This paper analyzes the distribution and achievements of the Science Foundation for Youth undertaken by female scientists at Peking University Health Science Center from 2002 to 2012.It reveals the importance of the Science Foundation for Youth in the development of female scientists.

Recently the National Science Foundation of China (NSFC) has put forward some measures to promote the development of women science and technology (S&T) talents.The paper analyzes the NSFC funded projects undertaken by women S&T researchers at Pekiing University Health Science Center from 2006 to 2010.To address the problems revealed in the analysis,the paper proposes the suggestions to further develop women S&T talents with the support of National Science Foundation of China.

Objective To evaluate the treatment of acne vulgaris with acupuncture by different methods of point selection.Methods 51 cases of acne vulgaris were randomly recruited into local point selection group,distal point selection group and combination of local and distal point selection group.10 cases of healthy people were recruited for normal control group.Serum arachidonic acid (AA),free testosterone (FT),and sex hormone binding globulin (SHBG) levels were observed in all treatment groups.Results After the treatment,serum AA was (20.56±5.28)μg/L,(18.86±5.70) μg/L and (14.62±3.06) μg/L,while SHBG was (333.31±87.96) nmol/L,(332.02±87.82) nmol/L and (273.02±61.74) nmol/L respectively in local point selection group,distal point selection group and combination of local and distal point selection group,both showing no significant difference than the normal control group (P＞0.05).There was no significant difference in FT value between the combination of local and distal point selection group (5.62± 1.98) nmol/L and the normal control group (P＞0.05).The decrease of AA in the combination of local and distal point selection group was between than the local point selection group (P＜0.01).Conclusion Acupuncture can effectively improve the level of inflammatory factors and androgen of the acne vulgaris.Different methods of point selection of acupuncture on the improvement of some indicators were quite different,which laid the foundation for the best compatibility of acupuncture treatment in acne vulgaris.

Objective To compare and analyze the different clinical features between male and female patients with rheumatoid arthritis (RA), by detecting the gender difference to make clinical decisions. Method The clinical features of 95 male RA patients(MRA) were analyzed and compared with those of 248 female RA patients (FRA) by retrospective analysis method. Results The mean onset age of MRA [18-79 (51.40±15.55) years old] was older than that of FRA[18-75(43.54 ±15.46) years old](P=0.0002). The morning stiffness time of MRA [(1.58 ±1.34) h] was shorter than that of FRA [(2.10 ±1.51) h](P = 0.0357). There was statistical difference in the first involved joint between MRA and FRA (P=0.0170), the prevalence of knee,metatarsonphalangeal joint,shoulder and ankle of MRA was higher than those of FRA, ' but conversely the wrist prevalence of FRA was higher than that of MRA.The prevalence of secondary Sj(o)gren syndrome of MRA(13.68%, 13/95) was rather lower than that of FRA(35.08%, 87/248)(P = 0.0007). MRA had lower positive rate of ANA (2.11% ,2/95) and lower value of IgM [(1.42 ±0.75) g/L] than FRA [(10.48% ,26/248), (1.69 ±0.86) g/L] (P < 0.05). There was no statistical difference between MRA and FRA in articular radiographic changes, most extraarticular manifestations and lab results (P >0.05). Conclusions MRA patients have older onset age and milder articular symptom than FRA patients. The disease severity of MRA is similar to that of FRA. Weighted joints are more involved in MRA. FRA is more inclined to have secondary Sj(o)gren syndrome.

Objective To explore the efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) in the treatment of hepatorenal syndrome (HRS).Methods From January 2009 to December 2012,the clinical data of three type 1 HRS cases and five type 2 HRS cases received TIPS operation were collected.The volume of 24 h urine,liver and renal function,and the occurrence of complications of portal hypertension were recorded and followed-up.Wilcoxon rank sum test was performed for non-normal distributed measurement data.Results TIPS of all the patients was successful and combined with devascularization in four patients.Before operation,the serum creatinine and volume of urine was 204.0 (180.8,229.8) μmol/L and 810 (600,925) mL,seven days after operation was 160.7 (120.2,184.0) μmol/L and 1 300 (975,1 500) mL,respectively,and the differences were statistically significant (Z=-2.1 and-2.2,both P＜0.05).One month after operation,renal function of five patients recovered to normal.At the 7th day after operation,total bilirubin level of three patients increased and that of two patients decreased to the preoperative base line value at one month and three month.Mild or moderate hepatic encephalopathy occurred in three patients after operation and relieved after medicine treatment.At 6th month after operation,two of three type 1 HRS patients survived.Of five type 2 HRS patients,one received liver transplantation at 6th week after operation,three of the left four cases survived at the 6th month after operation.Conclusion After safety and efficacy were evaluated,TIPS may be one of the methods used for the treatment of HRS.

Objective To investigate the plasma PAF-AH level in type 1 diabetes patients and the association between the PAF-AH gene polymorphism and type 1 diabetes mellitus. Methods Plasma PAF-AH in115 type 1 diabetes patients and 106 controls were determined by PAF-AH assay kit, and PAF-AH gene G275A genotypes were detected by PCR-RLFP. Results The activity of plasma PAF-AH in the patients with type 1 diabetes was significantly lower than that in the controls. Compared with control group, the frequencies of the GA genotype on G275A polymorphism were significantly higher than that in T1DM group. Conclusion The activity of plasma PAF-AH in the patients with type 1 diabetes was significantly lower than that in normal controls. The G275A polymorphism of PAF-AH gene might be related to type 1 diabetes mellitus.

Acupuncture Therapy ; Adult ; Diabetes Complications ; microbiology ; therapy ; Female ; Humans ; Middle Aged ; Urinary Tract Infections ; microbiology ; therapy

Objective:To develop the attitudes toward gay men and lesbians in Chinese context.Methods:Based on the sex differences in homosexual researches and the three factors of attitude,the initial Scale included two subscales of gay men and lesbians,and selected items from cognition,emotion and behavior;used the initial scale firstly to test 353 college students,then selected items through 4 methods;secondly,investigated 404 college students and 533 community residents with the ultimate scale in order to assess it in reliability and validity,10 days after the first testing session,193 students were re-tested.Results:Developed the attitudes toward lesbians and gay men scale of 20 items;the test-retest coefficients of total-scale was 0.959,the Cronbach's ? coefficient of the total-scale was 0.898,the split-half reliability was 0.912.Factor Analysis indicated there were three components in the scale including moral judgement,emotional reaction,and social communication.Conclusion:The attitudes toward lesbians and gay men scale has a high reliability and a good validity and can be used in researches of the public Attitudes toward homosexual.

Heated humidified high-flow nasal cannula(HHFNC) is a relatively new noinvasive method for respiratory support,initially used in premature infant apnea.In recent years,the development of HHFNC applications is rapid,and HHFNC is gradually used in older infants and children.Compared to other noninvasive oxygen supply devices,HHFNC can be used effectively in clinic because of its high comfort,good tolerance,easy care,and reducing the rate of endotracheal intubation.

Objective To discuss the MRI feature of meningeal metastasis and correlation of peritumoral brain edema and vascular endothelial growth factor(VEGF)expression.Methods 48 patients with meningeal metas-tasis were observed with plain and enhanced 1 .5 T magnetic resonance imaging scans,surgical removal of the tumor tissues was measured with VEGF immunohistochemistry.Results The patients with MC showed three types MRI fea-ture.The more vascular endothelial growth factor of the tumor tissues expressed,the more peritumoral brain edema (χ2 =33.34,P<0.01 ).Conclusion MRI scanning is necessary for clinical diagnosis in MC.There are positive correlation between the expression of vascular endothelial growth factor of the tumor tissues and peritumoral brain edema(P<0.01).