TPX2(targeting protein for Xklp2)is a microtubule-associated protein in a new family of vertebrate spindle pole components.TPX2 is diffusely distributed all over the nucleus during the cell cycle phases S and G_2 and play important roles in mitotic spindle formation.TPX2 over expression was found in a variety of malignant tumors,that are asssociated with the centrosome amplification,aneuploidy,cell transfor- mation and the biological behavior of tumor.Blocking the expression of TPX2 can inhibit the growth of tumor cells.TPX2 may serve as a new candidate target for tumor therapy.The study progress of its structure and function,expression levels in cell cycle,molecular mechanism etc.was reviewed.

OBJECTIVE: To investigate the effects of Gypsum Fibrosum and Gypsum Fibrosum Preparatum in promoting granulation. METHODS: The wounds of muscle layer were produced in rats by using surgical operation. Two round wounds, with diameter about 1.5 cm, were cut at the depilatory area of two sides of the back of each rat, with an interval of 2 cm, deep to muscle layer, and the thickness of the knife wound of muscle layer was about 0.15 cm. Forty SD rats with the wounds were randomly divided into 4 groups: untreated group, beifuji-treated group, Gypsum Fibrosum-treated group and Gypsum Fibrosum Preparatum-treated group, with 10 rats in each group. Then the wounds were sprinkled with powders of Gypsum Fibrosum and Gypsum Fibrosum Preparatum, or sprayed with beifuji solution, respectively. The healing state of granulation tissues of the wounds was observed at the eighth and fourteenth day respectively. RESULTS: The number of fibroblasts, the number of capillary tubes and the area of capillary tubes in granulation tissue of wounds in the Gypsum Fibrosum Preparatum-treated group were significantly higher than those in the untreated group and Gypsum Fibrosum-treated group (P<0.01). There were no statistical differences between the Gypsum Fibrosum Preparatum-treated group and the beifuji-treated group. However, Gypsum Fibrosum-treated group showed no obvious differences compared to the untreated group (P>0.05). CONCLUSIONS: Gypsum Fibrosum Preparatum can accelerate the formation of collagenoblast and micrangium in wounds, and the proliferation of granulation tissues, thus promoting the skin wounds to healing. The effect of Gypsum Fibrosum is changed after being calcined, and Gypsum Fibrosum Preparatum has obvious effect in promoting granulation.

Adult ; Carbodiimides ; poisoning ; Humans ; Male ; Methylamines ; poisoning ; Occupational Exposure ; Young Adult

A retrospective study was made on the diagnosis and microsurgical management of 38 cases of cranial orbital tumors treated in our hospital in order to improve its clinical outcome. 29 males and 9 females with an age between 5 ～45 years (mean 32 2 years) were included in this series. 33 cases had their tumor located in anterior fossa, and 5 in middle fossa. 35(92 1%) cases showed malfunction of optic organs. 23(60 5%) cases had symptoms of intracranial hypertension. DSA and preoperative embolization of supplying arteries of tumors were performed in some cases. Microsurgical techniques and different approaches were used to remove tumors. 28 cases received total removal and others subtotal resection. No postoperative morbidity was found. 7 months～9 years follow up study showed that 24 cases resumed normal life, 6 had a dependent life and 5 had a certain recovery. One of the most frequent clinical manifestations of cranial orbital tumor was disorders in optic organs. The preoperative embolization of supplying arteries of tumors makes it possible to decrease bleeding during operation and increase the possibility to remove the total tumor. Microsurgical and piecemeal techniques as well as combined approaches may improve its clinical results.

Through a retrospective clinical analysis of 3160 cases of severe cranio cerebral injury ( SCCI ), the aim of this study is to explore effective treatments to increase cure rate for this injury. The causes and types of trauma, operation modalities,and prognosis were reviewed. The main causes resulting in SCCI were traffic accidents and fall from a height. The main types of SCCI were subdural, extradural and multiple intracranial hematomas. The main signs and symptoms were unconsciousness, pyramidal signs and pupil changes. The rate of cure and improvement was 73 6%. The mortality rate was 19 4%. Early diagnosis and timely operation, maintenance of patency of the respiratory tract, brain protection during operation, and competent ICU care after operation were important measure to achieve good recovery of SCCI patients.

To probe the treatment effects of the syringomyelia using microsurgical technique, a total of 127 patients with syringomyelia confirmed by CT or MRI in our department were analyzed retrospectively. The patients underwent occipitocervical decompression, syringostomy or syringo subarachnoid shunting (S S shunting) with microsurgery. All patients were followed up for more than 1 5 years and the treatment results were evaluated The results indicated that the collapse of the syrinx was achieved in 84 patients who underwent S S shunting or syringostomy. Decreased size of the syrinx was also noted in 43 Arnold Chiari malformation and spinal dysraphism patients who underwent occipitocervical decompression alone. The authors consider that the patients with syringomyelia should be microsurgically treated. The occipitocervical decompression, syringostomy or S S shunting may be an alternative method of surgical treatment for syringomyelia.

Objective To discuss the main features and experiences of surgical treatment of congenital spinal bifida and tethered cord syndrome. Methods Spinal bifida and tethered cord syndrome are congenital malformations. A study was conducted to analyse the morphology and the microsurgical operation of the diseases. During the Sept, 1993 to Feb, 2003, 528 patients were admitted to the hospital. The age ranged from 5 months to 45 years old (mean age 9 years). 239 cases(45.3%) were diagnosed as myelomeningocele, 123 cases(23.3%) were meningocele, 107 (20.3%) were spinal bifida with lipoma, and 59 cases of spinal bifida occulta (1.2%). Surgical removal of the arachnoid cyst and lipoma relieved compression of the spinal dural sac and the tethered spinal cord. Results Improvement was achieved in 322 cases (61%), no improvement in 194 cases (36.7%), and exacerbation of symptoms in 12 cases (2.3%). Conclusion Careful planning for the surgical treatment of spinal bifida is imperative. It is also important to release the compression tissues, in the spinal canal and to loosen the tethering.

Objective To evaluate the diagnosis and microsurgical treatment of intraspinal abscesses. Methods The clinical manifestations, diagnosis, and microsurgical treatment of sixty-two patients with intraspinal abscess were retrospectively analyzed. Among them, 36 were male and 26 were female, with an average age of 41 years. Thirty-seven were suffering from extradural abscesses, 23 subdural abscesses and 2 intramedullary abscesses. The diagnosis was made based on the history, clinical manifestations, MRI and myelogram. Prompt decompressive laminectomy and removal of the abscesses were carried out. Results Fifty-one patients were followed up. Of them, 27 completely recovered, accounting for 52.9%; in 18 the recovery was graded as good, accounting for 35.3%; and in 6 the recovery was fair, accounting for 11.8%. Conclusion Early diagnosis and microsurgical intervention of intraspinal abscesses could result in satisfactory recovery.

Objective To sum up the experiences in microneurosurgical treatment of spinal cord cavernous hemangiomas (SCH). Methods A retrospective analysis was made of 17 cases of SCH admitted from March 1992 to December 2002. Operations were performed via a posterior midline approach under a microscope. Results Total SCH resection was done in 13 cases, and subtotal removal in 4. The postoperative neurological status was improved in 11 cases, unchanged in 4, and aggravated in 2. No postoperative death occurred. Conclusion Spinal MRI examination is a reliable diagnostic method of SCH. Skillful microneurosurgical technique can achieve a rather good result.

Objective To study the effective methods of diagnosis and microsurgical treatment for tumors in spinal canal. Methods The diagnosis, treatment, and prognosis of 192 patients with spinal tumors admitted to our department ( from Jan,1992 to Dec,2002) were retrospectively analyzed. Results All the patients in this group underwent operative treatment. Total removal of tumor was achieved in 162 cases (84.4%), subtotal removal of tumor in 18 cases (9.4%), and removal a large portion of tumor with decompression in 12 cases (6.3%). Postoperatively, 163 patients (84.9%) were cured, the neurological symptoms were apparently improved in 27 patients (14.1% ), and unchanged in 2 patients (1.0%). No operative death occurred. Conclusion Early diagnosis and treatment of spinal tumor are important measures to improve prognosis. Imaging and microsurgery play a key role in the diagnosis and treatment of spinal tumors.