Objective? To explore the effects of multidisciplinary collaboration on quality of life in elderly cardiovascular disease patients with diabetes mellitus. Methods? By convenience sampling, from Januaryto May 2018, we selected 50 elderly cardiovascular disease patients with DM of Cardiovascular Department at Zhejiang Hospital in experimental group with multidisciplinary collaboration nursing. From June to December 2018, we selected 50 patients in control group with routine nursing.We compared the scores of Generic Quality of Life Inventory-74 (GQOLI-74) and nursing satisfaction of patients between two groups. Results? After intervention, the scores of GQOLI-74 of patients in experimental group were higher than those in control group with statistical differences (P＜ 0.05). After intervention, satisfaction of patients in experimental group was 96.0% (48/50) was higher than that 74.0% (37/50) in control group with a statistical difference (P＜0.05). Conclusions Multidisciplinary collaboration can effectively improve quality of life and nursing satisfaction among elderly cardiovascular disease patients with diabetes mellitus which is worth to be implemented in clinical practice.