Objective:To investigate the imaging follow-up value of discectomy and Modic changes caused by endolate fracture.Methods:Forty-six patients with end-plate fractures admitted to Changxing People′s Hospital during January to December 2016 were selected as subjects and followed up for 1 year. All patients underwent MRI examination to analyze the changes of Modic, disc degeneration and lumbar function recovery before and after follow-up.Results:A total of 230 lumbar intervertebral discs in 46 patients in this group had Modic changes. After 1 year′s follow-up, Modic changes occurred in 185 lumbar intervertebral discs in 46 patients. Modic changes occurred in L 5-S 1 [38.92%(72/185)] and L 4 - L 5 [40.0%(74/185)] segments. After 1 year′s follow-up, the rate of intervertebral disc 3-4 grade was higher than that before discharge [70.43%(162/230) vs. 60.43%(139/230)], the rate of intervertebral disc 6-8 grade was lower than that before discharge[8.70%(20/230) vs. 15.22%(35/230)], and the differences were statistically significant ( χ2 = 5.085, 4.646, P<0.05). After 1 year′s follow-up, the lumbar spine function score was significantly higher than that before discharge [(23.47 ± 2.86) scores vs. (9.15 ± 1.32) scores], and the difference was statistically significant ( P<0.05). Conclusions:Diffusion-weighted MR imaging has the characteristics of convenient operation, good repeatability and high accuracy. It is suitable for diagnosis and follow-up of disc degeneration and Modic change caused by endplate fracture. It is worthy of clinical promotion.

Objective To investigate the effect evaluation of nurse manager′s nursing round system on improving ward nursing management level. Methods The self-designed nurse manager′s nursing round observe evaluation form and effect evaluation questionnaire were used to comprehensively evaluate implementation and effects of nurse manager′ s nursing round system. Results The nurse manager′ s nursing round observe evaluation form score was (95. 05 ± 2. 75), the scores of nurse manager′s nursing round system evaluated by patients, nurses and nurse manager were (33. 70 ± 2. 65),(49. 73 ± 0. 98) and (33. 05 ± 3. 86). Multivariate analysis showed that, increase nurses′ attention, increase a sense of security and belonging, enhance the ability of nurses to report illness and critical thinking ability, improve overall care quality can improve evaluation for the system(P < 0. 05). Conclusions The establishment and implementation of nurse manager′s nursing rounds system has improved the wards nursing management level, and patients, nurses and nurse managers give high evaluations for the system.

We herein describe AncPhore, a versatile tool for drug discovery, which is characterized by pharmacophore feature analysis and anchor pharmacophore (