OBJECTIVE:To investigate clinical efficacy and safety of Teng medicine combined with Gongyankang granules in the treatment of chronic pelvic inflammatory disease(CPID). METHODS:A total of 141 CPID outpatients were selected from our hospital during Jul. 2015-Jun.2016,other patients were divided into control group(65 cases)and observation group(76 cases)ac-cording to random number table. Control group was given Gongyankang granules 9 g orally,bid;observation group additionally re-ceived Teng medicine hot compress on lower abdomen for 30 min until it was cool,once a day,on the basis of control group. Both groups began the medication since third day after the menstrual period,for consecutive 20 d. TCM syndrome,local sign scores and clinical efficacies were compared between 2 groups before and after treatment,and the occurrence of ADR and recur-rence were observed in 2 groups. RESULTS:Before treatment,there was no statistical significance in TCM syndrome scores or lo-cal sign scores between 2 groups (P>0.05). After treatment,TCM syndrome scores and local sign scores of 2 groups were de-creased significantly,and the observation group was significantly lower than the control group,with statistical significance (P<0.05). Clinical total response of observation group were 92.11％,which were significantly higher than 70.77％ of control group, rate recurrence rate of observation group were 2.99％,which were significantly under than 15.79％ of control group,with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Teng medicine hot compress combined with Gongyankang granules show significant efficacy for CPID,can improve TCM syndrome and local sign and reduce recurrence rate with good safety.

Objective To explore the hospital ship crew's awareness of infectious diseases-related knowledge, and to propose training plans accordingly.Methods Totally 75 non-medical crew members working on the hospital ship between November and December 2013 were selected as respondents by convenience sampling, and were investigated with self-designed questionnaires.Results A total of 54 out of 75 crew members (72.0%) worked for medical support on the hospital ship for less than 2 years. Only 3 of them (4.0%) had systematically learned knowledge related to infectious diseases. 88.0% of the crew members needed training to learn relevant knowledge. The average rate of unawareness of basic theoretical knowledge about infectious diseases was 63.2%, that of prevention and protection knowledge was 90.0%, that of sterilizing and isolating techniques was 60.7%, that of professional exposure-related knowledge was 71.6%, and that of professional safety prevention and protection skills was 50.3%.Conclusions The training of knowledge and skills related to infectious diseases for the hospital ship crew is of significance, which will not only secure the subjects of rescue, but also protect themselves against infectious diseases and make sure that their mission of offshore medical support can be completed successfully.

OBJECTIVESTo compare the gene expression profiles of acute promyelocytic leukemia cell line NB(4) before and after 12 hours of realgar treatment using cDNA microarray.

METHODSTwo cDNA probes were prepared through reverse transcription from mRNA of both untreated and realgar treated NB(4) cells. The probes were labeled with Cy3 and Cy5 fluorescence dyes individually, hybridized with cDNA microarray representing 1003 different human genes, and scanned for fluorescent intensity. The genes were screened through the analysis of the difference in two gene expression profiles.

RESULTSThe analysis of gene expression profiles indicates that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in a proteasome degradation pathway. Some genes related to protein synthesis, signal transduction and cell receptors were down-regulated.

CONCLUSIONPSMC2 and PSMD1 genes may play an important role in the apoptosis and partial differentiation of NB(4) cells.

Arsenicals ; pharmacology ; Down-Regulation ; Gene Expression ; drug effects ; Humans ; Leukemia, Promyelocytic, Acute ; genetics ; Oligonucleotide Array Sequence Analysis ; Sulfides ; pharmacology ; Tumor Cells, Cultured ; Up-Regulation