Objective To investigate the Clinical safety and effectiveness of propofol medium and long chain fat emulsion injection for cesarean section. Methods A retrospective analysis was conducted in 88 cesarean section surgeries performed between January, 2014 and June, 2015 with epidural anesthesia in 44 cases (control) and with total anesthesia with propofol/long chain fat emulsion injection in 44 cases (observation group). The maternal mean arterial pressure (MAP), SpO2, and heart rate and neonatal umbilical dynamic venous blood gas analysis (pH, PO2, pCO2) were compared between the two groups. Results Compared with the control group, heart rate and MAP significantly increased at skin incision in the observation group. At the other time points, heart rate, MAP, and SpO2 were all comparable between the two groups. The time from skin incision to newborn delivery was significantly shorter in observation group (P<0.05), but the time from uterine incision to delivery and neonatal Apgar score were equivalent between the two groups (P>0.05);neonatal umbilical arteriovenous blood pH, PO2, and pCO2 were all comparable between the two groups. Conclusion Propofol medium and long chain fat emulsion injection for general anesthesia induction in cesarean section is characterized by rapid metabolism of the anesthetics, rapid maternal postoperative recovery, and minimal adverse effects on the fetus, and is therefore safe and reliable in clinical use.

Objective To investigate the Clinical safety and effectiveness of propofol medium and long chain fat emulsion injection for cesarean section. Methods A retrospective analysis was conducted in 88 cesarean section surgeries performed between January, 2014 and June, 2015 with epidural anesthesia in 44 cases (control) and with total anesthesia with propofol/long chain fat emulsion injection in 44 cases (observation group). The maternal mean arterial pressure (MAP), SpO2, and heart rate and neonatal umbilical dynamic venous blood gas analysis (pH, PO2, pCO2) were compared between the two groups. Results Compared with the control group, heart rate and MAP significantly increased at skin incision in the observation group. At the other time points, heart rate, MAP, and SpO2 were all comparable between the two groups. The time from skin incision to newborn delivery was significantly shorter in observation group (P<0.05), but the time from uterine incision to delivery and neonatal Apgar score were equivalent between the two groups (P>0.05);neonatal umbilical arteriovenous blood pH, PO2, and pCO2 were all comparable between the two groups. Conclusion Propofol medium and long chain fat emulsion injection for general anesthesia induction in cesarean section is characterized by rapid metabolism of the anesthetics, rapid maternal postoperative recovery, and minimal adverse effects on the fetus, and is therefore safe and reliable in clinical use.

OBJECTIVETo investigate the Clinical safety and effectiveness of propofol medium and long chain fat emulsion injection for cesarean section.

METHODSA retrospective analysis was conducted in 88 cesarean section surgeries performed between January, 2014 and June, 2015 with epidural anesthesia in 44 cases (control) and with total anesthesia with propofol/long chain fat emulsion injection in 44 cases (observation group). The maternal mean arterial pressure (MAP), SpO(2), and heart rate and neonatal umbilical dynamic venous blood gas analysis (pH, PO(2), pCO(2)) were compared between the two groups.

RESULTSCompared with the control group, heart rate and MAP significantly increased at skin incision in the observation group. At the other time points, heart rate, MAP, and SpO(2) were all comparable between the two groups. The time from skin incision to newborn delivery was significantly shorter in observation group (P<0.05), but the time from uterine incision to delivery and neonatal Apgar score were equivalent between the two groups (P>0.05); neonatal umbilical arteriovenous blood pH, PO2, and pCO2 were all comparable between the two groups.

CONCLUSIONPropofol medium and long chain fat emulsion injection for general anesthesia induction in cesarean section is characterized by rapid metabolism of the anesthetics, rapid maternal postoperative recovery, and minimal adverse effects on the fetus, and is therefore safe and reliable in clinical use.

Anesthesia, Epidural ; Anesthesia, General ; Anesthetics ; therapeutic use ; Apgar Score ; Blood Gas Analysis ; Blood Pressure ; Cesarean Section ; Emulsions ; chemistry ; therapeutic use ; Fatty Acids ; chemistry ; therapeutic use ; Female ; Fetal Blood ; Fetus ; Heart Rate ; Humans ; Infant, Newborn ; Pregnancy ; Propofol ; therapeutic use ; Retrospective Studies