Objective To study and analyze the detection significance of platelet indexes and pancreatic blood flow parameters in the patients with severe acute pancreatitis(SAP).Methods Sixty-one patients with SAP in our hospital from June 2014 to June 2016 were selected as the group A,contemporaneous 61 patients with mild acute pancreatitis were selected as group B and 61 persons undergoing the healthy physical examination were selected as the group C.Then the platelet indexes and pancreatic blood flow parameters were detected and compared among 3 groups,and at the same time the platelet indexes and pancreatic blood flow parameters in the group A were compared among different stages of disease course.Results MPV,PDW and platelet activation indexes in the group A were all significantly higher than those in the group B and C,while PCT was lower than that in the group B and group C,the pancreatic head and pancreatic tail blood flow parameters were all worse than those in the group B and C,moreover the pancreatic head and pancreatic tail blood flow parameters in the group B were all worse than those in the group C,and the platelet indexes and pancreatic blood flow parameters in the group A all had significant differences among different stages of disease course (P<0.05),the differences in these indexes were statistically significant.Conclusion The detection significance of platelet indexes and pancreatic blood flow parameters in the patients with SAP is higher,and also has a certain value for the disease course stages in the patients with SAP,so their monitoring has higher value.

Objective To investigate the clinical features of IgG4 related autoimmune pancreatitis (AIP). Methods Clinical data of 12 patients pathologically diagnosed as IgG4 related AIP in Department of Hepatopancreatobiliary Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University from January 2003 to December 2012 were retrospectively analyzed. The informed consents of all patients were obtained and the ethical committee approval was received. All the patients were males with a mean age of (54±13) years old. All were misdiagnosed as pancreatic head carcinoma and received pancreatoduodenectomy. Data of the clinical manifestations, laboratory, imaging and pathological examinations were collected. The patients were followed up after operations, the treatment and outcome were studied. Results The clinical manifestations of the 12 patients were abdominal pain (n=7), jaundice(n=7), emaciation(n=6) and no obvious symptom (n=1). Three cases were combined with diabetes, 1 case with chronic sialadenitis of submandibular gland. The patient's blood and urine amylase were normal. Blood gamma-glutamyl transpeptidase (GGT) increase was observed in 12 cases. Mild increase of carbohydrate antigen 19-9 (CA19-9) was observed in 9 cases. Cancer antigen (CA) 125 increase was observed in 3 cases, and carcinoembryonic antigen (CEA) increase in 2 cases. Through contrast-enhanced CT, partial pancreatic head enlargement was observed in 11 cases, in which 3 cases were observed combining with mild expansion of pancreatic duct. Through magnetic resonance imaging (MRI), sausage-like change of pancreas body was observed in 4 cases, peripancreatic sheath-like change in 5 cases. Through magnetic resonance cholangiopancreatography (MRCP), stenoses in the pancreatic duct of pancreatic head segment and distal common bile duct were observed including 4 cases of mild expansion in the distal pancreatic duct. Local invasion was not observed by imaging examinations. Lymphoplasmacytic sclerosing pancreatitis was determined by pathological examination. Positive expression of IgG4 was observed by immunohistochemistry. Twelve cases suffered from discontinuous abdominal pain after operations, in which 7 cases needed acesodyne. One case relieved after using prednisone. Conclusions Clinical manifestations of IgG4 related AIP are similar to pancreatic carcinoma and can be misdiagnosed as pancreatic carcinoma easily. The main clinical features are mild increase of blood CA19-9. Partial pancreatic head enlargement, pancreas body sausage-like change, peripancreatic sheath-like change, and no local invasion are observed by imaging examinations. Lymphoplasmacytic sclerosing pancreatitis is determined by pathological examination. Positive expression of IgG4 is observed by immunohistochemistry. Adrenocortical hormone treatment is effective.