1.Evaluating the growth of pulmonary nodular ground-glass opacity on CT: Comparison of volume rendering and thin slice images.
Mingzhu, LIANG ; Xueguo, LIU ; Weidong, LI ; Kunwei, LI ; Xiangmeng, CHEN ; Guojie, WANG ; Kai, CHEN ; Jinxin, ZHANG
Journal of Huazhong University of Science and Technology (Medical Sciences) 2011;31(6):846-51
This study examined the value of volume rendering (VR) interpretation in assessing the growth of pulmonary nodular ground-glass opacity (nGGO). A total of 47 nGGOs (average size, 9.5 mm; range, 5.7-20.6 mm) were observed by CT scanning at different time under identical parameter settings. The growth of nGGO was analyzed by three radiologists by comparing the thin slice (TS) CT images of initial and repeat scans with side-by-side cine mode. One week later synchronized VR images of the two scans were compared by side-by-side cine mode to evaluate the nGGO growth. The nodule growth was rated on a 5-degree scale: notable growth, slight growth, dubious growth, stagnant growth, shrinkage. Growth standard was defined as: Density increase ≥ 30 HU and (or) diameter increase (by 20% in nodules ≥10 mm, 30% in nodules of 5-9 mm). Receiver operating characteristic (ROC) was performed. The results showed that 32 nGGOs met the growth criteria (29 nGGOs showed an increase in density; 1 nGGO showed an increase in diameter; 2 nGGOs showed an increase in both diameter and density). Area under ROC curve revealed that the performance with VR interpretation was better than that with TS interpretation (P<0.01, P<0.05 and P<0.05 for observers A, B and C respectively). Consistency between different observers was excellent with both VR interpretation (κ=0.89 for observers A&C, A&B, B&C) and TS interpretation (κ=0.71 for A&B, κ=0.68 for A&C, κ= 0.74 for B&C), but time spending was less with VR interpretation than with TS interpretation (P<0.0001, P<0.0001 and P<0.05 for observers A, B and C, respectively). It was concluded that VR is a useful technique for evaluating the growth of nGGO.
2.Evaluating the Growth of Pulmonary Nodular Ground-glass Opacity on CT: Comparison of Volume Rendering and Thin Slice Images
LIANG MINGZHU ; LIU XUEGUO ; LI WEIDONG ; LI KUNWEI ; CHEN XIANGMENG ; WANG GUOJIE ; CHEN KAI ; ZHANG JINXIN
Journal of Huazhong University of Science and Technology (Medical Sciences) 2011;31(6):846-851
This study examined the value of volume rendering (VR) interpretation in assessing the growth of pulmonary nodular ground-glass opacity (nGGO).A total of 47 nGGOs (average size,9.5mm; range,5.7-20.6 mm) were observed by CT scanning at different time under identical parameter settings.The growth of nGGO was analyzed by three radiologists by comparing the thin slice (TS) CT images of initial and repeat scans with side-by-side cine mode.One week later synchronized VR images of the two scans were compared by side-by-side cine mode to evaluate the nGGO growth.The nodule growth was rated on a 5-degree scale:notable growth,slight growth,dubious growth,stagnant growth,shrinkage.Growth standard was defined as:Density increase ≥ 30 HU and (or) diameter increase (by 20% in nodules ≥10 mm,30% in nodules of 5-9 mm).Receiver operating characteristic (ROC) was performed.The results showed that 32 nGGOs met the growth criteria (29 nGGOs showed an increase in density; 1 nGGO showed an increase in diameter; 2 nGGOs showed an increase in both diameter and density).Area under ROC curve revealed that the performance with VR interpretation was better than that with TS interpretation (P<0.01,P<0.05 and P<0.05 for observers A,B and C respectively).Consistency between different observers was excellent with both VR interpretation (κ=0.89 for observers A&C,A&B,B&C) and TS interpretation (κ=0.71 for A&B,κ=0.68 for A&C,κ=0.74 for B&C),but time spending was less with VR interpretation than with TS interpretation (P<0.0001,P<0.0001 and P<0.05for observers A,B and C,respectively).It was concluded that VR is a useful technique for evaluating the growth of nGGO.
3.Research status and application prospect of hemoglobin-based oxygen carriers in organ transplantation
Kewei YOU ; Jiaxin LIU ; Xiangmeng WANG ; Wengang WANG
Chinese Journal of Blood Transfusion 2022;35(8):810-813
Hemoglobin-based oxygen carriers(HBOCs) is a category of artificial blood substitute with efficient oxygen carrying and delivery functions. Due to the outstanding oxygen-carrying properties of HBOCs, the studies of expanding its clinical applications are undergoing rapidly. Studies have shown the efficacy of HBOCs in organ transplantation as machine perfusion solution in maintaining the organ metabolism or meliorating the margin donor organ quality with promising perspectives. This article aims to review the application status and prospect of HBOCs in organ transplantation in recent years.
4.The lethal effect of disulfiram/cooper complex in NOD/SCID mouse model with acute myeloid leukemia.
Huijuan DONG ; Rongwei LI ; Zhongxin ZHENG ; Han HE ; Yong ZHOU ; Manman DENG ; Yin LI ; Xiangmeng WANG ; Shuyun ZHOU ; Bing XU
Chinese Journal of Hematology 2014;35(9):848-850
Animals
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Copper
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toxicity
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Disulfiram
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toxicity
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Humans
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Leukemia, Myeloid, Acute
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Mice
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Mice, Inbred NOD
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Mice, SCID