Objective To investigate the effect of operation for hyperthyroidism assoiciated with hypokalemic periodic paralysis(HPP).Methods We retrospectively analysed the clinical data of 121 cases of hyperthyoidism associated with HPP.Among them 81 patients received subtotal thyroidectomy after taking Lugol solution for 2 weeks;40 patients received non-operative therapy.Results The plasma potassium,T3,T4,TSH and BMR levels of patients who received subtotal thyroidectomy were all normal 1 week post-operatively,Only 2 patients suffered symptoms of relapse at follow up of 0.5-10 years,with cure rate of 97.5%;8 of the patients who received non-operative therapy recovered,with cure rate of 20.0%.Conclusions Operation for hyperthyroidism associated with HPP could cure HPP and hyperthyroidism simultaneously.The therapeutic efficacy of operation is rapid and stable,and is markedly better than that of non-operative therapy.

Objective To inverstigate the effect and safety of refractory intrahepatic and extrahepatic bile duct stones treated by choledochoscope holmium laser combined with electrohydraulic lithotripsy.Methods The cllnical data of 67 cases of postoperative intrahepatic and extrahepatic bile duct stones treated with combined endoscopic holmium laser and electrohydraulic lithotripsy were analysed retrospectively.Results After 1 to 7 times of biliary endoscopic holmium laser electrohydraulic lithotripsy treatment,65 patients had complete removal of all residual stones with the success rate of 97%,and without complications.Conclusions After holmium laser combined with electrohydraulic lithotripsy,the effect of choledochoscopic removal of intrahepatic and extrahepatic bile duct residual stones can be greatly improved It is a safe method for treatment of refractory intra-and extra-hepatic bile duct stones.

Objective To observe the expressions of Clara cell secretary protein (CC16) mRNA and protein in senile rats. Methods The histological changes, the level of CC16 mRNA in lung tissue and CC16 protein in terminal bronchioles and respiratory bronchioles were measured in 10 senile rats (at the age of 26 months) and compared with 7 young rats (aged 3 months). Results The epithelial cells lined up irregularly in respiratory bronchioles and mild emphysema were found in the senile group. Compared with young group,the level of CC16 mRNA was decreased[(0.08v1.71) vs (10. 02?4. 66) , P

Objective:To understand the prevalence of other infectious diarrhea in Urumqi, Xinjiang from 2014 to 2018, to explore application of ARIMA model to predict other infectious diarrhea, and to provide a basis for scientific prevention and treatment.Methods:The epidemiological data of other perceptual diarrhea in a tertiary hospital from 2014 to 2018 and the data of laboratory test result in the " China Disease Prevention and Control Information System" were collected and sorted for descriptive epidemiological analysis, and SPSS software was used to predict the ARIMA model.Results:Other infectious diarrhea cases in a tertiary hospital from 2014 to 2018 were mainly concentrated in June to October (1 748 cases), accounting for 65.89% of the total cases in the whole year. Children under 10 years of age were the main population for other infectious diarrhea (1 699 cases), accounting for 49.26%. Rotavirus infection was the main cause of other infectious diarrhea (339 cases), accounting for 93.38% of all detected pathogens. ARIMA (0, 1, 2)(0, 1, 1) 12 was the optimal model, which verified that the average relative error of the number of cases in Urumqi from January to December in 2018 was 20%, and the actual value was within the 95% confidence interval of the predicted value. Conclusions:Health education on the prevention of other infectious diarrhea should be strengthened for children under 10 years of age and their parents in Urumqi, focusing on rotavirus diarrhea, and the promotion and vaccination of rotavirus vaccine for children under 10 years old should be done well. ARIMA (0, 1, 2)(0, 1, 1) 12 has certain value in predicting the incidence of other infectious diarrhea.

Objective To analyze the epidemiological characteristics of bacillary dysentery in Xinjiang from 2005-2018, to explore the feasibility and applicability of seasonal autoregressive moving average model to predict the incidence pattern of bacillary dysentery in Xinjiang, and to provide a scientific basis for decision-making in the prevention and control of bacillary dysentery. Methods Descriptive analysis was used to analyze the epidemiological characteristics of bacillary dysentery, and Python software was used to construct a SARIMA model and predict the incidence trend. Results The average annual reported incidence rate of bacillary dysentery in Xinjiang from 2005-2018 was 35.71/100 000, with peak incidence concentrated in June-October. The difference in the incidence rate of bacillary dysentery among the age groups was statistically significant (χ²=145605.90, P<0.001), with a larger proportion of illnesses in the 0-5 and >60 years age groups. The resulting model was SARIMA (0,1,2)(0,1,1)₁₂ with all parameters statistically significant (P<0.05). The Ljung-Box Q test (LBQ) was performed on the residual series and the difference was not statistically significant (LBQ=0.68, P=0.41), i.e., the residual series was white noise. The relative errors of the predicted and observed values ranged from 3.29% to 75.32%, with a mean relative error of 11.34%. The optimal SARIMA model constructed was used to predict the incidence trend from 2019 based on monthly incidence data of bacillary dysentery from 2005-2018, which showed a year-on-year decline in incidence. Conclusion The SARIMA (0,1,2)(0,1,1)₁₂ model has good accuracy in predicting the incidence of bacillary dysentery in Xinjiang and can be used for medium-term prediction of the disease.

Objective Establishing an integrated assessment index system in order to strengthen the multi-dimen-sional evaluation for scientific research performance of medical staff in tertiary general hospital.Methods The method of documentary and Delphi are used in filtering the indexes of medical personnel's scientific research performance evaluation and the method of analytic hierarchy process is used in ascribing different weights for each index that the consistency is tested.Results There are two evaluation index systems in the Evaluation System of medical research performance in tertiary general hospital.The first one is Medical Staff's Scientific Research Ability Evaluation System.There are 51 indexes in the system,including 2 first-level indexes,1 second-level indexes and 38 third-level indexes.The second system is Scientific Research Performance Evaluation Index System,which have 70 indicators,including 4 first-level indicators,15 second-level indicators,51 third-level indicators.Conclusion The index system of scientific research performance evaluation has a high credibility,and can be popularized as an index of scientific research performance evaluation for medical staff in hospital based on the practice evaluation.The system could provide data support for hospital to implement more accurate scientific research management policy.

Objective By analyzing the practical management of daytime surgery in a large public hospital in Xinjiang Uygur Autonomous Region,this paper aims to provide a reference for optimizing the management of daytime surgery.Methods Based on hospital management,the management experiences of daytime surgery from 2017 to 2022 were analyzed from the per-spectives of building the management system of daytime surgery and optimizing the management model.Results Since 2017,the hospital has initiated the pattern of pilot daytime surgery,from opening a green channel for daytime surgery,setting up daytime wards,to conducting daytime chemotherapy,continuously increasing the disease types for daytime surgery and procedures.This has led to the full development of 708 procedures in the national recommended daytime surgery catalogue,with the proportion of daytime surgery in elective surgeries gradually rising to 23.83 percent.The management of daytime surgery has achieved achieve-ments.Conclusion The current regulatory scope of daytime surgery depends on its definition.Therefore,hospitals should pur-sue innovative initiatives for daytime diagnosis and treatment in line with the hospital actualities and the development of medical disciplines.This will further enhance the regulatory and incentive mechanisms for daytime surgery pattern,aiding public hospitals to develop in a high-quality manner.

Objective:To explore the effects of rhubarb enema combined with intra-abdominal pressure (IAP) monitoring in enteral nutrition (EN) therapy among critical patients.Methods:From August 2017 to August 2018, this study selected 68 EN patients of ICU at a Class Ⅲ Grade A hospital in Hangzhou as subjects by convenience sampling. All of patients were randomly divided into experimental group and control group, 34 cases in each group. Control group carried out the EN treatment guided by IAP monitoring. On the basis, experimental group combined the rhubarb enema for 5 days. This study compared the score of Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ, IAP, incidence of feeding intolerance (FI) and feeding volume reaching the standard of patients between two groups.Results:After intervention, the score of APACHE Ⅱ of patients in experimental group was lower than that in control group with no statistical difference ( P>0.05) . The IAP of patients in experimental group was lower than that in control group with a statistical difference ( P<0.01) . The time of feeding volume reaching the standard of patients in experimental group was shorter than that in control group with a statistical difference ( P<0.01) . The incidence of FI of experimental group was lower than that in control group with a statistical difference ( P<0.05) . Conclusions:Rhubarb enema combined with IAP monitoring can reduce the IAP of critical patients, shorten the time of feeding volume reaching the standard and reduce the incidence of FI.

Background::Gastric cancer (GC), a malignant tumor with poor prognosis, is one of the leading causes of cancer-related deaths worldwide; consequently, identifying novel therapeutic targets is crucial for its corresponding treatment. NUF2, a component of the NDC80 kinetochore complex, promotes cancer progression in multiple malignancies. Therefore, this study aimed to explore the potential of NUF2 as a therapeutic target to inhibit GC progression. Methods::Clinical samples were obtained from patients who underwent radical resection of GC at Lanzhou University Second Hospital from 2016 to 2021. Cell count assays, colony formation assays, and cell-derived xenotransplantation (CDX) models were used to determine the effects of NUF2 on GC progression. Flow cytometry was used to detect the effect of NUF2 or quercetin on cell cycle progression and apoptosis. A live-cell time-lapse imaging assay was performed to determine the effect of NUF2 on the regulation of mitotic progression. Transcriptomics was used to investigate the NUF2-associated molecular mechanisms. Virtual docking and microscale thermophoresis were used to identify NUF2 inhibitors. Finally, CDX, organoid, and patient-derived xenograft (PDX) models were used to examine the efficacy of the NUF2 inhibitor in GC. Results::NUF2 expression was significantly increased in GC and was negatively correlated with prognosis. The deletion of NUF2 suppressed GC progression both in vivo and in vitro. NUF2 significantly regulated the mitogen-activated protein kinase (MAPK) pathway, promoted G2/M phase transition, and inhibited apoptosis in GC cells. Additionally, quercetin was identified as a selective NUF2 inhibitor with low toxicity that significantly suppressed tumor growth in GC cells, organoids, CDX, and PDX models. Conclusions::Collectively, NUF2-mediated G2/M phase transition and apoptosis inhibition promoted GC progression; additionally, NUF2 inhibitors exhibited potent anti-GC activity. This study provides a new strategy for targeting NUF2 to suppress GC progression in clinical settings.

Threatened abortion is a common disease of obstetrics and gynecology and one of the diseases responding specifically to traditional Chinese medicine （TCM）. The China Association of Chinese Medicine organized experts in TCM obstetrics and gynecology， Western medicine obstetrics and gynecology， and pharmacology to deeply discuss the advantages of TCM and integrated Chinese and Western medicine treatment as well as the medication plans for threatened abortion. After discussion， the experts concluded that chromosome， endocrine， and immune abnormalities were the key factors for the occurrence of threatened abortion， and the Qi and blood disorders in thoroughfare and conception vessels were the core pathogenesis. In the treatment of threatened abortion， TCM has advantages in preventing miscarriages， alleviating clinical symptoms and TCM syndromes， relieving anxiety， regulating reproductive endocrine and immune abnormalities， personalized and diversified treatment， enhancing efficiency and reducing toxicity， and preventing the disease before occurrence. The difficulty in diagnosis and treatment of threatened abortion with traditional Chinese and Western medicine lies in identifying the predictors of abortion caused by maternal factors and the treatment of thrombophilia. Recurrent abortion is the breakthrough point of treatment with integrated traditional Chinese and Western medicine. It is urgent to carry out high-quality evidence-based medicine research in the future to improve the modern diagnosis and treatment of threatened abortion with TCM.