Objective To investigate the expression of IL-33,IL-37 in nasal polyps tissue,and their relevance to the pathogenesis of human nasal polyps. Methods Immunohistochemistry was used to detect the expression of IL-33,IL-37, in excisional nasal polyps tissue from 40 patients with nasal polyps. In addition,the expression of IL-33,IL-37 was also detected in normal nasal mucosa from 18 patients with the nasal septum deviation. Results In the nasal polyps tissues,IL-33 positive rate was 65.0%,IL-37 positive rate was 20.0%.In the normal nasal mucosa, IL-33 positive rate was 33.3%,IL-37 positive rate was 77.8%. Conclusion IL-33 and IL-37 play an important role in the pathogenesis of nasal polyps.