1.Comparison of proximal femoral intramedullary nail and hip arthroplasty in the treatment of intertrochanteric fracture
Chinese Journal of Tissue Engineering Research 2015;(13):1979-1983
BACKGROUND:Intertrochanteric fracture is often found in osteoporotic elderly patients, the commonly used treatment includes intramedul ary and extramedul ary fixations, and joint replacement. OBJECTIVE:To compare the clinical effect of proximal femoral intramedul ary nail and hip arthroplasty in the treatment of intertrochanteric fracture. METHODS:198 patients of intertrochanteric fracture recruited from Heze Municipal Hospital from August 2009 to August 2013, were divided into two groups. Each group had 99 patients, receiving proximal femoral intramedul ary nail and hip arthroplasty, respectively. RESULTS AND CONCLUSION:The average operation time, intraoperative blood loss and hospital stays in the proximal femoral intramedul ary nail group were significantly shorter, while the healing time of fracture was significantly longer than that in the hip arthroplasty group. At postoperative 1 year, there was no statistical difference in the Harris score, the excel ent and good rate of hip function, and the overal incidence of complications between the two groups. Experimental findings indicate that, both proximal femoral intramedul ary nail and hip arthroplasty are biocompatible and effective in the treatment of intertrochanteric fracture, and each technique has their advantages and disadvantages, we should choose the proper technique according to the patient’s condition.
2.Clinical analysis of Frey syndrome incidence of 202 cases after parotidectomy
Journal of Practical Stomatology 2016;32(1):131-132
Clinical data of Frey syndrome of 202 cases after excision of parotid gland were analysed.Frey syndrom was observe in 22 out off 1 49 cases(1 4.7%)received block processing of sympathetic (SN)and parasympathetic (PN)nerve anastomosis and in 1 4 out off 53 (26.4%)without the block processing(P≤0.01 ).The block processing of SN and PN anastomosis is effective for the prevention of postop-erative Frey syndrome after parotidectomy.
4.X-ray Diagnosis of Hydatid Cysts of the Breast(A Report of 7 Cases and A Review of the Literature)
Li ZENG ; Xianjun LI ; Chunmei YUAN
Journal of Practical Radiology 2001;0(07):-
Objective To improve understanding of molybdenum target mammographic findings of hydatid cyst of the breast.Methods The data of mammographic findings of 7 cases with hydatid cysts confirmed by operation and pathology were collected and analyzed retrospectively. The related literatures were reviewed.Results Among 7 cases of hydatial cysts, multiple cyst in one, singular cyst in 6, one of them was rupture caused by trauma. Mammography showed a circluar or elliptical dense shadow, the density was homogeneous with well defined margen, measured 4~8 cm in maximum diameter, 3 cases appeared typical shell-like calcification.Conclusion In combination with clinical and endemical data, molybdenum target mammography can be used in diagnosing hydatid cyst of the breast.
5.The research progress of volume-sensitive Cl- channel in tumor
Xianjun MIN ; Jun WANG ; Hui LI
Cancer Research and Clinic 2010;22(11):787-789
Cell swelling activates or upregulates a number of anion channels. Of the volume-activated or-regulated anion channels, the volume-sensitive outwardly rectifying anion channel (VSOR) is most prominently activated and ubiquitously expressed. Volume regulated chloride channels play significant roles in a variety of physiological processes including volume regulation, proliferation, differentiation, migration,apoptosis and resistance of tumor cells. Molecular identification and activation mechanisms of VSOR are poorly understood. Many signaling molecules have been shown to regulate VSOR activity in research, playing permissive or modulatory roles. Therefore, VSOR may be a new anticancer target by identifying its signaling molecules and activation mechanisms.
6.Effects of Shuxuetong Injection on expressions of cell apoptosis and TLR 4 around ischemic area after focal cerebral infarction in rats
Yihua ZHONG ; Guangqin LI ; Xianjun TANG
Chongqing Medicine 2013;(25):3011-3014
Objective To investigate the effects of Shuxuetong Injection (SXT ) on expressions of cell apoptosis and TLR4 a-round ischemic area after focal cerebral infarction in rats and to discuss its neuroprotective mechanism on ischemia-induced brain in-jury .Methods The SD rats were subjected to establish the model of middle cerebral artery occlusion (MCAO)by nylon monofila-ment suture ,then were randomly divided into the sham-operated group ,the model group and the SXT treatment group ;the cell ap-optosis and the expressions of TLR4 mRNA and protein around ischemic area at 12 ,24 ,48 ,72 h after cerebral ischemia were detec-ted respectively by TUNEL test mediated with DNA ,RT-PCR and immunohistochemistry .Results In the model group ,the number of TUNEL positive cells ,the expressions of TLR4 mRNA and protein were gradually increased at 12 h ,reached the peak at 24 h , then decreased and were still higher than those in the sham-operated group(P<0 .01);in the SXT treatment group ,these expres-sions after 24 h were lower than those in the model group (P<0 .05)and declined as the treatment time increase(P<0 .05) .Conclu-sion In subacute stage of cerebral ischemia injury ,apoptosis is related with the expression of TLR4 ,SXT may inhibit apoptosis , down-regulate the expression of TLR4 around ischemic area ,this may be one of the mechanisms of neuroprotection .
7.Analysis of Medicine Utilization Variation of Inpatient Participated Insurance after Implementing the 2009 Edition of National Reimbursement Drug List
Jie ZHANG ; Xianjun XIONG ; Jinghu LI
Chinese Health Economics 2014;(3):39-41
Objective:To understand the impact of adjusting national drug reimbursement list(NDRL) have on the benefits of patient covered by Basic Health Insurance ( BHI ) , medical insurance fund expenditure and specific drug marketing . Methods: Based on the survey data of medical service utilization situation of national inpatients participated BHI, to summarize and analyze the change of drug usage from 2009 to 2011. Results: In 2011, the drug expense of the national inpatient covered by BHI is approximately 132.7 billion yuan, increased by 37% compared to that of 2009; among which, the expense of entry drug accounts for about 76% out of the total drug use. In 2011, new increased expense on drug use is 13.5 billion, which increased to 98% compared to that of 2009. Conclusion:Adjustment of NDRL had little effect on total drug expenses increasing, but lead changes of the drug expense structure; and expense on some new entry drugs increased obviously. The focus of future adjustment of NRDL could gradually transfer from guaranteeing on basic medicine use to the promotion on clinical rational drug use.
8.Therapeutic effect observation of Neurotropin in the treatment of senile postherpetic neuralgia
Linping LIANG ; Meiye LI ; Xianjun ZHANG
Journal of Clinical Neurology 1993;0(03):-
Objective To discuss the efficacy of Neurotropin in the treatment of senile postherpes neuralgia.Methods 58 senile patients with postherpes neuralgia were randomly divided into Neurotropin group and Carbamazepine group. Before and after treatment, symptoms and signs of neuropathy including pain and numbness were evaluated by vision ambiguity scales(VAS). The side effects of drugs were also observed.Results 2,4,6 weeks of post-therapy,the VAS of Neurotropin group was decreased obviously than that of pretherapy (all P
9.Alteration in Potassium Channel in Ventricular Myocytes in Diabetic Rats
Xun LI ; Xianjun YANG ; Wenping JIANG
Chinese Journal of Hypertension 2006;0(08):-
Objective To investigate the change in potassium channel in ventricular myocytes in vitro derived from diabetic rats and the effect of insulin and dichloroaectic acid(DCA). Methods The diabetic rat model was established by injection of streptozocin(STZ) peritoneally using male Sprague-Dawley rats with body weight 150-200 gram. Ventricular myocytes were isolated by enzymatic method and the whole-cell patch clamp technique was used to record the potassiumion currents. Results The I to density of ventricular myocytes in diabetic rats was significantly decreased compared with control rats[at+60 mV, 15.90?1.19 pA/pF (n=25) vs 28.55?0.97 pA/pF (n=12), P
10.Expression and significance of estrogen receptor subsets ER?,ER? and ki-67 in tissues of different thyroid diseases
Dongling JIN ; Lianxiang LI ; Xianjun LIU
Medical Journal of Chinese People's Liberation Army 2001;0(09):-
Objective To investigate the expression and clinical significance of the estrogen receptor(ER) subsets ER?,ER? and Ki-67 in tissues of different thyroid diseases.Methods The pathological data of 93 patients with thyroid diseases were collected from Jun.2003 to Jun.2007,including thyroid carcinoma(56 cases),thyroid follicular adenoma(13 cases),nodular goiter(14 cases) and normal thyroid tissue(10 cases).S-P immunohistochemistry was performed to determine the expressions of ER?,ER? and Ki-67 in the thyroid tissues.Results ER? and ER? were expressed in the plasma and nuclei of thyroid epithelial cells,and ER? was also expressed in the stroma.The positive rates of ER? expression in cases with thyroid carcinoma,thyroid follicular adenoma,nodular goiter and normal thyroid tissue was 87.5%,69.2%,42.9% and 30.0%,respectively,with significant difference between carcinoma and goiter or normal thyroid tissue(P0.05).Conclusion ER? and ER? may play an aggravating effect on cell proliferation in the disease course of the thyroid carcinoma.The expressions of ER? and Ki-67 are related to invasion and metastasis of thyroid carcinoma.