Objective To discuss the effectiveness of comprehensive intervention of cognitive behavior on the symptoms of pain , fatigue and sleep disorders for patients with advanced cancer .Methods Sixty-two patients with advanced cancer were divided into the experimental group ( n=32 ) and the control group ( n=30).The experimental group was given relaxation exercises and natural image intervention .Then the digital pain evaluation , brief fatigue inventory ( BFI ) , Pittsburgh sleep quality index ( PSQI ) and the Anderson symptom inventory ( MDASI ) were applied to analyze the differences between the experimental group and the control group.Results Pain, fatigue, poor appetite and sleep disorder were the most common symptoms , and the incidence of these symptoms were 95.1%, 92.6%, 88.5% and 86.1%, respectively.The average pain score of patients in the experimental group was (2.47 ±0.53), which was significantly lower than (5.54 ± 0.37) of patients in the control group, with a significant difference(t=2.84,P<0.01).The score of BFI for patients in the experimental group was (3.44 ±1.24), which was significantly lower than (4.92 ±0.41) of patients in the control group, with a significant difference (t=2.47,P<0.05).The score of PSQI for patients in the experimental group was (2.67 ±0.73), which was significantly lower than (5.18 ±1.09) of patients in the control group, with a significant difference (t =5.34,P <0.01).Conclusions The cognitive behavior intervention can effectively alleviate symptoms including pain , fatigue, and sleep disorder for patients with advanced cancer .