1.Effect of Electroacupuncture on Different Sites on Detrusor Pressure of Detrusor Areflexia Neurogenic Bladder after Spinal Cord Injury
Yingchun SUN ; Jianjun LI ; Xiankuan CHENG ; Zhigang CHEN ; Qiang ZHANG ; Shan JING ; Jiechen ZHOU
Chinese Journal of Rehabilitation Theory and Practice 2014;(8):734-737
(SCI) to find optimal locations for electroacupuncture. Methods 108 incomplete SCI patients were selected following International Standards for Neurological Classification of Spinal Cord Injury (ASIA 2006) and randomly assigned to urethral catheterization group, control group, and experiment group with 36 cases in each group. The urethral catheterization group was only given intermittent catheterization, the control group was given electroacupuncture of Baliao (BL31 to BL34) and Huiyang (BL35) as the main points and intermittent catheterization, and the experiment group was treated with transcranial electrical stimulation of foot motor sensory area and Abdominal Area Six as the main points and intermittent catheterization. They were assessed with voiding diary and urodynamic test before and after treatment. Results There were significant differences among the urethral catheterization group, the control group, and the experiment group in automatic micturition volume, urethral catheter output and residual urine volume after treatment (P<0.05). Detrusor pressure and reflection was significantly different in the control group and the experiment group before and after treatment (P<0.05), but not in the urethral catheterization group (P>0.05). There was significant difference in detrusor pressure and reflection in the urethral catheterization group from both the control group and the experiment group after treatment (P<0.05). Conclusion Electroacupuncture can promote automatic micturition in patients with detrusor areflexia neurogenic bladder after incomplete SCI.
2.Potential therapeutic effects and applications of Eucommiae Folium in secondary hypertension
Mengyuan LI ; Yanchao ZHENG ; Sha DENG ; Tian YU ; Yucong MA ; Jiaming GE ; Jiarong LI ; Xiankuan LI ; Lin MA
Journal of Pharmaceutical Analysis 2022;12(5):711-718
Eucommiae Folium(EF),a traditional Chinese medicine,has been used to treat secondary hypertension,including renal hypertension and salt-sensitive hypertension,as well as hypertension caused by thoracic aortic endothelial dysfunction,a high-fat diet,and oxidized low-density lipoprotein.The antihyperten-sive components of EF are divided into four categories:flavonoids,iridoids,lignans,and phenyl-propanoids,such as chlorogenic acid,geniposide acid and pinoresinol diglucoside.EF regulates the occurrence and development of hypertension by regulating biological processes,such as inhibiting inflammation,regulating the nitric oxide synthase pathway,reducing oxidative stress levels,regulating endothelial vasoactive factors,and lowering blood pressure.However,its molecular antihypertensive mechanisms are still unclear and require further investigation.In this review,by consulting the relevant literature on the antihypertensive effects of EF and using network pharmacology,we summarized the active ingredients and pharmacological mechanisms of EF in the treatment of hypertension to clarify how EF is associated with secondary hypertension,the related components,and underlying mechanisms.The results of the network pharmacology analysis indicated that EF treats hypertension through a multi-component,multi-target and multi-pathway mechanism.In particular,we discussed the role of EF tar-gets in the treatment of hypertension,including epithelial sodium channel,heat shock protein70,rho-associated protein kinase 1,catalase,and superoxide dismutase.The relevant signal transduction path-ways,the ras homolog family member A(RhoA)/Rho-associated protein kinase(ROCK)and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase/eNOS/NO/Ca2+pathways,are also discussed.
3.Textual Research on Tibetan Medicinal Herb Lamiophlomis Herba
Jiaming GE ; Angtan SUONAN ; Shengfu KANG ; Sihan GONG ; Tianbao SONG ; Ying ZHAO ; Weisan CHEN ; Xiankuan LI
Chinese Journal of Experimental Traditional Medical Formulae 2023;29(14):164-172
Lamiophlomis Herba, one of the medicinal herbs commonly used by the Tibetan ethnic minority, has the effect of activating blood, stopping bleeding, dispelling wind, and relieving pain and is frequently used to treat trauma, traumatic bleeding, rheumatic arthralgia, and dampness and dampness-heat. By a review of ancient Tibetan medicine classics, materia medica classics, and modern literature, this paper systematically analyzed the name, nature, taste, original plant, medicinal part, harvest, processing, efficacy, and indications of Lamiophlomis Herba. The textual research showed that Lamiophlomis Herba was first recorded in the Somaratsa (《月王药诊》) in the middle of the eighth century. This medicinal herb was mainly recorded with a plain and warm nature and a sweet, bitter, and astringent taste. The herb was recorded as non-toxic in other books except the Tibetan Medicinal Plants in Gannan of Qinghai-Tibet Plateau (《青藏高原甘南藏药植物志》). In the books of the past dynasties, the aboveground part of Lomiophlomis rotatd was used as medicine. In addition, there were also records of using the whole herbs of Ajuga ovalifolia, A. ovalifolia var. calantha, and Oreosolen wattii as the medicine. In ancient times, the herb was mainly harvested before Frost's Descent in the 8th-9th months of the lunar calendar, while it was mainly harvested during the flowering-fruiting stage in autumn in modern times. Due to the decreased reserve of Lamiophlomis Herba, the medicinal part evolved from whole herb or fresh leaves to the aboveground part. According to the ancient and modern records, this herb mainly has the functions of nourishing bone and marrow, eliminating dampness and dampness-heat, stopping bleeding, and relieving pain. In ancient times, it was used for treating parasitic diseases, menostaxis, spermatorrhea, diarrhea, and nourishing the body. This paper aims to provide a basis for further development and study of Lamiophlomis Herba through the textual research.