3.Strychnine nitrate' effect on intracellular potentials of Mauthner cell evoked by skin stimulation in the crucian carps.
Li-juan ZHANG ; Xue-hong TONG ; Xiao-yi LI
Chinese Journal of Applied Physiology 2005;21(2):169-230
Animals
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Carps
;
physiology
;
Galvanic Skin Response
;
drug effects
;
physiology
;
Skin
;
cytology
;
Strychnine
;
pharmacology
;
Synaptic Transmission
;
drug effects
;
physiology
4.Mechanisms of resistance to crizotinib in patients with transforming EML4-ALK fusion gene.
Hui-juan ZHANG ; Xiao-tong ZHANG ; Li ZHANG
Chinese Journal of Pathology 2012;41(12):862-864
Apoptosis
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drug effects
;
Benzoquinones
;
pharmacology
;
Carcinoma, Non-Small-Cell Lung
;
drug therapy
;
metabolism
;
pathology
;
Drug Resistance, Neoplasm
;
HSP90 Heat-Shock Proteins
;
antagonists & inhibitors
;
Humans
;
Lactams, Macrocyclic
;
pharmacology
;
Lung Neoplasms
;
drug therapy
;
metabolism
;
pathology
;
Mutation
;
Oncogene Proteins, Fusion
;
antagonists & inhibitors
;
genetics
;
metabolism
;
Protein Kinase Inhibitors
;
therapeutic use
;
Pyrazoles
;
therapeutic use
;
Pyridines
;
therapeutic use
;
Triazoles
;
pharmacology
6.Chemical constituents from Pleione yunnanensis.
Xiao-Juan WANG ; Bao-Song CUI ; Chao WANG ; Shuai LI
China Journal of Chinese Materia Medica 2014;39(5):851-856
This study was to investigate the chemical constituents from pseudobulbs of Pleione yunnanensis, one of the source of traditional Chinese medicine "Shancigu". The chemical constituents were isolated by various chromatography methods, including silica gel, ODS, Sephadex LH-20, and semi-preparative HPLC. Fourteen compounds were isolated and identified from the EtOAc fraction of 90% ethanol extract, including five dihydrophenanthrenes, four bibenzyls, two triterpenoids, and three phenylacrylic acids. Their structures were identified on the basis of the spectral data as 4, 7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (1), 4, 7-dihydroxy-1-(p-hydroxybenzyl)-2-methoxy-9,10-dihydrophenanthrene (2), (2,3-trans)-2-(4-hydroxy-3-methoxyphenyl) -3-hydroxymethyl-10-methoxy-2,3,4,5-tetrahydro-phenanthro[2,1-b]furan-7-ol (3), pleionesin B (4), blestriarene A (5), batatasin III (6), 3, 3'-dihydroxy-2-(p-hydroxybenzyl) -5-methoxybibenzyl (7), 3', 5-dihydroxy-2-(p-hydroxybenzyl) -3-methoxybibenzyl (8), 3,3'-dihydroxy-2,6-bis(4-hydroxybenzyl) -5-methoxybibenzyl (9), triphyllol (10), pholidotin (11), (E) -p-hydroxycinnamic acid (12), (E)-ferulic acid (13), and (E)-ferulic acid hexacosyl ester (14). Compounds 5,10-14 were separated from this plant for the first time.
Drugs, Chinese Herbal
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chemistry
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isolation & purification
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Molecular Structure
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Orchidaceae
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chemistry
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Spectrometry, Mass, Electrospray Ionization
8.In vitro metabolism of glycyrrhetic acid by human cytochrome P450.
Li LIU ; Juan XIAO ; Zhihong PENG ; Yong CHEN
Acta Pharmaceutica Sinica 2011;46(1):81-7
Licorice root has been frequently used as antitode in traditional Chinese medicine. As the main active component of Licorice root, glycyrrhetic acid (GA) is mainly metabolized in liver. This study was designed to investigate the in vitro metabolism of GA by human liver microsomes (HLM) and human recombinant cytochrome P450 (CYP) isoforms. The results indicated that GA was metabolized mainly by CYP3A4. The K(m), V(max) and CL(int) of GA in HLM were 18.6 micromol x L(-1), 4.4 nmol x mg(-1) (protein) x min(-1) and 0.237 mL x mg(-1) (protein) x min(-1), respectively. At concentration up to 50 micromol x L(-1), GA inhibited CYP2C19, CYP2C9 and CYP3A4 enzyme activities with the inhibitory potencies up to 50%.
9.Effect evaluation of experimental design in the experimental teaching of fundamental nursing
Yanhong HAN ; Pingxian HE ; Lanlan XU ; Juan XIAO ; Li SUN
Chinese Journal of Practical Nursing 2010;26(22):15-17
Objective To explore the effect of experimental design in the experimental teaching of fundamental nursing. Methods 168 and 199 baccalaureate nursing students were in the control and experimental group respectively, the control group received traditional experimental teaching method, and the experimental group must complete the experimental design before entering the lab. The teaching effect between the two groups were compared. Results The mean operation score of the experimental group was significantly higher than the control group, the proportion of those students who reflected their teaching method could enhance creative ability, problem-solving ability and practical ability was higher in the experimental group, 100% teachers reflected experimental design could improve operation level, strengthen theoretical knowledge, animate teaching atmosphere. Conclusions Experimental design could arouse students' enthusiasm and initiative to study, advocate them to think and ask.
10.Dedifferentiated chondrosarcoma of rib: report of a case.
Guang-Ye DU ; Xiao-Qiang LI ; Yi-Juan FAN ; Li-Wei LIU ; Ling-Juan LU ; Jun-Bo DONG
Chinese Journal of Pathology 2008;37(12):856-857
Aged
;
Cell Dedifferentiation
;
Chondrosarcoma
;
pathology
;
Humans
;
Ribs
;
pathology