1.One new glycoside naphthopyranone from the Yiling cave-derived Metarhizium anisopliae NHC-M3-2
Li-man ZHOU ; Yi HAO ; Ju-xiang MENG ; Fang-fang QIN ; Qing-hua QIN ; Cong WANG ; Fan-dong KONG
Acta Pharmaceutica Sinica 2023;58(10):3076-3081
Seven compounds were isolated from fermentation extract of cave-derived
2.Insights of Chinese medicine syndrome study: from current status to future prospects.
Zhao-xiang BIAN ; Hao XU ; Ai-ping LU ; Myeong Soo LEE ; Hollie CHEUNG
Chinese journal of integrative medicine 2014;20(5):326-331
Syndrome differentiation is a key feature of Chinese medicine (CM) system. With CM receiving more and more attention from the mainstream medical systems, researchers from both traditional medical systems and the Western medical system are putting more effort into studying why and how the CM system works, particularly about CM syndromes. This paper reviews the current status of syndrome study and its future development. The major aspects include: (1) Usage of syndrome differentiation in clinical practice; (2) Formalization of syndrome diagnostic criteria; (3) Evidence-based determination of the common syndrome(s) of a disease; (4) Systems biology study of syndromes; and (5) Usage of syndrome in randomized controlled trials. It is expected to integrate the syndrome concept into the main stream medical system, in terms of diagnosis, treatment and prevention.
Humans
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Medicine, Chinese Traditional
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Syndrome
3.Probing into indication of living-related liver transplantation for Wilson's disease.
Feng CHENG ; Xue-Hao WANG ; Feng ZHANG ; Xiang-Cheng LI ; Guo-Qiang LI ; Bei-Cheng SUN ; Lian-Bao KONG
Chinese Journal of Surgery 2009;47(6):437-440
OBJECTIVETo probe into indication of living-related liver transplantation (LRLT) for Wilson's Disease.
METHODSFrom January 2001 to February 2007, thirty-seven living-related liver transplants were performed. A retrospective analysis was carried on outcome of those patients. The indications for LRLT were acute hepatic failure in 3 patients and chronic advanced liver disease in 32 patients including 13 patients with Wilsonian neurological manifestations. Two patients presented with severe Wilsonian neurological manifestations even though their liver functions were stable. According to the scoring system for evaluation of the neurological impairment in Wilson disease based on neurological signs and functions (total score was 30), the pre-transplantation score of those patients with neurological manifestations was 15.9 +/- 4.3 (n = 15).
RESULTSThirty-seven patients were followed up for 20 - 93 months. The survival rates of post-transplant patients and grafts at 1, 3, and 5 year were 91.9%, 83.8%, 75.7%, and 86.5%, 78.4%, 75.7%, respectively. Postoperative surgical complications occurred in 2 donors with bile leakage required drainage, in 2 recipients with hepatic thrombosis underwent retransplantation of cadaveric liver and in 1 recipient with hepatic stenosis required balloon dilatation. Neurological function was improved in all recipients and the score of posttransplantation at 6, 12, 18, 24, and 30 month was 17.5 +/- 3.7 (n = 13); 21.0 +/- 4.3 (n = 12); 23.9 +/- 3.9 (n = 10); 26.6 +/- 2.2 (n = 10) and 28.1 +/- 1.9 (n = 7) respectively.
CONCLUSIONSPatients with acute hepatic failure or patients with severe liver disease unresponsive to chelation treatment should be treated with LRLT. Early transplantation in patients with an unsatisfactory response medical treatment may prevent irreversible neurological deterioration even though their liver function is stable.
Adolescent ; Adult ; Child ; Female ; Follow-Up Studies ; Hepatolenticular Degeneration ; complications ; surgery ; Humans ; Liver Failure ; etiology ; surgery ; Liver Transplantation ; Living Donors ; Male ; Nervous System Diseases ; etiology ; Retrospective Studies ; Transplantation, Homologous ; Treatment Outcome ; Young Adult
4.Late recurrent high degree atrioventricular block after percutaneous closure of a perimembranous ventricular septal defect.
Rong YANG ; Yan-Hui SHENG ; Ke-Jiang CAO ; Jiang-Gang ZOU ; Hao ZHANG ; Xiao-Feng HOU ; Di XU ; Yong-Hong YONG ; Lei ZHOU ; Xiang-Qing KONG
Chinese Medical Journal 2011;124(19):3198-3200
High degree atrioventricular block (HDAVB) is a serious complication of transcatheter closure of a perimembranous ventricular septal defect (PMVSD). We report one patient who developed transient HDAVB seven days after transcathter closure of PMVSD and had recurrent HDAVB 42 months after the procedure.
Atrioventricular Block
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etiology
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Heart Septal Defects, Ventricular
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surgery
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Humans
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Male
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Middle Aged
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Postoperative Complications
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Recurrence
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Septal Occluder Device
5.Surgical methods in living donor liver transplantation: with report of 50 cases.
Xue-Hao WANG ; Feng ZHANG ; Xiang-Cheng LI ; Guo-Qiang LI ; Feng CHENG ; Bei-Cheng SUN ; Lian-Bao KONG ; Wen-Gang GE
Chinese Journal of Surgery 2006;44(21):1448-1452
OBJECTIVETo investigate and evaluate different surgical methods applied in living-donor liver transplantation (LDLT).
METHODSFifty patients with end-stage liver disease received LDLT in our department between January 1995 and March 2006. The data were analyzed on a retrospective basis. The choice of different surgical methods, strategies applied to ensure the safety of donors and indications of LDLT in the series were reviewed.
RESULTSAll donors recovered uneventfully. Among the 50 patients, 47 recipients presented with end-stage cirrhosis, 3 patients suffered from malignant tumor. To date, 6 recipients died after LDLT, among them, 3 recipients died of the operation and the other 3 recipients died of long-term complications. Resected donor livers included 9 cases of segments V, VI, VII and VIII (not including the middle hepatic veins) and 1 case of segments V, VI, VII and VIII (including the middle hepatic veins), 36 cases of segments II, III and IV (including the middle hepatic veins) and 4 cases of segments II, III, and part of IV (not including middle hepatic veins).
CONCLUSIONSLDLT helps tackle the problem of donor shortage in the world. The process is complicated, and it is very important to choose appropriate surgical methods for the improvement of surgical achievement and donor safety.
Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Infant ; Liver Cirrhosis ; surgery ; Liver Neoplasms ; surgery ; Liver Transplantation ; methods ; Living Donors ; Male ; Middle Aged ; Retrospective Studies
6.Adult living donor liver transplantation using right lobe for severe hepatitis in emergency: a report of 9 cases.
Feng ZHANG ; Xue-Hao WANG ; Xiang-Cheng LI ; Lian-Bao KONG ; Bei-Cheng SUN ; Guo-Qiang LI ; Xiao-Feng QIAN ; Feng CHENG ; Sen LU ; Ling LÜ
Chinese Journal of Surgery 2007;45(15):1019-1022
OBJECTIVETo evaluate the outcome of emergency adult right lobe living donor liver transplantation for fulminant hepatitis.
METHODSNine cases of adult right lobe living donor liver transplantation were performed from September 2002 to August 2005, the clinical and follow-up data was analyzed.
RESULTSAccording to Child Pugh Turcotte (CPT) classification, 9 patients were classified as grade C before transplant. The Model for End-Stage Liver Disease (MELD) scores of these patients were 26.7 +/- 8.8. The principal pre-transplant complications included hepatic encephalopathy (5 cases), electrolyte disturbance (3 cases), renal failure (2 cases), gastrointestinal bleeding (1 case). The operations in donors and recipients were all successful. The post-transplant complications induced pulmonary infection in 2 patients, acute renal failure in 3 and transplantation related encephalopathy in 1. There were no primary graft non-function and no blood vessel and bile tract complications occurred. One-year survival rate was 55.6%. No serious complication or death found in donors.
CONCLUSIONSEmergency adult to adult living donor liver transplantation is an effective treatment for fulminant hepatitis but the safety of the donors should be assessed strictly preoperation.
Adult ; Critical Illness ; Emergency Medical Services ; Female ; Follow-Up Studies ; Hepatitis ; pathology ; surgery ; Humans ; Liver Transplantation ; methods ; Living Donors ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome
7.An analysis on influencing factors of health literacy among residents of Chaoyang District,Beijing City
Qin XIAO ; Hui LIU ; Hao-Nan KONG ; Wei ZU ; Rui ZHANG ; Yan SUN ; Ming-Xiang GUO ; Min YANG
Journal of Preventive Medicine 2015;(8):793-796
Objective To analyze the status and influencing factors of health literacy among residents in Chaoyang District, Beijing City.Methods Through multi -stage stratified cluster sampling method in Chaoyang District,a total of 1 028 residents aged 1 6 to 69 years were selected.They were interviewed by using the questionnaire based on Chinese Citizens Health Literacy -Basic Knowledge and Skills (Trial)and modified by experts.Non -conditional logistic regression was used to evaluate the influencing factors of health literacy.Results The health literacy rate among the respondents was 21 .21 %.The health literacy rates of 7 issues including scientific view of health,safety and first aid,infectious diseases prevention,access to information and applications,basic medical care,chronic diseases prevention and daily health care were 59.05%,55.84%,41 .34%,27.53%,27.1 4%,1 0.31 % and 6.61 % respectively.The health literacy rates of basic knowledge and concepts,health lifestyle and behaviors with basic skills were 25.58%,1 8.09% and 32.20%respectively.The result of multiple logistic regression showed that living area and education level were the influence factors of health literacy.Conclusion According to the characteristics of living area and education level of residents,some measures should be carried out to improve the residents'health literacy,especially focused on the lifestyle and behavior intervention.
8.Relationship between C-reactive protein level and incidence of left atrial spontaneous echocardiographic contrast in patients with nonvalvular atrial fibrillation.
Zhi Feng LUO ; Xiang Yi KONG ; Chao JIANG ; Hao Jie ZHU ; Shuai ZHANG ; Jing CUI ; Tian Yi DAI ; Xin DU ; Jian Zeng DONG ; Chang Sheng MA
Chinese Journal of Cardiology 2020;48(3):223-227
Objective: To investigate the relationship between high sensitivity C-reactive protein (hs-CRP) level and incidence of left atrial spontaneous echocardiographic contrast (LASEC) in the patients with nonvalvular atrial fibrillation (AF). Methods: Four hundred and ninety consecutive patients with nonvalvular atrial fibrillation who underwent radiofrequency ablation for the first time from January 1, 2018 to June 30, 2018 in the Department of Cardiology, Beijing Anzhen Hospital were enrolled. According to the results of transesophageal echocardiography before radiofrequency ablation, patients were divided into the group without LASEC (n=338) and the group with LASEC (n=152). hs-CRP was determined by latex enhanced immunoturbidimetry. The relationship between hs-CRP and LASEC in patients with nonvalvular atrial fibrillation was investigated by univariate and multivariate logistic analysis. Results: LASEC was detected in 152 (31%) of 490 patients. Significant differences in age, type of atrial fibrillation, previous embolic events, fibrinogen, D-dimer, the left atrial anteroposterior diameter and CHA(2)DS(2)-VASc scores were found between patients with and without LASEC (all P<0.05). Compared with the group without LASEC, the serum hs-CRP level was significantly higher in the group with LASEC (3.16 (1.30, 5.23) mg/L vs. 0.67 (0.37, 1.48) mg/L, P<0.001). Multivariate logistic regression analysis showed that hs-CRP (OR=1.136, 95%CI 1.060 - 1.217, P<0.001) and D-dimer (OR=1.040, 95%CI 1.011 - 1.070, P=0.007) were independent determinants for LASEC in this patient cohort. Conclusions: hs-CRP is an independent determinant for LASEC in patients with nonvalvular atrial fibrillation. Inflammation may thus be involved in the formation of prethrombotic state in patients with nonvalvular atrial fibrillation.
Atrial Appendage
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Atrial Fibrillation/epidemiology*
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C-Reactive Protein
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Echocardiography, Transesophageal
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Electrocardiography
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Heart Atria
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Humans
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Incidence
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Risk Factors
9.Late recurrent high degree atrioventricular block after percutaneous closure of a perimembranous ventricular septal defect
Rong YANG ; Yan-Hui SHENG ; Ke-Jiang CAO ; Jiang-Gang ZOU ; Hao ZHANG ; Xiao-Feng HOU ; Di XU ; Yong-Hong YONG ; Lei ZHOU ; Xiang-Qing KONG
Chinese Medical Journal 2011;125(19):3198-3200
High degree atrioventricular block (HDAVB) is a serious complication of transcatheter closure of a perimembranous ventricular septal defect (PMVSD). We report one patient who developed transient HDAVB seven days after transcathter closure of PMVSD and had recurrent HDAVB 42 months after the procedure.
10.One case report of adjuvant antidepressant therapy with vitamin D and calcium
Hao SHI ; Xiaochun CHENG ; Lingquan KONG ; Liyuan MU ; Xiang ZHANG ; Yuanyuan WANG ; Hongyuan LI ; Guosheng REN ; Kainan WU
Chinese Journal of Endocrine Surgery 2024;18(4):591-592
Depression is a common mental illness in adolescents, and some patients do not respond well after medication, which may be partly related to vitamin D deficiency and insufficient calcium intake. This paper reports a 15-year-old patient with depression, whose condition was still unstable and the effect was not good despite routine use of antidepressant drugs and psychological intervention. After adequate supplementation of vitamin D and calcium, the patient's depression improved significantly, and the follow-up for 4 months, the condition was stable and did not recur.