Objective To explore the clinical effect of aritificial total knee arthroplasty ( TKA) in the treat-ment of knee osteoarthritis ( KOA) patients with varus deformity .Methods 41 KOA patients ( 52 knees ) with varus deformity were treated by TKA ,and the clinical effect was observed .Results After treatment ,the knee varus angle , flexion contracture degrees,HSS score were (174.50 ±2.10)°,(0.30 ±0.16)°,(87.60 ±4.70)points,respective-ly,which were significantly improved compared with [(19.80 ±1.30)°,(21.20 ±0.90)°,(37.30 ±3.50)points] before treatment (t=451.68,165.99,69.05,51.57,all P<0.05).Conclusion TKA has an ideal efficacy for knee flexion deformity ,accurately cut bone and soft tissue balance correction is the key in turned knee flexion contracture deformity surgery .