Objective To investigate the clinical features and treatment principles of inflammatory myofibroblastic tumor of the urinary bladder (IMTUB).Methods From April 2013 to October 2016,6 cases of IMTUB patients were analyzed retrospectively.All cases were presented with gross hematuria.4 cases underwent ultrasonography,of which 3 cases showed solid mass in bladder,1 case showed inflammatory change.6 cases underwent CT examination,3 cases with bladder cancer,1 case with bladder sarcoma,1 case with malignant transformation of adenoma,1 case with rich blood supply.No lymph node metastasis.Bladder occupying lesions were considered in 2 cases of MRI examination.5 cases of cystoscopy showed bladder solid mass.In 6 cases involved,2 patients received partial cystectomy,2 patients underwent transurethral resection of bladder tumor,1 patient underwent radical resection of urachal carcinoma and the other one was treated with chemotherapy.Results Immunohistochemical staining was positive in ALK (100.0％) 、Vimentin(100.0％) 、CK(100.0％) 、SMA (83.3％) 、EMA(66.7％) and Ki-67 (5％-30％),negative in S-100 and Desmin.Final pathological diagnosis was IMTUB.So far,neither recurrence nor metastasis has been detected for 6 ～ 42 months in 5 cases and the other one lost to follow-up.Conclusions IMTUB is a kind of rare benign tumor of bladder.The golden standard of diagnosis is pathological diagnosis.Surgical resection is the first choice for treatment.Recurrence and metastasis are after the surgery treatment.All patients should be followed up closely.

Objective:To explore the correlation between liver shear wave velocity(Vs) measured with acoustic radiation force impulse (ARFI) imaging technique and serum fibrosis indexes and its application in the diagnosis of liver cirrhosis and Child‐Pugh scoring for cirrhosis .Methods:The liver Vs value measured with ARFI technique of 150 patients with liver cirrhosis (ob‐servation group) and 50 healthy volunteers(control group) who visited Shanghai Dahua Hospital in Xuhui District during Jul 2013 and Jul 2014 were analyzed retrospectively .The 150 patients with liver cirrhosis were set as observation group and further divided into Class A(n=50) ,Class B(n=50) and Class C(n=50) according to Child‐Pugh scoring system .The 50 healthy vol‐unteers were set as control group .Serum fibrosis indexes testing ,including hyaluronic acid(HA) and laminin(LN) ,procollagenⅢ(PCⅢ) and collagenⅣ (Ⅳ‐C) ,were performed in all subjects .Differences between the observation group and the control group regarding indexes were compared by using independent sample t‐test .Pearson correlation analysis and receiver operator characteristic(ROC)curve analysis were conducted between Vs and four serum indexes in the observation group .Results:The values of Vs ,HA ,LN ,PCⅢ and Ⅳ‐C in the observation group were higher than those in the control group(P<0 .01) .Fur‐thermore ,the Vs value in the observation group demonstrated positive correlation with HA ,LN ,PCⅢ and Ⅳ‐C ,and the corre‐lation coefficients were 0 .672 ,0 .672 ,0 .765 and 0 .568 ,respectively(P<0 .01) .Area under ROC curve of the values of Vs and serum inedxes were 0 .85 0 .65 ,0 .71 ,0 .63 ,0 .73 in Class A ,0 .93 ,0 .83 ,0 .86 ,0 .84 ,0 .80 in Class B ,and 0 .99 ,0 .94 ,0 .85 , 0 .95 ,0 .94 in Class C ,respectively .Conclusions:Vs ,a non‐invasive marker for liver elasticity and stiffness ,is significantly correlated with serum fibrosis indexes .Its sensitivity and specificity are superior to those of four serum fibrosis indexes .It could provide qualitative analysis for evaluating the severity of liver cirrhosis ,so as to offer valuable evidence for further clinical treat‐ment .

Background::Transplant renal artery stenosis (TRAS) is a vascular complication after kidney transplantation associated with poor outcomes. This study aimed to analyze the efficacy and safety of low-dose aspirin for preventing TRAS.Methods::After kidney transplantation, patients were enrolled from January 2018 to December 2020 in Henan Provincial People’s Hospital. A total of 351 enrolled recipients were randomized to an aspirin group with low-dose intake of aspirin in addition to standard treatment ( n = 178), or a control group with only standard treatment ( n = 173). The patients was initially diagnosed as TRAS (id-TRAS) by Doppler ultrasound, and confirmed cases were diagnosed by DSA (c-TRAS). Results::In the aspirin and control groups, 15.7% (28/178) and 22.0% (38/173) of the recipients developed id-TRAS, respectively, with no statistical difference. However, for c-TRAS, the difference of incidence and cumulative incidence was statistically significant. The incidence of c-TRAS was lower in the aspirin group compared with the control group (2.8% [5/178] vs. 11.6% [20/173], P = 0.001). Kaplan–Meier estimates and Cox regression model identified the cumulative incidence and hazard ratio (HR) of TRAS over time in two groups, showing that recipients treated with aspirin had a significantly lower risk of c-TRAS than those who were not treated (log-rank P = 0.001, HR = 0.23, 95% confidence interval [CI]: 0.09–0.62). The levels of platelet aggregation rate ( P < 0.001), cholesterol ( P = 0.028), and low-density lipoprotein cholesterol ( P = 0.003) in the aspirin group were decreased compared with the control group in the third-month post-transplantation. For the incidence of adverse events, there was no statistical difference. Conclusion::Clinical application of low-dose aspirin after renal transplant could prevent the development of TRAS with no significant increase in adverse effects.Trial Registration::Clinicaltrials.gov, NCT04260828.