Objective:To analyze the research hotspots and trends ofintraosseous infusion at home and abroad, and to provide reference for clinical practice and nursing.Methods:Literature on intraosseous infusion from China National Knowledge Infrastructure and Web of Science were retrieved with a time limit of database establishment until December 31, 2023, and the research hotspots and trends were visually analyzed with VOSviewer software.Results:A total of 234 Chinese literatures and 633 English literatures were included, and the institutions with the highest publication volume were the Second Affiliated Hospital of Zhejiang University School of Medicine and the United States Department of Defense. The most frequently published journals were the Nursing Journal of Chinese People′s Liberation Army and Resuscitation. Domestic research focused on the application and nursing of intraosseous infusion in critically ill patients, puncture device, site, and comparison with intravenous infusion access; foreign research focused on aspects such as intraosseous infusion, cardiopulmonary resuscitation, vascular access, equipment, comparison with intravenous infusion access, complications, and pharmacokinetics.Conclusions:The overall number of publications on intraosseous infusion was on the rise, and there were both overlaps and differences in domestic and foreign research. In the future, we can learn from foreign research results to explore the appropriate treatment, management and nursing programs, while standardizing the operation process of intraosseous infusion, evaluating the best puncture site and equipment, establishing a talent training mechanism and system, and further enriching the professional construction of emergency teams.