The research on relation between cancer and adaptive immunity is developing in depth. One of its signs is to optimize the key molecules and their pathways for regulating adaptive immunity through high-throughput molecular bioinformatics analysis. Based on the fact that cancer is an uncontrolled inflammation, adaptive immune-related cells are the main members driving the development of controllable inflammation to non-controllable inflammation, and the research on its molecular regulatory mechanism is a hot topic nowadays. Based on the in-depth sequencing database and bioinformatics analysis of the non-controllable growth (malignant transformation) of these adaptive immune-related cells, the research progress of Toll-like receptors and chemokines is summarized as follows.