1.Effect of vinpocetine on monoamine transmitters in cerebral of post-stroke depression rats
Sheng XIAO ; Yafang LIU ; Jinsong XIAO
Chinese Journal of Behavioral Medicine and Brain Science 2011;20(4):315-318
Objective To observe the effect of vinpocetine on monoamine transmitters in cerebral of poststroke depression (PSD)rats and to investigate the mechanism of pharmacotherapeutics on PSD. Methods Rats were divided randomly into the sham-operated group,the normal saline group,the low dose of vinpocetine group and the high dose of vinpocetine group. Giving the left middle cerebral artery occlusion, the PSD rat model was established by unexpected chronic mild stress. When the PSD rat model was established, vinpocetine group was given vinpocetine(5mg/kg, 10mg/kg) and the normal saline group was given normal saline. Then the ethological score of depression was evaluated on 14 and 28 days. The monoamine transmitter in the frontal cortex and hippocampus and brainstem were detected by the fluorospectrophotometry. Results On the 28th day after the model establishment,compared with the normal saline group, the ethological score of depression level was decreased obviously. Compared with the normal saline group, vinpocetine could improve the ethological score of depression level of the PSD rat model, and these concentrations of 5-hydoxytrypatarmine ( 5-HT), noradrenalin ( NE ) and dopamine ( DA ) in the frontal cortex, hippocampus and brainstem. The level of NE ( ( 192.4 ± 34.8 ) ng/g, ( 206. 0 ± 41.7 ) ng/g,(91.1 ±23.0) ng/g] ,5-HT( (494. 1 ± 50.7) ng/g, (599.7 ± 39.2) ng/g, (541.7 ± 62.6) ng/g) and DA ( ( 298.6 ± 32.6) ng/g, ( 297.0 ± 38.1 ) ng/g, ( 85.9 ± 24.3 ) ng/g) in the high dose of vinpocetine group were significantly higher than that in the normal saline group ( NE (92.4 ± 17.5 ) ng/g, ( 131.4 ± 34.8 ) ng/g, (49.0 ±13.6)ng/g;5-HT(367.8 ±87.3) ng/g,(498.7 ± 79.6) ng/g, (320.4 ±59.4) ng/g; DA( 106.1 ±23.0)ng/g,(97.0 ±21.7)ng/g, (50.4 ± 13.8 )ng/g)(P < 0.01 ). There were increased obviously by the high dose than the low dose of vinpocetine group. Conclusion Vinpocetine could treat PSD by increasing the level of monoamine transmitters in PSD rats' brain.
2.Observation on the effect of vinpocetine sustained-release capsules on post-stroke depression and recovery of neurological function
Lianghong KUANG ; Sheng XIAO ; Jinsong XIAO
Chinese Journal of Primary Medicine and Pharmacy 2011;18(18):2471-2473
ObjectiveTo observe the effect of vinpocetine sustained-release capsules on post-stroke depression and recovery of neurological function. MethodsA total of 64 patients with acute post-stroke depression were randomly divided into Vinpocetine sustained-release capsules group( 34 cases) and control group(30 cases). Conventional therapy was given to both groups. To the treatment group, vinpocetine sustained-release capsules was given at the same time. Depression status was assessed with Hamilton Rating Depression Scale(HAMD). Meanwhile ,Mimi-Mental State Examination( MMSE), National Institutes of Health Stroke Scale(NIHSS) and Activities of Daily Living(ADL)were given in to both groups. ResultsAfter 6 to 12 weeks' therapy, the total score of HAMD, NIHSS and ADL of Vinpoeetine group were significantly lower than the control group ( all P < 0.05 ), MMSE score increased significantly ( P < 0.05 ) in Vinpocetine group. The curative rate and effective rate of Vinpocetine group were 38% and 91%. It was significantly higher than the 20% and 73% of the control group ( all P < 0.05 ). ConclusionVinpocetine sustainedrelease capsules was effective to treat post-stroke depression. It could improve the emotional state of patients and promote the recovery of neurological function.
5.Clinical analysis of 15 cases of abdominal compartment syndrome.
Sheng-Kui ZHAO ; Xiao-Ming WEI
Chinese Journal of Contemporary Pediatrics 2010;12(2):143-144
Abdomen
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physiopathology
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Child
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Child, Preschool
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Compartment Syndromes
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diagnosis
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mortality
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therapy
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Female
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Humans
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Infant
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Male
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Retrospective Studies
7.One case of ectopic glioma in mastoid.
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2010;45(11):959-959
Choristoma
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Ear Diseases
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Female
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Glioma
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Humans
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Mastoid
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Middle Aged
8.Sheng's acupuncture manipulation at bone-nearby acupoints and the academic thoughts.
Chinese Acupuncture & Moxibustion 2014;34(11):1111-1113
Sheng's acupuncture manipulation at bone-nearby acupoints is a set of needling manipulation of the chief physician of TCM, SHENG Xie-sun, summarized through his over 50 years clinical experiences and on the basis of Internal Classic. Regarding this manipulation, on the premise of acupoint selection based on syndrome differentiation, the acupoints close to bone are possibly selected and punctured, with the needle tip toward bone edge, and followed by the technique to achieve reducing purpose. Clinically, the significant immediate analgesia can be achieved in pain disorders such as headache and toothache. Professor Sheng thought, corresponding to the location of needle insertion and needling depth, the tissue layers of needle tip passing through should be considered specially. The site of needle insertion should be changeable so as to ensure the needle tip reaching the bone. This manipulation for analgesia provides a certain guide for acupuncture study, especially for the mechanism study on acupuncture analgesia.
Acupuncture
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education
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history
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Acupuncture Points
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Acupuncture Therapy
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history
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methods
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Bone and Bones
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physiopathology
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China
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History, 20th Century
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Humans
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Meridians
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Pain Management
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history
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methods
9.Application of mind map in medical computer teaching
Tian WANG ; Sheng YANG ; Yu XIAO
Chinese Journal of Medical Education Research 2015;(3):269-271
Mind map is an effective and intuitive knowledge organization and presentation tool which can help computer teaching commendably. We can use Mind Map to design and organize the whole teaching process, including preparing, designing, guiding, analyzing and reviewing. This way can turns tedious logic of computer teaching into imagery thinking and helps medical students improv-ing their learning effect of computer courses.
10.Prevalence of Extended-spectrum Beta-lactamases and Metallo-beta-lactamses among Chryseobacterium indologenes and Ch.gleum
Jiahe SHENG ; Weiqiang XIAO ; Qingxia XU
Chinese Journal of Nosocomiology 2006;0(05):-
OBJECTIVE To study the incidence of ?-lactamases,mainly the extended-spectrum beta-lactamases(ESBLs) and metallo-beta-lactamases(MBLs) of Chryseobacterium indologenes and Ch.gleum.METHODS Agar dilution method was applied to detect minimal inhibitory concentrations(MIC) to 12 different antibiotics used frequently.Three-dimensional test was used to detect ESBLs and metallo-?-lactamases.The genes of ?-lactamases were amplified with 3 pairs of primers special for Ch.indologenes and Ch.gleum.RESULTS Among the 25 strains of Ch.indologenes and 10 strains of Ch.gleum,68%(17/25) isolates of Ch.indologenes and 90%(9/10)isolates of Ch.gleum were considered as MBLs positive strains,but no isolates were detected for the production of ESBLs.CONCLUSIONS MBLs are the important mechanism of multi-drug resistance for Ch.indologenes and Ch.gleum.