Objective:To investigate the clinical characteristics of idiopathic hypereosinophilic syndrome (IHES) with gastrointestinal manifestations,and to improve the level of diagnosis and treatment of IHES. Methods:The clinical materials, process of diagnosis and treatment and prognosis of 9 patients diagnosed as IHES with gastrointestinal manifestations were retrospectively analyzed. Results:The average age of 9 patients was (22.66± 12.86)years old,and the ratio of male and female was about 1.25∶ 1. The main clinical manifestations included abdominal pain,diarrhea and abdominal distension.The eosinophil percentages in peripheral blood and bone marrow of the patients were (42.66 ± 19.88 )% and (39.33 + 15.99 )%, respectively.The ascites exudate cytology examination showed eosinophil infiltrated.The results of gastroscope or colonoscope showed mucosal hyperemia and edema,scattered bleeding spots, and dark red granular hyperplasia; the colon was affected frecuently.The histological biopsy confirmed that the mucosal was infiltrated by eosinophils.The abdominal CT of 6 patients showed that the walls of stomach or bowel were thickened.The abdominal symptoms disappeared,and the ascites was absorpted in 9 patients after the treatment of glucocorticoid.After 2 years of follow up,2 patients had relapse, others had no recurrence.Conclusion:Performing the routine diagnosis and treatment of gastrointestinal diseases, the clinicians should consider the possibility of IHES in order to avoid the misdiagnosis and delayed treatment. When IHES is diagnosed,steroid treatment should be performed in preference.

Cerebrovascular disease,Alzheimer's disease,Parkinson's disease and other chronic encephalopathy has become a worldwide public health problem.Cognitive impairment,including mild cognitive impairment to dementia,is closely related to chronic encephalopathy,especially cerebrovascular diseases.Early detection,early diagnosis,early treatment of cognitive impairment has become the focus of the research,in order to reduce the development of dementia,improve the quality of life and reduce the burden of disease.This article elaborates the research progress of cognitive impairment from the aspects of pathological mechanisms,risk factors,clinical diagnosis and strategy prevention and control,and the arguments of domestic experts.

Objective To establish sensitive indicators for the evaluation of emergency nursing quality in patients with acute aortic dissection.Methods Based on the three-dimensional quality theory model of"structure-process-outcome",evidence-based nursing methods were used to synthe-size evidence and conduct two rounds of expert consultation to determine sensitive indicators for the quality of emergency nursing in patients with acute aortic dissection.Results The effective recovery rates of the two rounds of expert consultation questionnaires were 100.00％and 94.12％,respective-ly.The judgment basis coefficients(Ca)of the experts who participated in the two rounds of consul-tation were 0.893 and 0.914,respectively,and the familiarity coefficients(Cs)were 0.902 and 0.921,respectively,and the authority coefficients(Cr)were 0.898 and 0.918,respectively.The Kendall coefficients of the first round of consultation experts for the first,second,and third-level indi-cators were 0.212,0.247,and 0.327,respectively,and were 0.225,0.349,and 0.257,respec-tively in the second round of consultation experts.Finally,the sensitive indicators for the quality of e-mergency nursing of AAD patients were constructed,including 3 first-level indicators,8 second-level indicators,and 29 third-level indicators.Conclusion The sensitive indicators for the quality of e-mergency nursing of AAD patients constructed in this study can be used as a basis for evaluating the quality of emergency nursing in patients with acute aortic dissection.

Objective To establish sensitive indicators for the evaluation of emergency nursing quality in patients with acute aortic dissection.Methods Based on the three-dimensional quality theory model of"structure-process-outcome",evidence-based nursing methods were used to synthe-size evidence and conduct two rounds of expert consultation to determine sensitive indicators for the quality of emergency nursing in patients with acute aortic dissection.Results The effective recovery rates of the two rounds of expert consultation questionnaires were 100.00％and 94.12％,respective-ly.The judgment basis coefficients(Ca)of the experts who participated in the two rounds of consul-tation were 0.893 and 0.914,respectively,and the familiarity coefficients(Cs)were 0.902 and 0.921,respectively,and the authority coefficients(Cr)were 0.898 and 0.918,respectively.The Kendall coefficients of the first round of consultation experts for the first,second,and third-level indi-cators were 0.212,0.247,and 0.327,respectively,and were 0.225,0.349,and 0.257,respec-tively in the second round of consultation experts.Finally,the sensitive indicators for the quality of e-mergency nursing of AAD patients were constructed,including 3 first-level indicators,8 second-level indicators,and 29 third-level indicators.Conclusion The sensitive indicators for the quality of e-mergency nursing of AAD patients constructed in this study can be used as a basis for evaluating the quality of emergency nursing in patients with acute aortic dissection.

ObjectiveTo investigate the association between ZJU index and the onset of nonalcoholic fatty liver disease （NAFLD） in the Uygur population and the value of ZJU index in predicting the risk of NAFLD. MethodsThe Uighur community of The 51st Regiment of The Third Division of Xinjiang Kashgar Corps was selected as the investigation site， and the Uygur residents who lived in this area and had an age of >18 years were selected as subjects. Follow-up studies were conducted in 2019， 2020， and 2021， and the investigation of outcomes was completed in June to August of 2021. Finally 10 597 subjects were enrolled for analysis. The Kruskal-Wallis H test was used for comparison of continuous variables between groups， and the chi-square test was used for comparison of categorical variables between groups. The subjects were divided into Q1-Q4 groups according to the level of ZJU index. The Kaplan-Meier curve was used to predict the incidence rate of NAFLD， and the Cox regression model was used to analyze the association between ZJU index and the risk of NAFLD； the area under the ROC curve （AUC） was used to evaluate the value of ZJU index in predicting the risk of NAFLD. ResultsDuring the median follow-up time of 4.92 years， the incidence rate of NAFLD was 9.4% （992/10 597） among the study population. After adjustment for multiple factors， there was a significant increase in the risk of NAFLD with the increase in ZJU index， with a hazard ratio of 2.55 （95% confidence interval ［CI］： 1.60‍ — ‍4.06）， 7.32 （95%CI： 4.78‍ — ‍11.20）， and 21.74 （95%CI： 14.32‍ — ‍33.00）， respectively （all P_trend<0.001）. The ROC curve showed that ZJU index had a higher value in predicting NAFLD （AUC=0.816）， and the male subgroup had a significantly higher predictive accuracy of ZJU index than the female subgroup （AUC： 0.829 vs 0.809）. ConclusionZJU index is a predictive factor for the onset of NAFLD in the Uygur population in rural areas of Xinjiang and has a good value in predicting the risk of NAFLD.