Objective To evaluate iodine nutrition status and vitamin D level in hyperthyroidism patients and explore their impacts on the pathogenesis of hyperthyroidism.Methods Totally 116 inpatients of hyperthyroidism were tested for serum thyroid function,urine iodine and serum 25-OH-D.Median and component ratio of urine iodine and 25-OH-D were used to evaluate nutrition status.Results The median of urine iodine was 224.9 μg/L,while the component ratio of iodine excessive-intake was 59.48％ (12.93％ in excessive group and 46.55％ in sufficient group).The median of vitamin D was 7.19 ng/ml while as deficiency group accounted for 93.2％ in hyperthyroidism patients.Conclusions Attention should be paid to excessive intake iodine in hyperthyroidism patients.Vitamin D supplementation is important for treating hyperthyroidism and maintaining the health of skeleton and muscle.