) can inhibit the endotoxin-induced uveitis (EIU). Methods: The EIU was induced by injecting endotoxin of E.Coli into rats hypodermically. iRNA was abstracted from the livers and spleens of the rabbits which had been injected by E.Coli six times. The iRNA was introduced intraperitoneally into the rats both at half an hour and 3 hours after the injection of endotoxin. The effect of iRNA was evaluated by protein determination and cell count in aqueous houmer(AH). Results: The appearance of EIU in the iRNA treated rats was delayed, about 3 hours later than the rats received only endotoxin injection. The AH protein decreased by 58.34% and cellular infiltration decreased by 27.62% in iRNA treated group at the 24 hours. Conclusion: The iRNA may partly prevent the development of EIU and significantly reduce the severity of EIU.