1.Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions.
Yufei YANG ; Mo HU ; Kaiwen YU ; Xiangmei ZENG ; Xiaoyun LIU
Protein & Cell 2015;6(4):265-274
Elucidation of molecular mechanisms underlying host-pathogen interactions is important for control and treatment of infectious diseases worldwide. Within the last decade, mass spectrometry (MS)-based proteomics has become a powerful and effective approach to better understand complex and dynamic host-pathogen interactions at the protein level. Herein we will review the recent progress in proteomic analyses towards bacterial infection of their mammalian host with a particular focus on enteric pathogens. Large-scale studies of dynamic proteomic alterations during infection will be discussed from the perspective of both pathogenic bacteria and host cells.
Animals
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Bacteria
;
chemistry
;
pathogenicity
;
Bacterial Infections
;
microbiology
;
pathology
;
Bacterial Proteins
;
isolation & purification
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metabolism
;
Host-Pathogen Interactions
;
Humans
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Mass Spectrometry
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Protein Processing, Post-Translational
;
Proteomics