1.Placement of esophageal bed drainage with low negative pressure for early diagnosis and treatment of intra-thoracic esophageal anastomotic leakage
Journal of Medical Postgraduates 2017;30(1):88-90
Objective Anastomotic leakage is a serious complication after esophagectomy , we try to observe the early diag-nosis and treatment of intra-thoracic anastomotic leakage following esophagectomy through placing an esophageal bed drainage tube with low negative pressure on , and to explore the clinical value of esophageal bed drainage tube with low negative pressure . Methods We retrospectively analyzed the clinical data of 216 patients with esophageal carcinoma receiving intra-thoracic esophagogastro-anasto-mosis in our hospital from Mar .2013 to Nov.2015 .There were 124 patients were placed an esophageal bed drainage tube with low nega-tive pressure and a closed thoracic drainage tube after surgery ( low negative pressure group ) , and 92 patients were just place a closed thoracic drainange tube ( control group ) .Compared the differences of the incidence rate of intra-thoracic anastomotic leakage , the time of confirmed diagnosis and the time of recovery after anastomotic leakage ( time from confirmed diagnosis to recover oral intake ) between the two groups. Results There was no difference in incidences of anastomotic leakage in two groups (5.65%vs 4.34%, P>0.05), however, diagnosis of anastomotic leakage in experiment group was earlier than that of control group ([5.43±1.62]d vs [8.25±2.22]d, P<0.05) and the period of time for recovery after anastomotic leakage was shorter than control group ([29.29±10.18]d vs [78.50±20.27] d, P<0.05). Conclusion Placing a esophageal bed drainage tube with low negtive pressure in esophagectomy could be valuable for early diagnosis and treatment of anastomotic leakage as well as shorting the recovery course of anastomotic leakage after esophagectomy .
2.STUDIES ON THE ANTAGONISM OF 8601 AGAINST EXPERI-MENTAL EPILEPSY IN MICE
Cheng TAO ; Bo ZHENG ; Xiangfang ZHOU ; Shuyu WANG
Chinese Pharmacological Bulletin 1987;0(01):-
Cis-3, 4-dichloro -a-chloro-cinnamoyl-sec.-butylamine (8601), a new compound of cinnamamides, has potent antagonistic effect on experimental epilepsy. 8601 is significantly more effective against MES in mice than Antiepilepsirine. It has also been found effective against convulsion induced by icv. injection of sodium glu-tamate and zinc sulfate.The mechanisms of anti-MES of 8601 is related to content of 5 HT in the whole brain of mice. Increased cerebral 5 HT with L-tyrosine potentiated the effect of anti-MES of 8601,while the opposite was obtained using reserpine or pCPA which decreased the concentration of cerebral 5 HT. The increase of cerebral 5 HT is correlated with the effect of anti-MES of 8601 with a correlation coefficient of 0.926 ( P
3.Efficacy of comprehensive warming intervention strategy on gestational age <32 weeks preterm infants' body temperature during inter-hospital transportation
Zizhen WANG ; Liping CHENG ; Xiangfang REN ; Xiangyong KONG
Chinese Journal of Neonatology 2021;36(4):22-25
Objective:To study the effects of comprehensive warming intervention strategy on the body temperature of preterm infants (gestational age <32 weeks and birth weight <1 500 g) during inter-hospital transportation.Method:From October 2016 to July 2019, eligible preterm infants transported to our hospital were retrospectively analyzed. From October 2016 to March 2018, preterm infants transported with routine transportation strategy were assigned into the control group. From April 2018 to July 2019, preterm infants transported with the comprehensive warming intervention strategy were assigned into the experiment group. The body temperature, complications and prognosis before and after the transportation to our NICU were compared.Result:A total of 1 194 premature infants with gestational age <32 weeks were included with 630 cases in the control group and 564 cases in the experiment group. No significant differences existed in demographic data of the mothers, infants and the transportation time between the two groups ( P>0.05). The body temperatures before and after transportation in the experimental group were (36.8±0.5)℃ and (36.7±0.5)℃, significantly higher than the control group [(36.0±0.4)℃ and (36.3±0.6)℃] ( P<0.01). The incidences of hypoglycemia and mortality in the experimental group were 3.7% (21/564) and 4.8% (27/564), significantly lower than the control group [8.4% (53/630) and 7.9% (50/630)] ( P<0.05). Conclusion:Comprehensive warming intervention strategy in inter-hospital transport can effectively improve the body temperature of preterm infants before and after transportation, reducing the incidences of hypoglycemia and mortality.
4.Application of short message platform in nursing management in Neonatal in NICU
Mingxia SHANG ; Jianying DONG ; Liping CHENG ; Xiangfang REN
Chinese Journal of Modern Nursing 2014;20(12):1368-1370
Objective To explore the effect of short message platform on in nursing management in Neonatal Intensive Care Unit (NICU).Methods Short message platform was used in NICU to communicate with nurses.Time of information delivering , rate of message receiving , nurse’ awareness of message , meeting attendance rate and nurse ’ s satisfaction were compared before and after the application of short message platform to evaluate its effect .Results After the application of short message platform , the time of information delivering , rate of message receiving , nurse’ awareness of message and meeting attendance rate was respectively (0.04 ±0.15)min/message, (99.00 ±1.23)%, (98.00 ±1.23)% and (98.34 ±1.23)%, better than (3.12 ±1.20)min/message,(87.00 ±2.34)%,(88.00 ±2.23)%and(88.12 ±2.23)%before application, and the differences were statistically significant (t =13.95,-24.86,-21.74,-29.18, respectively; P<0.01).After application, nurse’ s satisfaction score of hospital management and the relationship between managers and nurses was respectively (2.79 ±0.99) and (4.50 ±0.64), higher than (2.03 ±0.74) and (4.12 ±0.56)before, and the differences were statistically significant (t=4.762 9,3.461 2, respectively;P<0.01).Conclusions Short message platform can shorten the time of message delivering , and improve the rate of message receiving, nurse’ awareness of message, meeting attendance rate as well as nurse ’s satisfaction, so as to improve nursing quality .The short message could be widely applied to nursing management due to its convenience , accuracy and quickness .