Objective To investigate the role of NF-?B in acute lung injury following intracerebral hemorrhage. Methods Using stereotactic apparatus we infused autologous blood into the caudate nucleus to build up rat ICH model. A total of 35 male adult Wistar rats were randomly divided into sham-operation group(n=5) and hemorrhage group(n=30) that was subsequently divided into 6 subgroups (6 h,12 h,24 h,48 h,3 d,and 5 d,n=5). The inflammatory reaction degrees in the peripheral tissues of hematoma in the brain and lung were observed after HE staining. The levels of NF-?B p65 mRNA in the brain and lung were assayed using RT-PCR. The content of TNF-? and IL-1? in serum was determined by radioimmunoassay (RIA) method. Results Brain edema was obvious at 12 h after intracerebral hemorrhage and the inflammatory cells infiltration increased at 24 h and reached maximum at 48 h in the peripheral tissues of hematoma. Interstitial pneumonia and local emphysema appeared at 6 h and got to peak at 48-72 h,in which alveolar structure was significantly destroyed. In comparison with sham-operation group,the expression of NF-?B p65 mRNA began to increase at 6 h in brain and lung tissues (P

Objective To discuss of the therapeutic effects of treating three TCM types of Chronic superficial gastritis (CSG)disharmony of liver and stomach, weakness of the spleen and the stomach, and damp heat in the spleen and the stomach with chinese medicine, and to discuss its impact on the changes of three gastrointestinal hormones-- motilin (MTL), gastrin (GAS), and somatostatin (SS). Methods The data of 150 CSG patients in Shenzhen Bao’an Hospital from Feb, 2011 to Mar, 2013 were selected. These patients belonged to three kinds of syndrome, which was disharmony of liver and stomach, weakness of the spleen and the stomach, and damp heat in the spleen and the stomach, each syndrome had 50 cases. Different Chinese medicines were applied to different syndrome of patients. After one month treatment, the therapeutic effects and the changes of MTL, GAS, SS in these patients were detected by radioimmunoassay. Results After treatment, the total effective rate of the damp heat in the spleen and the stomach syndrome was 94%, the weakness of the spleen and the stomach type was 88%, disharmony of liver and stomach type was 90%, the difference was not statistically significant among the three types(χ2=3.84, P>0.05);after treatment, the serum MTL, SS level of disharmony of liver and stomach, weakness of the spleen and the stomach, and damp heat in the spleen and the stomach type were [damp heat in the spleen and the stomach type were (240.25±7.29)pg/ml, (68.23± 5.97)pg/ml;the weakness of the spleen and the stomach type were (260.16±8.84)pg/ml, (75.35±4.65)pg/ml;disharmony of liver and stomach type were(258.32±15.23)pg/ml, (80.12±7.88)pg/ml] higher than before treatment [damp heat in the spleen and the stomach type were (87.26±7.58)pg/ml, (49.34±4.93)pg/ml;the weakness of the spleen and the stomach type were (67.11±7.81)pg/ml, (57.15±5.11)pg/ml; disharmony of liver and stomach type were (89.26±7.60)pg/ml, (40.63±7.26)pg/ml], and the levels of serum GAS [(156.38±17.36)pg/ml, (146.15±15.56)pg/ml, (140.26±13.37)pg/ml] was lower than before treatment [(274.59 ± 17.82)pg/ml, (320.83 ± 15.02)pg/ml, (216.15 ± 13.77)pg/ml], the difference was statistically significant (P<0.05 or 0.01). Conclusions The changes of three hormones-MTL, GAS, SS can be used as an objective basis for the diagnosis and the judgment of healing efficacy of CSG treated by traditional Chinese medicine.

The establishment of effective animal models is crucial for disease research.Dietary induction is a common method to establish animal models of non-alcoholic fatty liver disease(NAFLD).The common animal models of diet-induced NAFLD mainly include high fat and sugar,high fat and cholesterol,and choline-deficient diet-induced models.Because of the various nutrients ingested in different modeling method,pathological characteristics of the liver,such as fatty deformation,inflammation,and fibrosis,are different.Additionally,animal models vary in terms of disease progression,disease severity,and applicable studies.This study analyzed and compared the common animal models of NAFLD induced by various diets in terms of modeling method,modeling time,pathological characteristics,applicable research,and related advantages and disadvantages to provide a reference for NAFLD researchers to select animal models.

It is generally accepted that both Parkinson's disease (PD) and cerebral small vessel disease (CSVD) are chronic diseases of central nervous system which are very common in middle aged and elderly people.Although their clinical manifestations are different,a large number of studies have shown that there is similar pathogenesis in many respects,including age,genetic factors,environmental factors,oxidative stress and inflammatory reaction.Furthermore,inflammation is one of the important pathogenesis of PD and it aggravates the damage of dopamine neurons;inflammatory mechanisms are involved in the pathogenesis of CSVD,which may be involved in the pathogenesis of PD due to the immune responses that produce or accelerate the damage of dopaminergic neurons.This article will describe the relationship between PD and CSVD from the perspective of inflammation.

Visual impairment is one of the most common non-motor symptoms of Parkinson's disease (PD). Retinal changes may be the structural basis of visual impairment. This article reviews the visual impairment and retina morphology of PD patients, functional examination and possible mechanism to provide ideas for the study of mechanism of visual impairment in patients with PD.

Objective To analyze the effect of comprehensive nursing interventions in acute cerebral infarction thrombolytic therapy, and to explore the nursing measures of acute cerebral infarction.Methods A total of 300 patients with acute cerebral infarction treated with thrombolytic therapy were enrolled in this study.According to the different nursing methods, the patients were divided into observation group and control group.The patients in the control group were treated with routine nursing care and the observation group was treated with psychological care, health education, rehabilitation nursing and discharge guidance on the basis of the control group.The clinical curative effect, serum IL-6 levels, daily living ability, and nursing satisfaction were compared.Results The response rate of the observation group was higher than that of the control group (P<0.05).The scores of daily living ability were higher, the scores of serum IL-6 were significantly lower and satisfaction was higher in the observation group than that in the control group (P<0.05).Conclusion Comprehensive nursing intervention can improve the therapeutic effect of patients, promote the daily living ability and improve the satisfaction of nursing, reduce the level of serum IL-6, so it is worth learning.

Objective To analyze the effect of comprehensive nursing interventions in acute cerebral infarction thrombolytic therapy, and to explore the nursing measures of acute cerebral infarction.Methods A total of 300 patients with acute cerebral infarction treated with thrombolytic therapy were enrolled in this study.According to the different nursing methods, the patients were divided into observation group and control group.The patients in the control group were treated with routine nursing care and the observation group was treated with psychological care, health education, rehabilitation nursing and discharge guidance on the basis of the control group.The clinical curative effect, serum IL-6 levels, daily living ability, and nursing satisfaction were compared.Results The response rate of the observation group was higher than that of the control group (P<0.05).The scores of daily living ability were higher, the scores of serum IL-6 were significantly lower and satisfaction was higher in the observation group than that in the control group (P<0.05).Conclusion Comprehensive nursing intervention can improve the therapeutic effect of patients, promote the daily living ability and improve the satisfaction of nursing, reduce the level of serum IL-6, so it is worth learning.

Primary coenzyme Q10 deficiency is an autosomal recessive disorder caused by mutations in the genes encoding key enzymes in the biosynthesis of CoQ10.This paper reports for the first time a primary CoQ10 deficiency caused by a novel heterozygous mutation of coenzyme Q8A(COQ8A)gene.The patient was a 26-year-old male with slow-onset ataxia,movement intolerance,tremor and epilepsy as the main manifestations.Primary coenzyme Q10 deficiency was diagnosed and whole exome gene sequencing revealed compound heterozygous mutations in the COQ8A gene[NM_020247.5:exon8:c.1009G>A(p.A337T)and NM_020247.5:exon8:c.1078delC(p.Q360Sfs*20)].The symptoms improved after treatment with supplementation of CoQ10.This case report suggests that the possibility treatable primary CoQ10 deficiency should be considered when patients present with ataxia,dyskinesia,especially with epilepsy or cognitive impairment.