Objective To evaluate the effect of low-dose omeprazole in the treatment of functional dyspepsia(FD).Methods A total of 260 FD patients were diagnosed clearly and divided into two groups randomly:148 cases(observation group)were treated with low-dose omeprazole(10 mg/d),while 112 cases(control group)were treated with esomeprazole(20 mg/d)and domperidone(each 10 mg,three times per day).Two groups were all treated for 2 weeks.The clinical symptoms such as heartburn,postprandial distenstion,epigastric pain and eructation were observed.Results Compared with symptoms in two groups before treatment,the scores of heartburn and epigastric pain were decreased evidently after treatment in two groups(P

Objective To study the effects of simulated gravity loss on nuclear factor Kappa-B expression in rats′ pulmonary tissue, and to investigate the mechanism of changes in NF-?B during simulated loss of gravity. Methods Tail-suspension(TS) was used as the method to simulate the physiological effects of weightlessness. 40 Wistar male rats Wistar rats were randomly divided into 4 groups: control for 7 days (7d CON), 21d CON, TS for 7d (TS7d) and TS21d. The dynamic express of nuclear factor Kappa-B in lung tissue was respectively assessed using the immunohisochemical technique. Results Compared with control group, the expression level of NF-?B in the lung tissue of tail-suspension 7d rats was elevated significantly (P

Objective To study the pain relief effectiveness of the combined spinal epidural analgesia(CSEA) and the inhalation of nitrous oxide, and the influences on the mothers and infants Methods The 300 cases of pregnant women were randomly divided into 3 groups: CSEA group,nitrous oxide group and control group The nitrous oxide group was that pregnant women inhaled nitrous oxide premixed with oxygen (50%∶50%),the pregnant women of the CSEA group were injected fentanyl and bupivacaine in the subarachnoid and epidural space,analgesic was not used in the control group The degree of labor pain, duration of the labor,way of delivery, bleeding volume, rate of anoxia of newborn,blood gas analysis to maternal radius artery and fetal umbilical blood among 3 groups were observed Results The effect for analgesia labor of the CSEA group was much better than that of the nitrous oxide group ( P 0 05) In the second stage of labor,the 3 groups were alike to each other The bleeding volume of caesarean section (373?77) ml in the nitrous oxide group was much more than the other 2 groups, there was no difference between the CSEA group (259?78) ml and the control group (239?89) ml The rate of obstetric forceps of CSEA group was higher than the control group ( P

OBJECTIVE:To explore the effects of Haikangling Mixture on immunological function in immunosuppressed mice induced by cyclophosphamide. METHODS: Mice were given Haikangling Mixture intragastrically for 14d, and the level of hemolysin was determined by sheep erythrocyte (SRBC) immunization to exploer the influence of Haikangling on humoral immunity in mice; splenic lymphocytes were measured by MTT to observe the influence on cell immunity; the clearance of macrophage were measured by carbon particle clearance method to explore the influence on non-specificity immunity. RESULTS: The level of hemolysin, the cell reproductive activity, splenic lymphocytes and the phagotrophy of mononuclear macrophage were improved obviously by Haikangling Mixture in immunosuppressed mice induced by cyclophosphamide. CONCLUSION: Haikangling Mixture can enhance the immunological function in immunosuppressed mice induced by cyclophosphamide.

Objectives To investigate the diagnostic value and safety of needle cutting biopsy for the primary and metastatic hepatic cancer during the treatment of percutaneous radiofrequency ablation and ethanol injection guided by ultrosound or CT. Methods The clinical data of 48 patients underwent the treatment of percutaneous radiofrequency ablation and ethanol injection as well as biopsy were analyzed. Results Among 48 patients,46 case(95.8%) were diagnosed by pathological examination and 2 cases (4.2%) failed to be diagnosed. There were no serious complications in all the patients. Conclusion Detachable needle cutting biopsy was safe and effective for the diagnosis of the primary and metastatic hepatic cancer during the treatment of percutaneous radiofrequency ablation and ethanol injection guided by ultrasound or CT.

Objective To investigate the neuroprotective potentials of recombinant human erythropoietin ( rhEPO) in premature rats with white matter damage. Methods Pregnant rats ( gestational age 15 days) were injected lipopolysaccharide (LPS) (300 μg/kg) intraperitoneally to make cerebral white matter lesions. Another 10 cases of pregnant rats were injected saline (1 mL/kg) intraperitoneally as controls. All preterm rats were born by caesarean sec-tion on embryonic day 21. According to the different processing method,the preterm rats were randomly divided into LPS+rhEPO group (18 cases),LPS+ normal saline (NS) group (18 cases),NS+rhEPO group (18 cases) and NS+NS group (18 cases) ,and they were injected rhEPO (5 000 IU/kg) or 9 g/L saline 1 mL/kg intraperitoneally imme-diately after birth,respectively. The cerebral white matter injury was evaluated with HE staining,and levels of CD68 ,gli-al fibrillary acidic protein (GFAP),myelin basic protein (MBP) were detected by immunofluorescence method 3 and 7 days after birth. Assessment of nerve behavior was done 2 weeks after birth. Results HE staining showed that the white matter lesions were less in LPS+rhEPO group than those in LPS+NS group 3 and 7 days after birth,while NS+rhEPO group and NS+NS group had no cerebral white matter lesions. The expressions of CD68 in LPS+rhEPO group,NS+rhEPO group,NS+NS group significantly decreased compared with LPS+NS group (F=7. 456,P<0. 01) 3 days after birth. The expressions of GFAP in LPS+rhEPO group,NS+rhEPO group,NS+NS group were lower than those in LPS+NS group (F=5. 121,P< 0. 01) 7 days after birth. Meanwhile,the expressions of MBP were not statistically different from the other groups 3 and 7 days after birth (F=2. 628,1. 425,all P>0. 05). No significant differences were found between LPS+rhEPO group and the other groups in evaluation of long-term neural development(all P>0. 05). The val-ues of F by the open field test,suspension test,slope hill test,and resistance to capture test were 2. 09,0. 53,0. 11,0. 37, respectively. Conclusions A single large dose (5 000 IU/kg) rhEPO has neuroprotective effect on the cerebral white matter lesions in the premature rats by inhibiting microglia and astrocyte activation in a short time. The long-term effort remains unknown.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal human cancers. Cur-rent studies on the relationship between complicated type 2 diabetes mellitus (T2DM) and PDAC prognosis have demonstrated inconsis-tent results. The present study aimed to determine the relationship between complicated T2DM and the clinicopathological characteris-tics of PDAC, and evaluate whether complicated T2DM is a significant predictor for overall survival in patients with resectable PDAC. Methods: In this study, clinicopathological characteristics were observed in 136 patients who underwent surgery for PDAC at the Shengjing Hospital of China Medical University between January 2009 and February 2011. The relationship between complicated T2DM and overall survival of PDAC patients was analyzed using univariate and multivariate analyses. Results:The median age of pa-tients was 60 years (range: 35-80 years). Among the 136 patients, 76(55.9%) were male. The prevalence of complicated T2DM was 27.9%in 136 PDAC cases. Preexisting T2DM was not associated with any of the clinicopathological characteristics (all P>0.05). Uni-variate analysis showed that complicated T2DM (P=0.045), maximum diameter (P=0.011), histological differentiation (P=0.013), pT stage (P=0.034), vessel invasion (P=0.032), and pTNM stage (P=0.030) were significantly associated with the overall survival of PDAC patients. The median overall survival time was 14.2 months for T2DM patients, and 18.8 months for non-T2DM patients. In mul-tivariate analysis, complicated T2DM [hazard ratio (HR), 1.873;95%confidence interval (CI), 1.187-2.954;P=0.007], poorly differenti-ated tumor (HR, 2.647;95%CI, 1.413-4.957;P=0.002), and maximum diameter≥4.0 cm (HR, 1.699;95%CI, 1.094-2.640;P=0.018) were the independent predictors associated with poor overall survival. Conclusion:Complicated T2DM was associated with poor prog-nosis. It could be used as a prognostic predictor in patients with resectable PDAC. If confirmed, these findings may provide a novel ap-proach for individualized adjuvant therapy.

Objective To investigate the clinical characteristics and high-risk factors of parenteral nutrition-associated cholestasis (PNAC) in very low birth weight infants (VLBWI),so as to guide the prevention and treatment of this condition.Methods A retrospective analysis was conducted with the data of 141 VLBWI collected from January 2013 to October 2014 in Affiliated Hospital of Qingdao University.These VLBWI were of gestational age ≤ 34 weeks and received parenteral nutrition (PN) for ＞ 14 days in Neonatal Intensive Care Unit.According to the existence of PNAC,they were divided into PNAC group (n =32) and non-PNAC group (n =109) and analyzed in terms of clinical features.Results Between the non-PNAC and the PNAC groups,univariate analysis showed significant differences in gestational age [(30.84 ± 1.55) weeks vs.(29.68 ±2.04) weeks,t=2.952,P=0.005],birth weight [(1 267.92±160.39) gvs.(1 050.63 ±229.74) g,t=6.064,P=0.000],hospital stay [(43.26 ±14.43) d vs.(66.47 ±22.25) d,t =-6.622,P=0.000],fasting time [(6.30±5.23) d vs.(11.94±7.92) d,t＝-4.723,P=0.000],PN duration [(32.40 ± 13.72) d vs.(57.59 ± 27.65) d,t =-7.039,P =0.000],the maximum daily dosage of amino acid [(3.61 ±0.27) g/ (kg·d) vs.(3.78±0.35) g/ (kg·d),t=-3.012,P=0.003];concurrent infection (56.88％ vs.87.50％,x2 =10.046,P =0.002),pneumonia (32.11％ vs.68.75％,x2 =13.790,P =0.000),necrotizing enterocolitis (0.92％ vs.9.38％,x2 =6.420,P =0.037),neonatal respiratory distress syndrome (55.05％ vs.78.13％,x2 =5.503,P =0.019),bronchopulmonary dysplasia (19.27％ vs.46.88％,x2 =9.918,P=0.002),congenital heart disease (4.59％ vs.21.88％,x2 =7.405,P =0.007);application of pulmonary surfactant (33.94％ vs.59.38％,x2 =6.682,P =0.010),continuous positive airway pressure ventilation (60.55％ vs.87.50％,x2 =8.085,P =0.004),mechanical ventilation (22.94％ vs.43.75％,x2 =5.356,P =0.021) and peripherally inserted central catheter (44.04％ vs.81.25％,x2 =13.737,P =0.000).Multivariate Logistic regression analysis revealed that PN duration was an independent high-risk factor of PNAC (B =0.069,OR =1.071,95％ CI =1.039-1.104,P =0.000).Conclusions Many factors are associated with PNAC,in which PN duration is an independent high-risk factor.Early enteral nutrition and shortened duration of PN may be protective measures for PNAC.

Objective To investigate the feasibility of mean wave intensity (MWI), W1 and W2 in assessing the function of common carotid artery (CCA) before and after cold presser test with wave intensity analysis. Methods Twenty-four healthy subjects were enrolled. The W1, W2, and other parameters of blood flow in resting, before and after cold presser test of CCA, the inner diameter different rate and MWI of blood flow were calculated respectively. The receiver operation characteristic (ROC) curves were drawn, and of the effectiveness of MWI, W1 and W2 was compared. Results The different rate of diameters and W1 decreased significantly when subjects underwent cold presser test (P＜0.05), but MWI and W2 increased significantly (P＜0.05). The area under ROC curves was 0.858, 0.731 and 0.698, corresponding to MWI, W1 and W2 (P＞0.05). Conclusion The function of CCA can be evaluated with MWI calculated from conventional parameters.