Objective:To study and design a new noninvasive equipment of measuring blood glucose on the basis of Raman spectrum,so as to realize noninvasively precise detection for blood glucose.Methods:This research specifically designed a dedicated Raman optical path and hardware circuit for entire machine through analyze and research the verification achievements of blood glucose measure equipment based on Raman spectrum.The Raman optical path included primary and secondary optical paths.The analysis of primary optical path was designed for both coaxial and off-axis modes,while the analysis of secondary optical path was designed with filters,slits,grating beam splitters and spectral integration modules.The hardware circuit integrated laser control module,spectrometer integration modules and general control modules.The above modules finally constituted special equipment with high sensitivity,which monitored the content of blood glucose by Raman spectrum.A total of 312 volunteers,who admitted to a Third-level grade-A hospital,were selected,and the biochemical analyzer and the noninvasive equipment of measuring blood glucose were adopted to conduct comparative test.Results:This researched noninvasive equipment of measuring blood glucose on the basis of Raman spectrum realized the function that detected blood glucose on finger belly by using Raman spectrum,which completed the product design for entire machine,and it can significantly reduce manufacturing cost of the noninvasive equipment of measuring blood glucose.In the comparative test for the 312 volunteers between noninvasive equipment of measuring blood glucose and biochemical analyzer,the detection error was less than 10%.Conclusion:The researched noninvasive equipment of measuring blood glucose can realize noninvasively precise detection for blood glucose through expands the number of test and iteration of software.