Objective To observe the clinical effect of Yiqi Huatan prescription in the treatment of patients with systolic hypertension ( qi -deficiency and phlegm type ) .Methods 120 patients with systolic hypertension (qi-deficiency and phlegm type) were selected,and they were randomly divided into observation group and control groupaccording to randomized,double-blind method,with 60 cases in each group.The control group received conventional western medicine treatment , the observation group was given compound Qima capsule combined with conventional western medicine .After treatment , the treatment effect was evaluated , and the levels of inflammatory factors were observed.Results The total effective rate between the two groups had no statistically significant difference (χ2 =0.565,P>0.05).The systolic blood pressure and diastolic blood pressure in the observation group after treatment were (129.77 ±5.56)mmHg,(79.48 ±4.83)mmHg,respectively,which were significantly lower than before treat-ment [(171.15 ±18.81)mmHg,(94.42 ±8.71)mmHg] and those in the control group after treatment [(135.48 ± 7.81)mmHg,(83.81 ±5.29)mmHg] ( t=6.223,8.936,12.365,8.114,all P<0.05).After treatment,the levels of CRP,IL-6,TNF -in the observation group were (3.07 ±0.28) mg/L,(0.08 ±0.04) ng/L and (5.08 ± 1.03)ng/L,respectively,which were significantly lower than before treatment [(5.24 ±0.49) mg/L,(0.22 ± 0.05)ng/L,(9.42 ±2.49)ng/L,t=6.248,9.246,8.335,5.234,5.012,6.214,all P<0.05] and those in the control group after treatment [(4.18 ±0.19)mg/L,(0.12 ±0.05)ng/L,(6.11 ±2.07)ng/L,t=9.246,5.112, 5.012,all P<0.05].Conclusion Yiqi Huatan prescription in the treatment of systolic hypertension of qi -deficiency and phlegm type can achieve good therapeutic effect , the mechanism may be related with reducing inflammatory factors.