BACKGROUND:Reaction velocity for brain imagination is a major criterion in measuring quality of brain computer interface (BCI)system.Therefore,electroencephalogram (EGG) analysis,especially the feature extraction screening,is very important.Reduction the number of features is an important way to improve the speed.OBJECTIVE:To screen EGG features using reduction algorithm,and to decrease the number of EGG features.METHODS:Firstly,by various analytical methods,the EGG features were extracted and classified;then,discreting the continuous EGG to establish an EGG information table;At last,reduction theory was used to reduce EGG features,and to sort the data according to reduced attributes,the accuracy of sorting was validated.RESULTS AND CONCLUSION:Using reduction algorithm and feature marking,discreting the continuous EGG to establish an EGG information table,and then choose the features from the discrete data.The results show that classification accuracy has not been reduced but the number of features was reduced.However,this method can be used marking features in two sorts,how to marking features of multi-sorts and to perform data reduction is a key point in further study.

Diabetes mellitus has become one of the diseases which threaten the heath of human being in the 21st century.A goal of research in diabetes is to find a way to increase the number of functional insulin-producing cells. Islet transplantation has been considered to be the most effective approach to cure type Ⅰ and part of type Ⅱ diabetes mellitus.This approach, however, is severely limited by an inadequate supply of donor islets available for transplantation.Moreover, recent progress of stem cells research has shown that stem cells may act as a new source of islet transplantation in diabetes mellitus treatment. Recent evidence indicates that Glucagon-Like PeptideⅠ(GLP-1) plays a very important role in targeted differentiation of stem cells into Insulin-Producing Cells and pancreatic development. GLP-1 is an intestine-derived insulinotropic hormone that stimulates glucose dependent insulin production and secretion. GLP-1 can induce differentiation of stem cells into insulin-producing cells, which is achieved by up regulation of PDX-1 expression.PDX-1 is a transcription factor critical for pancreatic development and endocrine cell neogenesis and a marker for pancreatic stem cells. These new findings suggest an approach to create Insulin-Producing cells in vitro by expanding stem/progenitor cells and then to convert them into Insulin-Producing cells by treatment with GLP-1. Thus GLP-1 may be a means by which to create Insulin-Producing cells ex vivo for transplantation into patients with insulinopenic type Ⅰ diabetes and severe forms of type Ⅱ diabetes. This article reviews recent progress about GLP-1 and targeted differentiation of stem cells induced by GLP-1.

Objective To establish alcoholic liver disease (ALD) model of rats. Method Rats were given wine by ig for 13 weeks. ALD were assessed by the level of serum glutamic-pyruvic transaminase (ALT), glutamic oxalacetic transaminase (AST), malonaldehyde (MDA) and pathological changes of liver. Result Over-dose wine can increase the level of serum ALT, AST, and MDA, decrease the level of serum albumin (ALB), and induce hepatic steatosis. Conclusion Alcoholic liver disease model of rats can be established by long-time and over-dose wine. The model can be applied in the research of ALD.

Objectives To study the characteristics of VEGFR-3, podoplanin or CD34 positive vessels in colorectal cancer (CRC) and their correlation with metastasis. Methods The characteristics of VEGFR-3, podoplanin or CD34 positive vessels in 96 cases with CRC and normal mucosa were evaluated by single-labeling or double-labeling immunohistochemistry with anti-human VEGFR-3, podoplanin or CD34 antibody respectively, and their relationship with metastasis of the cancer was analyzed. Results The density of VEGFR-3, podoplanin or CD34 positive vessels at the peripheral region of CRC was significantly higher than that of other regions of CRC or that in normal mucosa (P

Diet ; Eating ; Genetic Therapy ; Hemofiltration ; Humans ; Metabolism, Inborn Errors ; genetics ; therapy ; Transplantation

Objective To evaluate the utility of three-dimensional digital subtraction angiography(3D-DSA) in the diagnosis of cerebral vascular diseases.Methods Seventy-one patients suspected and diagnosed with cerebral vascular diseases underwent conventional DSA and 3D-DSA. Three-dimensional (3-D) reconstructed images were obtained at a separate advantage 4.0 workstation after the rotational images were transferred. The available visualization techniques included maximum intensity projection (MIP), shaded surface display (SSD), and virtual angioscopy (VA). Results Sixty-four aneurysms were found in 44 cases. Nineteen cases were diagnosed as cerebral arteriovenous malformation (AVM) and 8 cases of cerebral ischemia were due to cerebral vascular stenosis (internal carotid artery in 6 cases and occlusion of anterior cerebral artery in 2 cases).Conclusions 3D-DSA is reliable, fast and safe for diagnosis of cerebral vascular diseases, especially involving intracanal areurysms AVM and vascular stenosis.

Objective To investigate the mechanism of endothelial cell damage under insulin resistance state induced by high fat-feeding by observations of the effects of antioxidant N-acetylcysteine(NAC) on the blood glucose,lipids,the histological parameters of aorta,and the expression of intercellular adhesion molecules-1(ICAM-1),monocyte chemoattractant protein-1(MCP-1) and NF-?B/I?B? in aortic intima.Methods Forty-five Wistar male rats aged 5 to 6 weeks were randomly divided into 3 groups:control,high fat-feeding(HF) and HF plus NAC treatment(HF+NAC).Blood glucose,insulin,lipids,body weight,visceral fat content,histological change of aorta and the expression levels of ICAM-1,MCP-1 and NF-?B/I?B? were determined after the rats were fed for 11 weeks. Results(1)The body weight,ratio of visceral fat content over body weight,blood glucose,insulin,triglyceride,total cholesterol,LDL-C,and total FFA were significantly increased in HF group after 11 weeks feeding compared with control or HF+NAC(all P

Protamex,flavorzyme and neutrase were used for bienzyme hydrolysis of Mytilus edulis.Protamex and flavorzyme were determined as the optimal hydrolases by analysis of hydrolysis effects.After bienzyme hydrolysis,ester forming yeast fermentation was used to prepare seasoner.The effects of fermentation of single or compound strains on the value of FAN were detected by formaldehyde titration method.The results showed that the value of FAN was 0.65% when the conditions of ester forming yeast 1274 were as follows:inoculation volume 5%(v/v),fermentation temperature 28℃ and culture time 72h after bienzyme hydrolysis;the value of FAN was 0.78% when the hydrolytic solution was fermented by compound strains including ester forming yeast 1274 and 1202 under the same fermentation conditions.After fermentation of ester forming yeast,the seasoner gave a full-bodied smell of ester with fermentation flavour.

Objective To analyze the clinical features,epidemiologic information and outcome in confirmed cases of human infection with a highly pathogenic influenza A(H5N1).Methods The clinical features and epidemiologic findings in 2 confirmed cases of avian influenza A(H5N1)in Anhui province,in November 2005.Clinical data on vital signs,physical findings,laboratory tests and roentgenology were obtained by means of retrospective review of the hospital records.Epidemiologic data were collected through interviews of the patients and their relatives.Results In both cases,the diagnosis of influenza A(H5N1)was confirmed by means of viral culture and real-time polymerase chain reaction with specific primers for H5 and N1 in samples obtained from tracheal aspiration.All patients were previously healthy young women and resided in village.They had a clear history of di- rect contact with sick/dead poultry and prepared dead chickens at home for eating(removed feathers, washed,cut)hut no report of confirmed HSN1 animals in the village.The time between exposure and onset of illness were 5 days,no one else in family sick.The time between the onset of illness and hos- pitalization were 5 days and 6 days,respectively.Two patients have initial symptoms of high fever (typically a temperature more than 38℃).The prominent clinical features were those of influenza syndrome,including fever,cough,and shortness of breath.Upper respiratory tract symptoms were absent.The platelet counts were decreased.In both patients,there were marked abnormalities on chest radiography,radiographic changes include bilateral and unilateral lobular consolidations with air bronchograms,and had dramatic worsening of findings.Two patients developed acute respiratory dis- tress syndrome(ARDS)complicated multiple organ dysfunction syndrome(MODS)and died of pro- gressive respiratory failure.Conclusions Exposure to dead poultry within a week before the onset of illness was associated with Influenza A(H5N1)infection in humans,but no definitive evidence of hu man-to-human transmission has been found yet.Influenza A(HSNI)infection,characterized by fe- ver,an influenza-like illness with lower respiratory tract symptoms,carries a high risk of death.

By introducing an electro-withdrawing antipyrine group, N-(p-toluenesulfonyl)-N-(4-antipyrine)-10-methylacridinium-9-carboxamide triflate was prepared. The UV, FL and CL properties of the target compound and of its precursor were investigated by comparing with those of the model compound N-(p-toluenesulfonyl)-N-phenyl-10-methylacridinium-9-carboxamide triflate and the corresponding precursor respectively. The results show that acridine sulfonamide with a heterocyclic antipyrine group exhibits blue shift of both UV absorption and of maximum excitation wavelength(λex) and emission wavelength(λem) in FL spectra, comparing with the corresponding model compound. The λex of the final target and its precursor are 268 and 274 nm, respectively; and the λem are 321 and 327 nm, respectively, while λex of the model compound and its unmethylated precursor are 365 and 359 nm, respectively; and the λem are 504 and 440 nm, respectively. Moreover, the chemiluminescence of the final target compound triggered by H2O2 could finish within 1.1 s; and the quantum yield is similar to that of the model compound, being 5.6 times high as that of luminol.