Objective To study and analyze the detection significance of platelet indexes and pancreatic blood flow parameters in the patients with severe acute pancreatitis(SAP).Methods Sixty-one patients with SAP in our hospital from June 2014 to June 2016 were selected as the group A,contemporaneous 61 patients with mild acute pancreatitis were selected as group B and 61 persons undergoing the healthy physical examination were selected as the group C.Then the platelet indexes and pancreatic blood flow parameters were detected and compared among 3 groups,and at the same time the platelet indexes and pancreatic blood flow parameters in the group A were compared among different stages of disease course.Results MPV,PDW and platelet activation indexes in the group A were all significantly higher than those in the group B and C,while PCT was lower than that in the group B and group C,the pancreatic head and pancreatic tail blood flow parameters were all worse than those in the group B and C,moreover the pancreatic head and pancreatic tail blood flow parameters in the group B were all worse than those in the group C,and the platelet indexes and pancreatic blood flow parameters in the group A all had significant differences among different stages of disease course (P<0.05),the differences in these indexes were statistically significant.Conclusion The detection significance of platelet indexes and pancreatic blood flow parameters in the patients with SAP is higher,and also has a certain value for the disease course stages in the patients with SAP,so their monitoring has higher value.