Objective:To investigate the status and influencing factors of psychological resilience of ophthalmic hospital Operating Room nurses, and to explore the correlation between psychological resilience and career development of Operating Room nurses.Methods:This is a cross-sectional study. From October to December 2021, 40 Operating Room nurses from Eye Hospital of Wenzhou Medical University were selected by convenience sampling method and investigated using general information questionnaire, Connor-Davidsion Resilience Scale (CD-RISC) and Career Development Questionnaire. Univariate analysis was used to explore the influencing factors of psychological resilience of Operating Room nurses. Pearson correlation analysis was employed to explore the correlation between psychological resilience and career development. A total of 40 questionnaires were distributed in this study, and 40 valid questionnaires were recovered, with an effective recovery rate of 100.0%.Results:The CD-RISC score of the Operating Room nurses was (90.40±9.27) , the score of Career Development Questionnaire was (112.5±9.65) . Univariate analysis results showed that age, professional title and working years were the influencing factors of psychological resilience of ophthalmic hospital Operating Room nurses ( P<0.01) . Pearson correlation analysis results showed that psychological resilience of Operating Room nurses was positively correlated with career development ( r=0.762, P<0.05) . Conclusions:The psychological resilience of ophthalmic hospital Operating Room nurses is at a medium level, and age, professional title and working years are its influencing factors. Operating Room nurses with high psychological resilience have better career development. Nursing managers should formulate personalized study and career plans, so as to promote nurses ' career development.