Objective To explore the effect of pyrrolidine dithiocarbamate(PDTC) on the expression of E-selectin and the activities of enzymes in oxidative stress in the pancreas of rats with severe acute pancreatitis(SAP).Methods Rat model of ASP was build by intraperitoneal injection of L-arginine(totally 5 g/kg,twice in an interval of 1 h).Thirty-six SD rats were assigned to 6 groups randomly and equally,that is,normal control,SAP,PDTC pretreatment group 1(1 mg/kg) and 2(100 mg/kg),and PDTC treatment group 1(1 mg/kg) and 2(100 mg/kg).PDTC pretreatment was preformed by subcutaneous injection of PDTC 1 h before first injection of L-arginine.For the animals in treatment groups,PDTC was given 3 h after first injection.Normal control was given intraperitoneal injection of normal saline.In 24 h after the first injection of L-arginine,the activity of myeloperoxidase(MPO),lipid peroxide(LPO) and nitric oxide synthase(NOS) were detected.Expressions of E-selectin was detected through inmmunohistochemical method,and activity of NF-?B-DNA binding were detected by electrophoretic mobility shift assay(EMSA).Results In SAP groups and PDTC pretreatment and treatment groups,the expression of E-selectin,activities of NF-?B,MPO,LPO,and inducible NOS(iNOS) were higher,but the activity of constitutive NOS(cNOS) was lower than those in the normal control(P0.05).Conclusion PDTC of 1 mg/kg can alleviate the inflammation in SAP by blocking the translocation of NF-?B,however,the 100 mg/kg PDTC shows little protection in this process.

Objective To estimate the prevalence and associated factors of adult female urinary incontinence in Hebei province. Methods Stratified and multistage sampling method was used, between January 2016 to May 2016, to investigate the target population in Hebei province. While, logistic regression was used to analyse datas. Results A population-based survey was conducted in 2 450 women in Hebei province, there were 2 408 effective questionnaires after deleting 48 invalid questionnaires. According to the results, the average age of subjects was (56±15) years old, and the urinary incontinence prevalence of adult female in Hebei province was 27.70%(667/2 408). Stress urinary incontinence, urge urinary incontinence and mixed urinary incontinence were diagnosed as 23.13%(557/2 408), 1.58%(38/2 408) and 2.99%(72/2 408), respectively. There were only 2.85% (19/667) urinary incontinence patients seeking medical help. The results of logistic regression analysis showed that age, daily water intake, pulmonary diseases, urinary tract infection, hypertension, chronic low back pain, dysmenorrhea, vaginitis, abortion, mode of delivery, postpartum infection were statistically significant (all P≤0.05). Among these factors, cesarean section was the protective factor for urinary incontinence (OR=0.365, 95%CI: 0.195-0.685, P<0.01). Conclusions The prevalence of urinary incontinence in adult female in Hebei province is high, and there are few patients seeking medical help. It is a common disorder in women and is associated with many factors;among these factors, cesarean section is the protective factor for urinary incontinence.