1.Telpegfilgrastim for chemotherapy-induced neutropenia in breast cancer: A multicenter, randomized, phase 3 study.
Yuankai SHI ; Qingyuan ZHANG ; Junsheng WANG ; Zhong OUYANG ; Tienan YI ; Jiazhuan MEI ; Xinshuai WANG ; Zhidong PEI ; Tao SUN ; Junheng BAI ; Shundong CANG ; Yarong LI ; Guohong FU ; Tianjiang MA ; Huaqiu SHI ; Jinping LIU ; Xiaojia WANG ; Hongrui NIU ; Yanzhen GUO ; Shengyu ZHOU ; Li SUN
Chinese Medical Journal 2025;138(4):496-498
2.Analysis of the predictive value of acetabular prosthesis selection and osteotomy accuracy in adult devel-opmental dysplasia of the hip total hip arthroplasty based on MSCT 3D scanning + reconstruction
Xiaorong CUI ; Lihua LAN ; Xiangyang LI ; Zhifeng ZHONG
The Journal of Practical Medicine 2024;40(9):1309-1313
Objective To explore the effect of MSCT 3D scanning and reconstruction on developmental dysplasia of the hip(DDH)in adult patients with total hip arthroplasty,The predictive value of acetabular prosthesis selection and osteotomy accuracy in THA.Methods Selection in our hospital between February 2021 and February 2023 were 60 adult DDH patients underwent total hip replacement,which USES routine preoperative planning as a control group of 30 patients,and using MSCT + reconstruction of 3 d scanning technology as observation group of 30 patients,planning after the completion of the planning of the surgical operation and implant placement,Relevant information was collected before and after the operation of the two groups.Operation time,intraoperative blood loss,intraoperative fluoroscopy time,acetabular prosthesis selection and matching rate,femur split fracture rate,pelvis and acetabular reduction quality,Majeed score and Harris hip function score were compared between the two groups.The osteotomy distance and sharp shoulder distance of the two groups were compared before planning and in actual conditions,and the correlation between MSCT 3D scanning and reconstruction technology and the accuracy of acetabular prosthesis selection was evaluated.Results Results analysis showed that MSCT 3D scanning+reconstruc-tion technology used in preoperative evaluation of patients in the observation group was correlated with the accuracy of acetabular prosthesis selection(P<0.05),and the absolute errors of osteotomy distance and sharp shoulder distance of patients in the observation group were smaller than the actual situation before planning(P<0.05).In addition,compared with the control group,the operative time,intraoperative blood loss,intraoperative fluoroscopy time and incidence of femoral split fracture in the observation group were significantly lower,and the matching rate of acetabular prosthesis selection,the Majeed scores and Harris scores were significantly higher in the following 3 months were significantly higher(P<0.05).The reduction quality of pelvis and acetabulum was not statistically significant between the two groups(P>0.05).Conclusion Msct-based 3D scanning + reconstruction has a high predictive value for the selection of acetabular prosthesis and the accuracy of osteotomy in adult DDH total hip replacement,and the use of this technology for preoperative planning has a significant optimization effect on the actual treatment effect and patient recovery.
3.Evidence-based guideline for clinical diagnosis and treatment of acute combination fractures of the atlas and axis in adults (version 2023)
Yukun DU ; Dageng HUANG ; Wei TIAN ; Dingjun HAO ; Yongming XI ; Baorong HE ; Bohua CHEN ; Tongwei CHU ; Jian DONG ; Jun DONG ; Haoyu FENG ; Shunwu FAN ; Shiqing FENG ; Yanzheng GAO ; Zhong GUAN ; Yong HAI ; Lijun HE ; Yuan HE ; Dianming JIANG ; Jianyuan JIANG ; Weiqing KONG ; Bin LIN ; Bin LIU ; Baoge LIU ; Chunde LI ; Fang LI ; Feng LI ; Guohua LYU ; Li LI ; Qi LIAO ; Weishi LI ; Xiaoguang LIU ; Yong LIU ; Zhongjun LIU ; Shibao LU ; Fei LUO ; Jianyi LI ; Yong QIU ; Limin RONG ; Yong SHEN ; Huiyong SHEN ; Jun SHU ; Yueming SONG ; Tiansheng SUN ; Jiang SHAO ; Jiwei TIAN ; Yan WANG ; Zhe WANG ; Zheng WANG ; Xiangyang WANG ; Hong XIA ; Jinglong YAN ; Liang YAN ; Wen YUAN ; Jie ZHAO ; Jianguo ZHANG ; Yue ZHU ; Xuhui ZHOU ; Mingwei ZHAO
Chinese Journal of Trauma 2023;39(4):299-308
The acute combination fractures of the atlas and axis in adults have a higher rate of neurological injury and early death compared with atlas or axial fractures alone. Currently, the diagnosis and treatment choices of acute combination fractures of the atlas and axis in adults are controversial because of the lack of standards for implementation. Non-operative treatments have a high incidence of bone nonunion and complications, while surgeries may easily lead to the injury of the vertebral artery, spinal cord and nerve root. At present, there are no evidence-based Chinese guidelines for the diagnosis and treatment of acute combination fractures of the atlas and axis in adults. To provide orthopedic surgeons with the most up-to-date and effective information in treating acute combination fractures of the atlas and axis in adults, the Spinal Trauma Group of Orthopedic Branch of Chinese Medical Doctor Association organized experts in the field of spinal trauma to develop the Evidence-based guideline for clinical diagnosis and treatment of acute combination fractures of the atlas and axis in adults ( version 2023) by referring to the "Management of acute combination fractures of the atlas and axis in adults" published by American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) in 2013 and the relevant Chinese and English literatures. Ten recommendations were made concerning the radiological diagnosis, stability judgment, treatment rules, treatment options and complications based on medical evidence, aiming to provide a reference for the diagnosis and treatment of acute combination fractures of the atlas and axis in adults.
4.Relationship between gender role attitudes and depression among adolescents
ZHANG Jiashuai, ZUO Xiayun, YU Chunyan, LIAN Qiguo, ZHONG Xiangyang, TU Xiaowen, LOU Chaohua
Chinese Journal of School Health 2022;43(2):181-184
Objective:
To explore the relationship between gender role attitudes (GRA) and adolescent depression to provide evidence for the promotion of mental health among adolescents.
Methods:
A total of 1 549 students from grades 6 to 8 in three public middle schools in Jing an District of Shanghai were selected by stratified cluster sampling. The baseline and follow up surveys were conducted by anonymous electronic questionnaire on mobile tablets from November to December in 2017 and 2018, respectively. The GRA Scale and the Depression Scale were used to collect subjects attitudes towards traditional role assignment and power inequality between men and woman and depression in family and sexual relationships. The multivariate Generalized Estimating Equations (GEE) model was adopted to examine the relationship between GRA and depression.
Results:
The mean score of the GRA Scale was (2.52±0.83) and (2.29±0.86), while the score of Depression Scale was (15.92±5.08) and (16.48±5.29), in the baseline and follow up survey, respectively ( P <0.05). After controlling the covariates of age, bullied experience, body image, social cohesion, etc., the multivariate GEE model indicated traditional GRA was significantly associated with a higher risk of depression among both boys and girls ( β boys =0.38, β girls =0.41, P <0.05).
Conclusion
Traditional GRA may increase the risk of depression in adolescents, suggesting that cultivating a positive and equal GRA among this population group may help to prevent depression.
5.Influence of impulsivity on adolescents pornography use
YU Chunyan, LIAN Qiguo, ZHONG Xiangyang, ZHANG Jiashuai, TU Xiaowen, LOU Chaohua, ZUO Xiayun
Chinese Journal of School Health 2021;42(3):422-425
Objective:
To explore the influence of impulsive traits of adolescent on pornography use through the analysis of the Global Early Adolescent Study(GEAS) longitudinal survey data collected in Shanghai, and to provide evidence for adolescent sexual health promotion.
Methods:
Totally 1 512 students from grades 6 to 8 in three middle schools in a district of Shanghai were selected for the present study by stratified cluster sampling method. Baseline and two-wave follow-up investigation were conducted between 2017 and 2020. Three waves of pornography use and social demographic information were collected using electronic questionnaire through tablets while impulsivity were tested only once during the follow-up in 2018 using the paper and pencil based Barratt Impulsivity Scale, version11 (BIS-11). General statistical description and panel data statistical description, as well as multilevel mixed effect linear model were used to do the analysis.
Results:
About 32.7% (494) of the adolescents reported the experience of watching pornography in threewave analysis. Boys were more impulsive than girls in the motor subscale (16.33±3.25, 15.66±2.93, t=4.13, P<0.01) while girls were more impulsive than boys in the nonplanning subscale (23.65±5.11, 22.83±5.21, t=-3.03, P<0.01). Mixed effect linear model result showed that impulsivity was correlated with pornography use(β=0.001, P<0.01); higher impulsivity in motor and attention were correlated with more frequent pornography use(P<0.01). Being female, perceived more parental awareness and perceived care from school adults would decrease the use of pornography while spent more than 3 hours on internet would increase the use of pornography (P<0.01).
Conclusion
There are stable correlations between impulsivity and pornography use. It is urgent to equip young adolescents with the necessary ability to distinguish the good from the bad in the mass and internet media world.
6.Association between adverse childhood experiences and adolescent alcohol use
ZHANG Jiashuai, ZUO Xiayun, YU Chunyan, LIAN Qiguo, ZHONG Xiangyang, TU Xiaowen, LOU Chaohua
Chinese Journal of School Health 2021;42(7):1042-1046
Objective:
To explore the association between adverse childhood experiences (ACEs) and adolescent alcohol use and to provide evidence for prevention and intervention.
Methods:
A total of 1 550 students from grades 6 to 8 in three public middle schools in a district of Shanghai were selected by stratified cluster sampling method. The baseline and follow up investigation were conducted by anonymous electronic questionnaire in mobile tablet from November to December in 2017 and 2018, respectively. The latent class analysis (LCA) was applied for the classification of ACEs, while the multivariate generalized estimating Equations (GEE) model was adopted to examine the association between ACEs and adolescent alcohol use.
Results:
The ACEs was divided into 3 classes by LCA: high exposure (8.97%), abuse and neglect (38.97%), low exposure (52.06%). The multivariate GEE model indicates the risk of alcohol drinking among adolescents in high exposure and abuse and neglect classes were significantly higher than their counterparts in low exposure class ( OR=2.65, 95%CI=1.72-4.07; OR=1.50, 95%CI =1.14-1.96, respectively).
Conclusion
The effect of ACEs on alcohol use may vary across different latent classes. Supportive childhood environment may contribute to decrease the risk of adolescent drinking behavior.
7.Heterosexual romantic expectation of early adolescents and its influencing factors
XI Haiyang, ZUO Xiayun, YU Chunyan, LIAN Qiguo, ZHONG Xiangyang, TU Xiaowen, LOU Chaohua
Chinese Journal of School Health 2020;41(1):78-81
Objective:
To explore the heterosexual romantic expectation in early adolescence(10-14 years)and its influencing factors, and to provide a reference for instructing children of early puberty to establish a positive interpersonal relationship(including heterosexual relationship) and improving their healthy development.
Methods:
Stratified cluster sampling method was adopted to recruit students of grade 6-8 in three middle schools of Shanghai during November to December, 2017. Students were surveyed anonymously using Computer Assisted Self-Interview approach via the tablets. The collected data included the information on demographic, families, peers, use of the media, community cohesion and heterosexual romantic expectation. The ttest, Chi-square test, ANOVA and multiple linear regression were used to explore the relationships between potential factors and heterosexual romantic expectation.
Results:
The mean score of heterosexual romantic expectation was 2.55. Score of the boys was higher than that of girls (2.62 vs. 2.47, t=2.65, P<0.05). There was no statistically significant difference between the scores of the ages before 12 years old (10-11: 2.34, 12: 2.28), but a significant increase of the scores along the age after 12 years old(13: 2.69, 14: 3.05). Multiple linear regression suggested that respondents with older age, poorer caregiver-child relationship, higher proportion of friends of the opposite sex, more friends that thought having boyfriends/girlfriends was important, more TV/movie use and lower community cohesion had higher score of heterosexual romantic expectation of early adolescents(P<0.05).
Conclusion
The early adolescents had relative conservative views on the heterosexual romantic relationships of adolescents of their own age while the boys were more permissive than girls. The heterosexual romantic expectation improved significantly after 12 years and may be influenced by factors of family, peers, media and community.
8.Prevalence and influencing factors of colorectal polyps in Lanxi residents
Weifang ZHENG ; Xiaodong HU ; Zihan YIN ; Zhonghua LU ; Shengzhi WU ; Zhong SHEN ; Menghan JIA ; Chen WEI ; Xiangyang ZHANG
Journal of Preventive Medicine 2019;31(4):341-345
Objective:
To investigate the epidemic status and influencing factors of colorectal polyps among urban residents in Lanxi.
Methods:
A representative urban community was selected from Lanxi. A total of 935 local residents aged 18-80 years received questionnaire survey,physical examination,laboratory tests and colonoscopy. Multivariate Logistic regression analysis was applied to exam the potential influencing factors for colorectal polyps.
Results :
Eventually 880 residents were involved into the statistical analysis. Colorectal polyps were detected in 167 participants with a crude prevalence of 18.98% and adjusted prevalence for age and gender of 13.28%. The prevalence of colorectal polyps in men(28.70%)was significantly higher than that in women(12.92%,P<0.05). The results of logistic regression analysis showed that age(OR=1.038,95%CI:1.018-1.057),males(OR=1.919,95%CI:1.303-2.826),the middle school level of education(OR=2.443,95%CI:1.507-3.961)and constitution of Yin-Asthenia(OR=0.203,95%CI:0.057-0.720)were influencing factors for colorectal polyps;among male participants,hypertension(OR=1.721,95%CI:1.018-2.908)was a risk factor for colorectal polyps;among female participants,age(OR=1.076,95%CI:1.042-1.111),BMI(OR=1.099,95%CI:1.001-1.207),the middle school level of education(OR= 3.507,95%CI:1.794-6.856)and constitution of Yin-Asthenia(OR=0.160,95%CI:0.033-0.770)were influencing factors for colorectal polyps.
Conclusion
Age,sex,education level and constitution of Yin-Asthenia were associated with the risk of colorectal polyps among residents in Lanxi;hypertension was associated with the risk of colorectal polyps in males,while age,BMI,education level and constitution of Yin-Asthenia were associated with the risk of colorectal polyps in females.
9.Relationship between different roles in campus bullying and depression
ZHANG Ziwei, LOU Chaohua, ZHONG Xiangyang, LIAN Qiguo, YU Chunyan, TU Xiaowen, ZUO Xiayun
Chinese Journal of School Health 2019;40(2):228-231
Objective:
To explore the relationship between different roles in campus bullying and depression among adolescents.
Methods:
Stratified cluster sampling method was used to select adolescents in grade 6-8 from three middle schools of Shanghai during November and December of 2017. Adolescents were surveyed anonymously using computer assisted self-interview approach via the tablets. Information including demographic characteristics, depression, and bullying was collected. The chi-square test and multivariate Logistic regressions were performed to explore the relationship between bullying roles and depression.
Results:
About 75.74% of the respondents were involved in bullying, including 456(27.65%) bystanders, 559(33.90%) victims, 33(2.00%) perpetrators, and 201 (12.19%) perpetrator-victims. There were 1 022(61.98%) respondents in the low depression group and 627 (38.02%) in the high depression group. Multivariate logistic regression showed that the four sub-groups involved in bullying all had higher level of depression than those uninvolved, with the perpetrator-victims (OR=4.77, 95%CI=3.27-6.96) and the victims (OR=3.66, 95%CI=2.71-4.94) had more depressive symptoms.
Conclusion
Different roles in campus bullying associates with more depressive symptoms, including perpetrators, victims, perpetrator-victims, and the bystanders.
10.Clinical analysis of neonatal Mycoplasma pneumoniae pneumonia and Chlamydia trachomatis pneumonia
Hui FENG ; Xiangyang PU ; Qin ZHONG ; Qi LU
Journal of Clinical Pediatrics 2018;36(6):447-452
Objective To explore the clinical characteristics of neonatal Mycoplasma pneumoniae pneumonia (MPP) and Chlamydia trachomatis pneumonia (CTP). Method The clinical data of neonatal MPP and CTP which diagnosis was confirmed from January 2013 to December 2016 were analyzed, and the newborns with other infectious pneumonia were selected as controls of MPP group and CTP group respectively according to the matching standard. Results There were 44 cases in MPP group, 30 cases in CTP group, 88 cases in MPP control group and 60 cases in CTP control group. In 44 cases of MPP group, 17 cases had the history of contact with respiratory infection patients (38.6%), 44 cases had cough (100.0%), 16 cases had fever (36.4%), 16 cases had diarrhea (36.4%), 10 cases had respiratory failure (22.7%), 9 cases had type II respiratory failure (20.5%), 4 cases had segmental consolidation (9.1%) and 5 cases had interstitial change (11.4%). The incidence rates above were higher than those in its control group, and the differences were statistically significant (P<0.05). In the 30 cases of CTP group, 26 cases were vaginal delivery (86.7%), 11 cases had premature rupture of membranes (36.7%), 28 cases had cyanosis (93.3%), 13 cases had diarrhea (43.3%), and 11 cases had eye secretion (36.7%). The incidence rates above were higher than those in the control group, and there were statistical differences (P<0.05). The proportion of vaginal delivery in CTP group was higher than that in MPP group, and the proportion of patients with the history of contact with respiratory tract infection patients was lower than that in MPP group , and there were statistical differences (P<0.05). Fever, cough, anhelation and fine wet rales were more common in MPP group than those in CTP group, and cyanosis and eye secretion were more common in CTP group than those in MPP group, and there were statistical differences (P<0.05). Patients in MPP group and CTP group were treated with macrolide antibiotics, and all of them were improved and discharged without any death. Conclusion Neonatal MPP is more susceptible to fever, cough, anhelation and fine wet rale in the lungs. The neonatal CTP is more likely to have cyanosis and eye secretions. Macrolide antibiotics can be used in both of them, and the prognosis is good.


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