Objective To explore the clinical effects and safety of radiofrequency thermocoagulation combined with ozone injection in the treatment of failed back surgery syndrome (FBSS). Methods A total of 58 patients suffered from FBSS were treated with radiofrequency thermocoagulation and ozone injection from October 2006 to December 2012.The changes of lumbar and leg functions were observed .The evaluation of clinical efficacy was made by visual analogue scale ( VAS) and Oswestry disability index (ODI) at one week, one month, three months, six months, and twelve months postoperatively , respectively. Results The operation was successfully completed in all the 58 patients , without serious complications .All the cases were followed for one year .The ODI was 20.3 ±3.1 at the last follow-up, which was significantly lower than that before operation (79.8 ±2.6, t=96.871, P=0.000).The VAS of back pain was (7.6 ±0.4) points preoperatively and (3.1 ±0.2) points at the last follow-up, which also showed statistical significance (t=45.206, P=0.000).According to the modified MacNab criteria, clinical outcomes showed excellent in 18 cases and good in 23 cases, with an excellent and good rate of operation being 70.7% (41/58). Conclusion Treatment of FBSS by using radiofrequency thermocoagulation and ozone injection is an effective option .

OBJECTIVETo observe the effects of Fructus Corni polysaccharides (FCP) on sexual function of hemicastrated rats.

METHOD70 male SD rats are randomly divided into 7 groups with their right testis extirpated except for normal control group. Normal control group and negative control group are given saline (ig) while positive control group are injected hypodermically testosterone propionate at dose of 2 mg x kg(-1) x d(-1). FCP control groups are given FCP separately at dose of 10, 50, 100, 150 mg x kg(-1) x d(-1) (ig). Mating test and erective test are observed. The levels of serum sex hormone T, LSH, FSH, E2 are detected with the Radioimmunoassay (RIA).

RESULTIncubation period of penis erection and mounting are shortened in FCP control groups and positive control group, and the percentage of mounting rats is increased. The level of serum sex hormone T is increased, but estradiol level is reduced. The organ coefficient of foreskin gland and seminal vesicle-prostate gland as well as sperm count and vigor are increased significantly (P < 0.01 or P < 0.05).

CONCLUSIONFCP can increase the sexual function of hemicastrated rats. The mechanism is probably through adjustment of the hypothalamus-pituitary-gonadal axis.

Animals ; Cornus ; chemistry ; Female ; Male ; Penile Erection ; drug effects ; Polysaccharides ; pharmacology ; toxicity ; Rats ; Rats, Sprague-Dawley ; Sexual Behavior, Animal ; drug effects ; Sexual Dysfunction, Physiological ; chemically induced ; Testis ; drug effects ; physiology

Objective: To obtain the dietary exposure of lead in primary, middle and high school students, and to provide basic foundation for food safety risk assessment and management for children and adolecsents. Methods: Weighing method, 3-days hour dietary survey, combining with the food frequency questionnaire, was applied to obtain basic dietary data in 616 primary, middle and high school students selected through multi-stage randdom sampling method from Pudong new area of shanghai. Data on lead concentrations were derived from the food safety risk monitoring system, which included 1 145 samples. Results: Lead was detected in 568 of 1 145 samples (49.61%) from 10 categories of foods. The exceeding standard rate was 3.58% (41 samples exceeded). The average content of lead was (0.12±0.25) mg/kg, fungi and algae, beans and the aquatic products were found to be the primary food sources of lead exposure. The average dietary lead exposure in primary, middle and high school students was 9.94 μg/kg per week, accounted for 39.76% of PTWI. The lead exposure level at the 97.5th percentile which accounted for 118.24% of PTWI was 29.56 μg/kg. Vegetables, beans and cereal foods were the mainly source of dietary lead exposure, with average dietary lead exposure 2.57, 2.44 and 1.43 μg/kg peer week, accounted for 10.26%, 9.76% and 5.74% of PTWI, respectively. Conclusion Lead is present in some foods available in local markets in Pudong New Area, Shanghai. Low level of dietary exposure to lead is found in primary, middle and high school students, however, it depends on dietary pattern. Continued efforts are needed to reduce the dietary exposure of lead in school students.