Objective To investigate the effect of emergency nursing process improvement on the treatment of AMI patients with thrombolysis.Methods A total of 45 AMI patients treated by thrombolysis with emergency nursing process were as observation group.And 40 patients with conventional nursing process were as control group.Thrombolytic effect,thrombolytic efficiency,complications,hospitalization time,the rate of myocardial infarction and nursing satisfaction were compared.Results The time of admission to thrombolysis and the time of admission to the emergency room in the observation group were shorter than that in the control group,and the difference was statistically significant (P ＜ 0.05).The re-canalization rate in the observation group was higher,the complication rate and the recurrence rate were lower than that in the control group,but there was no statistical significant difference (P ＞ 0.05).The hospitalization time in the observation group was shorter than that in the control group,nursing satisfaction was higher than that in the control group,and the difference was statistically significant (P ＜ 0.05).Conclusion Emergency nursing process improvement can improve the thrombolytic effect,reduce complications,and shorten the length of stay.

Objective To investigate the effect of emergency nursing process improvement on the treatment of AMI patients with thrombolysis.Methods A total of 45 AMI patients treated by thrombolysis with emergency nursing process were as observation group.And 40 patients with conventional nursing process were as control group.Thrombolytic effect,thrombolytic efficiency,complications,hospitalization time,the rate of myocardial infarction and nursing satisfaction were compared.Results The time of admission to thrombolysis and the time of admission to the emergency room in the observation group were shorter than that in the control group,and the difference was statistically significant (P ＜ 0.05).The re-canalization rate in the observation group was higher,the complication rate and the recurrence rate were lower than that in the control group,but there was no statistical significant difference (P ＞ 0.05).The hospitalization time in the observation group was shorter than that in the control group,nursing satisfaction was higher than that in the control group,and the difference was statistically significant (P ＜ 0.05).Conclusion Emergency nursing process improvement can improve the thrombolytic effect,reduce complications,and shorten the length of stay.

OBJECTIVE: To investigate the effects of serum from the obesity patients and obesity patients with Diabetic mellitus on toll-like receptor 4/Nuclear factor -κB p65 (TLR/NF-κB) pathway in human THP-1 monocytes and to explore the inflammatory immune response in obesity. METHODS: Peripheral serum was isolated from healthy volunteers (the control group), the obesity patients (Ob group) and the obesity patients with diabetic mellitus (the Ob with DM group), respectively, 20 in each group. THP-1 monocytes were incubated with the serum for 48 h. The monocytes and culture supernatant were collected. The phosphorylation level of NF-κB p65 protein in THP-1 monocytes was evaluated by Western blot as well as immunofluorescence assay. The TLR4 mRNA expression was evaluated by RT-PCR. ELISA was used to measure the monocyte chemotactic protein-1 (MCP-1) levels in the culture supernatant. RESULTS: In the presence of serum, the obesity group and the obesity with diabetic mellitus group showed the up-regulated phosphorylation level of NF-κB p65 protein and TLR4 mRNA expression in THP-1 monocytes compared with the healthy control group (both P<0.05), and the MCP-1 levels in the obesity patients were up-regulated significantly compared with the healthy control group [healthy control group (26.4 ± 3.9) pg/mL, Ob group (45.8 ± 10.0) pg/mL, Ob with DM group (58.0 ± 15.3) pg/mL; P<0.05]. These parameters were further up-regulated in the obesity patients with diabetic mellitus patients. CONCLUSION The serum from the obesity patients or the obesity patients with diabetes can induce monocyte dysfunction, which might be related to the activation of TLR4/NF-κB signaling pathway.
Cell Line ; Chemokine CCL2 ; Diabetes Mellitus ; blood ; Humans ; Monocytes ; cytology ; metabolism ; Obesity ; blood ; Phosphorylation ; Serum ; Signal Transduction ; Toll-Like Receptor 4 ; metabolism ; Transcription Factor RelA ; metabolism ; Up-Regulation