ObjectiveTo observe the curative effect of intensive regulating lipid by atorvastatin in the treatment of unstable angina and its influence on serum high sensitive C-reactive protein(hs-CRP).Methods60 patients with unstable angina were randomly divided into two groups:the routine treatment group( basic treatment plus atorvastatin 10mg/d),the atorvastatin intensive treatment group( basic treatment plus atorvastatin 40mg/d.)The courses of treatment were both 8 weeks.The differences in the amount of serum hs-CRP,blood fat,the effect of electrocardiogram and the use of glyceryl trinitrate before and after the treatment were observed and compared.Results The differences in the angina curative effect and the amount of serum hs-CRP between the two groups were statistically sig nificant( all P ＜0.05 ).ConclusionShort-term intensive regulating lipid by statins was effective in treating unstable angina,and could quickly relieve the phlogosis in the vessels,prevent the unstable plaque from breaking and the thrombopoiesis,and thus prevent the occurrence of cardiovascular disease.