Objective To investigate the relationship of the occurrence of sinusitis with nasal septum devia-tion.Methods 102 patients with nasal septum deviation confirmed by spiral CT and sinus endoscopy were included. The coronal CT images of all cases were observed.The incidence of sinusitis in different type of nasal septum deviation was calculated and the correlation between sinusitis with nasal septum deviation was analyzed.Results Among 102 patients with nasal septum deviation,deviated septum at high position in 71 cases,deviated septum beyond high position in 31 cases.Sinusitis was detected in 67 cases,accounted for 65.6%,of which unilateral involving in 38 cases,bilateral involving in 29 cases.Main lesions in the nasal septum deviation concave side in 46 cases (68.7%),in nasal septum convex side in 12 cases (17.9%).Conclusion Deviated septum is an important factor in onset.Upper septum deviation and deviated concave side more likely arise sinusitis.

The histological changes in tibial lengthening with metaphyseal osteotomy were observed in 30 goats.It was found that (1) slow lengthening rate of 1 mm/day could enable the tissues to adapt the mechanical traction,and consequently the limitation of elongation could be increased;(2) the new bone formed in the lengthened region might be the result of a combined osteogenesis from endochondral,intramembranous,and fibrous tissue ossification;and (3)the osteogenetic process could be distinguished into 3 stages of hemorrhage and organization of the hematocele,callus formaton,and remodelling of the new bones.

The purpose of this study was to fabricate decelluarized valve scaffold modified with polyethylene glycol nanoparticles loaded with transforming growth factor-β1 (TGF-β1), by which to improve the extracellular matrix microenvironment for heart valve tissue engineering in vitro. Polyethylene glycol nanoparticles were obtained by an emulsion-crosslinking method, and their morphology was observed under a scanning electron microscope. Decelluarized valve scaffolds, prepared by using trypsinase and TritonX-100, were modified with nanoparticles by carbodiimide, and then TGF-β1 was loaded into them by adsorption. The TGF-β1 delivery of the fabricated scaffold was measured by asing enzyme-linked immunosorbent assay. Whether unseeded or reseeded with myofibroblast from rats, the morphologic, biochemical and biomechanical characteristics of hybrid scaffolds were tested and compared with decelluarized scaffolds under the same conditions. The enzyme-linked immunosorbent assay revealed a typical delivery of nanoparticles. The morphologic observations and biological data analysis indicated that fabricated scaffolds possessed advantageous biocompatibility and biomechanical property beyond decelluarized scaffolds. Altogether this study proved that it was feasible to fabricate the hybrid scaffold and effective to improve extracellular matrix microenvironment, which is beneficial for an application in heart valve tissue engineering.

The purpose of this study was to fabricate decelluarized valve scaffold modified with polyethylene glycol nanoparticles loaded with transforming growth factor-β1 (TGF-β1),by which to improve the extracellular matrix microenvironment for heart valve tissue engineering in vitro.Polyethylene glycol nanoparticles were obtained by an emulsion-crosslinking method,and their morphology was observed under a scanning electron microscope.Decelluarized valve scaffolds,prepared by using trypsinase and TritonX-100,were modified with nanoparticles by carbodiimide,and then TGF-β1 was loaded into them by adsorption.The TGF-β1 delivery of the fabricated scaffold was measured by asing enzyme-linked immunosorbent assay.Whether unseeded or reseeded with myofibroblast from rats,the morphologic,biochemical and biomechanical characteristics of hybrid scaffolds were tested and compared with decelluarized scaffolds under the same conditions.The enzyme-linked immunosorbent assay revealed a typical delivery of nanoparticles.The morphologic observations and biological data analysis indicated that fabricated scaffolds possessed advantageous biocompatibility and biomechanical property beyond decelluarized scaffolds.Altogether this study proved that it was feasible to fabricate the hybrid scaffold and effective to improve extracellular matrix microenvironment,which is beneficial for an application in heart valve tissue engineering.