1.Effects of Helium-oxygen Mechanical Ventilation on Histomorphology in ALI Animal Models
Xiongjian XIAO ; Jiandong LIN ; Guo LIN
Journal of Medical Research 2006;0(04):-
Objective To investigate the effect of Helium-oxygen mechanical ventilation on histomorphology in acute lung injury(ALI)animal models.Methods To investigate the changes of histomorphology in ALI rat models caused by sepsis by comparing air-oxygen mixture mechanical ventilation with helium-oxygen mixture mechanical ventilation.Results Helium-oxygen mechanical ventilation has no influence on the change of lung histomorphology.Conclusion Helium-oxygen mixture mechanical ventilation could not improve lung histomorphology.Helium-oxygen mixture mechanical ventilation has no protective effect on ALI animal models.
2.Effects of Helium-oxygen Mechanical Ventilation on Respiratory Mechanics and Oxygenation in ALI Animal Models.
Xiongjian XIAO ; Jiandong LIN ; Guo LIN
Journal of Medical Research 2006;0(09):-
Objective To investigate the effects of Helium-oxygen mechanical ventilation on respiratory mechanics and oxygenation in ALI animal models.Methods To investigate the changes of respiratory mechanics and oxygenated indexs in acute lung injury rat models caused by sepsis at different PEEP by comparing air-oxygen mixture mechanical ventilation with helium-oxygen mixture mechanical ventilation.Results 1.Helium-oxygen mechanical ventilation could not improve respiratory mechanical indexs in ALI animal models(airway peak pressure、mean airway pressure、platform pressure、dynamic compliance、airway resistance、flow rate of peak value).On the contrary,in the condition of high level of PEEP,some indexs became worse,such as depress of dynamic compliance(P
3.A second ERCP for the failure of pre-cut ERCP
Xiao ZHANG ; Yinghui GUO ; Xiuying LIN
Chinese Journal of Digestive Endoscopy 2014;31(4):210-212
Objective To study the therapeutic value of a second ERCP for the patients with failure of pre-cut ERCP.Methods A total of 167 cases of pre-cut ERCP failure were recruited to the study,among which 109 cases were diagnosed as common bile duct stones and/or benign papillary stenosis,and 58 cases as biliopancreatic lesion.ERCP failed with standard intubation for more than 20 minutes,even with pre-cut or fenestration.A second ERCP was preformed after rest of 3-5 days.The position sequence of intubation for most patients was horizontal,the front and rear.Results The success rate was 79.6% (133 cases) for the patients with a second ERCP,85 patients received the procedures via the horizontal intubation,36 via anterior,and 12 via posterior intubation.The treatments were performed after successful completion of the endoscopic cannulation.One patient had retroperitoneal infection with duodenal perforation,another patient had severe pancreatitis,who were cured by the intervention methods.Conclusion The success rate of a second ERCP is high with proficient intubation skills.
5.Genealogy of mucopolysaccharidosis II.
Li-lin GUO ; Yan-lin ZHU ; Xiao-wei YAN
Chinese Journal of Cardiology 2013;41(5):438-439
Adolescent
;
Child
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Child, Preschool
;
Female
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Humans
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Male
;
Mucopolysaccharidosis II
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genetics
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Pedigree
6.A case of child myiasis.
Guo-guang XIAO ; Jian-jun DENG ; Lin LIAO
Chinese Journal of Pediatrics 2010;48(9):719-719
Child, Preschool
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Humans
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Male
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Myiasis
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diagnosis
7.Detection of expressions of Ck2α,β-catenin and survivin in ovarian cancer tissue and its clinical application value
Shuang WU ; Yimeng LIU ; Chao LIU ; Lin GUO ; Jianying XIAO
Journal of Jilin University(Medicine Edition) 2014;(6):1256-1260
Objective To study the expressions of casein kinase 2α(Ck2α),β-catenin, survivin in ovarian cancer tissue and analyze the relationships between them, and to explore the clinical application value. Methods Immunohistochemistry staining was used to detect the expressions of Ck2α,β-catenin and survivin in 8 cases of simple ovarian cysts tissue,8 cases of ovarian benign tumor tissue and 29 cases of ovarian cancer tissue;the correlations of the expressions of Ck2α,β-catenin,survivin in ovarian cancer tissue and their associations with the clinicopathologic characteristics were analyzed.Results The expression levels of Ck2α,β-catenin and survivin in ovarian cancer tissue were significantly higher than those in simple ovarian cysts tissue and ovarian benign tumor tissue(P<0.05);the Ck2αexpression level in ovarian cancer tissue was positively corelated with the expression levels ofβ-catenin and survivin(r=0.438,r=0.479,P<0.05);the expression levels of Ck2α,β-catenin and survivin in low-medium differentiation group were significantly higher than those in high differentiation group (P<0.05);the expression levels of Ck2α,β-catenin and survivin in stagesⅡandⅢ group were significantly higher than those in stage Ⅰ group(P<0.05).Conclusion The protein expression levels of Ck2α,β-catenin and survivin are increased in ovarian cancer tissue, and three are positive corelations between them;Ck2α,β-catenin and survivin may play an important role in the occurrence and development of ovarian cancer;the combined detection of them has important clinical value.
8.Approach to the patient of subacute thyroiditis combined with Graves' disease
Lian HUANG ; Xiangjin XU ; Yiyang LIN ; Wen GUO ; Jianpeng XIAO
Chinese Journal of Endocrinology and Metabolism 2015;31(4):363-365
Simultaneous concurrence of subacute thyroiditis and Graves' disease is rare.We present one case of subacute thyroiditis with Graves' disease and combine with other reports to explore the clinical characteristics and therapeutic considerations.If subacute thyroiditis is considered coexisting simultaneously with Graves' disease,radioactive iodine uptake,thyroid autoantibody,fine-needle aspiration of thyroid gland,thyroid nuclide imaging examination,etc,should be done to make correct diagnosis and to adjust the therapeutic plan.
9.Novel nerve cell scaffold materials for repair of spinal cord injury Current appfications and future prospects
Nan LIANG ; Xianfeng WANG ; Xiao ZHANG ; Guo CHEN ; Lin OU
Chinese Journal of Tissue Engineering Research 2009;13(25):4993-4996
At present, the research regarding repair of spinal cord mainly focuses on tissue engineering. Neural tissue engineering materials provide three-dimensional template for tissue regeneration and also environment for synthesis of extracellular matrix. This paper summarizes the types of nerve transplant materials and the research progress in application for treatment of spinal cord injury, so as to provide theoretical evidence for repair of spinal cord injury. But some problems exist in application of nerve cell scaffold materials for repair of spinal cord injury: poor mechanical properties lead to slow degradation speed, causing difficulties in tissue reconstruction with respect to velocity and in subsequent reconstruction of porous three-dimensional scaffold. In recent years, novel biomaterials with specific repair function have been made by the engineering method through combining the biological molecule with specific signal identification function and available materials, which is an advanced projeot in the current field of biomaterials.
10.Capillary electrophoresis with inhibited electrochemiluminescent detection for the trace analysis of epinephrine and dopamine
Xueyang XIAO ; Longhua GUO ; Bin QIU ; Zhenyu LIN ; Guonan CHEN
Journal of Pharmaceutical Analysis 2010;22(2):77-82
In this paper, a novel electrochemiluminescent (ECL) detection approach was developed for highly sensitive detection of ECL inhibitors based on the ECL inhibition of Ru(bpy)32+/2-(Dibutylamino)ethanol (DBAE) system. A microfluidic ECL detection cell was fabricated to couple with the capillary electrophoresis system, the electrochemical system and the postcolumn injection system. Both Ru(bpy)32+ and DBAE solutions were injected directly to the working electrode surface by a micro-infusion system to obtain a high and stable ECL signal. The performance of this setup was demonstrated by the analysis of two typical ECL inhibitors, dopamine and epinephrine. Under the optimal conditions, the limit of detection (LOD) for dopamine and epinephrine was 50nM and 5nM respectively. The proposed method was also successfully used for the trace analysis of dopamine and epinephrine in human serum samples.