Humans ; Kidney ; metabolism ; pathology ; Kidney Failure, Chronic ; metabolism ; therapy ; Kidney Transplantation ; Leptin ; metabolism ; Renal Replacement Therapy

LADA China Study is the first nation-wide muliicenter study for adult onset latent autoimmune diabetes (LADA) in Chinese.We have published the data on Diabetes in 2013.In this article,we briefly introduce the results and the significance to clinical practice.

Objective To evaluate the underlying causes of death of the in - patients with type 2 diabetes in Peking Union Medical College Hospital. Methods A cohort of 247 known dead in - patients with type 2 diabetes(132 men and 115 women) was identified from 1991 ～ 2003 in Peking Union Medical College Hospital. Underlying causes of death were obtained from death certificates and were coded according to the International Classifecation of Diseases (ninth revision). Results In our study, carduvascular disease was the most com-mon underlying cause of death and 110 death cases were attributable to it, and 64 to neoplasms,36 to respiratory disease, 14 to digestive disease, 10 to diabetes - related diseases, 1 to traffic accident cause, 13 to other natural causes. Conclusion This study confirms the im-portance of carduvascular disease as the major cause of death in people with type 2 diabetes. The evidence of an early effect on mortality suggests that prevention , early diagnosis, and treatment should be improved.

Anemia, Aplastic ; drug therapy ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; drug therapy ; Medicine, Chinese Traditional ; Phytotherapy

Objective To investigate the diagnosis and treatment. Of primary hyperthyroidism and concurrent thyroid microcarcinoma. Methods A retrospective analysis of 32 cases of primary hyperthyroidism and concurrent thyroid microcacinoma proved by postoperative pathology and were admilted between January 1994 and December 2002.Resulth The morbidity was 1.07%.No case had been diagnosed before operation.All of 32 cases underwent bilateral subtotal thyroidectomy.All cases showed diffase goiter and 11 cases showed small thyroid nodules at operation. There was no evidence of lymph node metastasis. No case had reoperation. No case of recurrent hyperthyroidism nor cancer was found during the 1 to 10 (mean5.5)years follow up. Conclusion The clinical diagnosis of primary hyperthyroidism and concurrent thyroid microcarcinoma is difficult and chiefly depends on postoperative pathology. Surgical treatment gives good results and has a better prognosis ,but long term follow up is still needed.

Objective To study the life span of Trichinella spiralis male adult and its effect on female fertility.Methods 22 Kunming mice were divided into three groups.Group A was orally inoculated by encysted larvae,dissected at day 5,10,20,and 30 post infection,adult worms were then collected and counted.Group B was fed with 5-day adults(70 females + 30 males/mouse).Group C was fed with 5-day females(70/mouse) only.Groups B and C were sacrificed 30 days post inoculation,larvae were collected to calculate reproductive capacity index(RCI).Male worms of day 5,10,20 and 30 were fixed in glutaraldehyde for scanning electron microscopy(SEM) and transmission electron microscopy(TEM).Results 20 days after infection,there were more males than females in the intestines of group A mice(female :male =1 :1.3),but much more males than females on the 30th day after infection(female :male =1 :8.5).Mice of groups B and C were infected by 5-day adults successfully with a RCI of 154.90?2.62 and 13.77?1.67 respectively(t=111.26,P

Schistosoma japonicum daughter sporocysts in Oncomelania tissue sections were, for the first time, used as antigen in the diagnosis of schistosomiasis japonica by indirect immunoperoxidase assay (IIPA-DS). The most strong peroxidase reaction was localized on the tegument of the daughter sporocysts and cercariae, and at some parts of cercariaf parenchyma, when IIPA-DS was carried out. Of 112 sera from proven cases of schisto-Bomiasis japonica, 106 (94.6%) were positive, the range of titre dilution was from 1:1 to 1:160, the geometrie mean of titres was 1:20. IIPA-DS highly coincided with IHA, COP and ELJSA in both sensitivity and strength of reaction. Sera from 101 blood donors and 24 normal rabbits were all negative. No cross reaction with sera from 24 patients with paragonimiasis was observed.

?AlM: To analyze the quantitative changes of anterior segment by Pentacam anterior segment system and to evaluate the safety and effectiveness after implantable collamer lens ( lCL) implantation for high myopia.
?METHODS:Twenty- one patients with 39 eyes were implanted lCL in our hospital from September 2011 to February 2013. The follow-up was 6 ~ 12mo. Central anterior chamber depth ( ACD ) , anterior chamber angle ( ACA) , anterior chamber volume ( ACV) were measured by Pentacam preoperatively, 1wk, 1 and 6mo postoperatively. The distance between crystal lens and lOL ( lCL- vault ) were measured at 1wk, 1 and 6mo postoperatively. Preoperative uncollected visual activity ( pre - UCVA ) , best corrected visual acuity ( BCVA ) , postoperative uncorrected visual acuity ( post-UCVA) and intraocular pressure ( lOP) were recorded. The paired t-test was used to access the data preoperatively and postoperatively in the statistical way by using SPSS 18. 0 statistical software.
? RESULTS: Preoperatively, at 1wk, 1 and 6mo postoperatively, ACD were 3. 27±0. 22, 3. 02±0. 33, 2. 98±0. 31, and 2. 98±0. 32mm. ACA were (40. 39±5. 40)o, (26. 70±4. 47)o, (26. 96±4. 48)o, and (26. 95±4. 45)o. ACV were 207. 74±25. 43, 122. 87±17. 58, 128. 05±17. 84, and 128. 64±17. 50mm3 , respectively. There were statistically significant differences between preoperative and postoperative data in ACD, ACA, ACV (P<0. 05). The distances between crystal lens and lOL ( lCL-vault) were 0. 49±0. 13, 0. 46±0. 13, and 0. 46±0. 14 at 1wk, 1 and 6mo postoperatively. There were statistically significant difference between 1wk and the others (P<0. 05). There were statistically significant different between the preoperative BCVA and postoperative BCVA(P<0. 05). There was no contact between lOL and the crystal len. The anterior chamber angle was all open. There were no serious complications such as cataract, glaucoma, cystoid macular edema, retinal detachment, etc.
?CONCLUSlON:ACD, ACA, ACV by Pentacam anterior segment system are found to be decreased after the operation, but there is still a relative safe distance between lOL and the crystal len. lCL implantation is a safe, efficacy method in correcting high myopia, but the long-term effects will require further observation.

TPX2(targeting protein for Xklp2)is a microtubule-associated protein in a new family of vertebrate spindle pole components.TPX2 is diffusely distributed all over the nucleus during the cell cycle phases S and G_2 and play important roles in mitotic spindle formation.TPX2 over expression was found in a variety of malignant tumors,that are asssociated with the centrosome amplification,aneuploidy,cell transfor- mation and the biological behavior of tumor.Blocking the expression of TPX2 can inhibit the growth of tumor cells.TPX2 may serve as a new candidate target for tumor therapy.The study progress of its structure and function,expression levels in cell cycle,molecular mechanism etc.was reviewed.

Benzamides ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; blood ; drug therapy ; Piperazines ; pharmacokinetics ; therapeutic use ; Pyrimidines ; pharmacokinetics ; therapeutic use