Optical coherence tomography angiography (OCTA) is a noninvasive angiography technique developed in recent years.Without using contrast medium,this technology can quickly and safely get retinal vascular images with relatively high-resolution.It has been widely used in the diagnosis and management of eye diseases,especially in the vascular diseases,such as diabetic retinopathy (DR),age-related macular degeneration (AMD),retinal central/branch venous obstruction (CRVO/BRVO),choroidal neovascularization(CNV),etc.This article reviews the clinical application of OCTA in diabetic retinopathy.

Diabetic cardiomyopathy is one of the main causes of death in diabetic patients.Mitochondrial dysfunction plays a key role in the development of diabetic cardiomyopathy,and mitochondrial function depends on the stabilization of the mitochondrial membrane structure.Studies on the molecular alteration and the underlying mechanism of the cardiocyte mitochondrial membrane of the diabetic heart may give us deeper insights into diabetic cardiomyopathy,and help us make a breakthrough in the therapeutic strategies.

Objective In order to meet the needs of Medicare patients, hospitals use existing network equipment to implement the connection with Data Center of Medicare without changing the present frame. Methods Network Address Translation function (NAT) was used to translate equipment IP address that hospital needs to connect with data center of Medicare into legal IP address in data center of medicare. Results The author used existing NAT function of equipment to reduce the repeating purchase for network equipment and successfully realized the connection between hospital and Data Center of Medicare. Conclusion Using NAT devices not only does not need to change the local IP address but effectively overcomes the lack of legal IP addresses, and what's more, network security is further strengthened.

The paper described the main function modules, system architecture, key technology and reservation business process of the appointment register platform system; security measure of the reservation platform system, as evidenced by the access of third-party payment interface, multi-tier data service, digital safety network among others which are designed to ensure the security and operability of the system.

Objective To explore the effects of postdischarge follow-up continuous nursing intervention on the psychological quality and compliance of immunosuppressants treatment in patients with kidney transplantation.Methods 157 patients with kidney transplantation post-operation were recruited,81 cases in the study group and 76 cases in the control group randomly.The control group received routine hospital discharge care and immunosuppressants treatment.The study group received postdischarge followup nursing intervention and immunosuppressants treatment.After 6 months of postdischarge intervention,the psychological quality of patients in two groups was assessed by the emotion application measure scale separately.The Morisky Medication Adherence Scale 8-item version (MMAS 8-item version) was used for the assessment of the immunosuppressants treatment compliance of the two groups of patients.Results After 6-month intervention,the patients in the study group showed better psychological quality than the patients in the control groups.There were significant differences in the various items of assessments of the psychological quality between the two groups.The high compliance percentage of immunosuppressants treatment of the study group was 45.7％,whereas the high compliance percentage of the control group was 22.4％.The differences between the two groups were significant.Conclusions Post-discharge follow-up nursing intervention to patients with kidney tranplantantion is effective for improving the psychological quality and the immunosuppressants treatment compliance and may be helpful to improve the life quality of the patients.

The paper conducts a case study of Tongji Medical College, Huazhong University of Science&Technology, introduces the application and management status of various cards, elaborates the one-card integration program for the management of staffs in the hos-pital and discusses the problems needing attention and the application effect.It is noted that the one-card solution facilitates the simpli-fication of the work process, the improvement of management efficiency and the reduction of management costs.

Objective To investigate the effects of pulmonary rehabilitation (PR) on the depression and exercises capacity and pulmonary function in elderly patients with stable moderate-to-severe chronic obstructive pulmonary disease. Methods 38 participants [(68.01 ± 5.27) years old; moderate 28, severe 10] were en-rolled in a 6-month PR program with exercise training. Subjects measurements were made of the Epidemiologic Studies Depression scale (CES-D), 6-minute walk test (6MWT) and pulmonary function. Result The CES-D Scores before and after PR were 23.94 ± 4.86 vs. 14.66 ± 2.47, P = 0.000; 6 MWT and the percent of the predicted FEV1 before and after PR were (353.6 ± 27.90)m vs. (276.8 ± 30.95)m, P = 0.000, 58.09 ± 8.77 vs. 58.34 ± 7.94, P > 0.05. CES-D scores and exercise capacity improved after PR. But PR contributes nothing to the improvement of pulmonary function. Conclusion Although the PR improves the depression and exercise capacity in elderly patients with stable moderate-to-severe COPD , no statistically significant correlation was ob-served between depression scores and 6MWD and the percent of the predicted FEV1.

Niemann-pick protein C1(NPC1) is a large integral membrane glycoprotein that resides in late endosomes,whereas niemann-pick protein C2(NPC2) is a small soluble protein found in the lumen of lysosomes.NPC1 protein is believed to facilitate the transport of lipids,particularly cholesterol,from late endosomes/lysosomes to the Golgi apparatus,endoplasmic reticulum and plasma membrane.NPC2 primarily plays a role in the egress of cholesterol and glycolipids from lysosomes.Mutations in either NPC1 or NPC2 result in aberrant lipid transport from endocytic compartments,which results in lysosomal storage of a complex mixture of lipids,primarily cholesterol and glycosphingolipids.The NPC proteins regulate sterol homeostasis through production of LDL cholesterol-derived oxysterols.Oxysterols are endogenous ligands for the liver X receptors(LXRs),which can upregulate ATP binding cassette transporter A1(ABCA1) expression.ABCA1 may have antiatherogenic effects through the efflux of it-mediated cholesterol.Meanwhile,NPC1 heterozygote mutation confers substantial resistance to lesional necrosis and lesional macrophage apoptosis.Study of the NPC proteins will help us for further understanding of the mechanisms involved in atherogenesis.

As one of important sorts of pesticides,organophosphorus pesticides(OPPs) are used widely in the world.They can cause serious environmental problems and have some adverse effects on the health of people and animals.They can induce acute neurotoxicity and delayed neurotoxicity,and result in the damages of organs.The objective of this paper is to provide a brief review of the mechanisms involved in the OPPs-induced hyperglycemia.OPPs can influence body glucose homeostasis by several mechanisms including oxidative stress,nitrosative stress,inhibition of cholinesterase,inhibition of paraoxonase,disturbance in metabolism of liver tryptophan and so on.

OBJECTIVE:To determine the concentration of ozagrel in human plasma by RP-HPLC.METHODS:The sample separation was performed on a SinoChrom OPS-AP column.The mobile phase consisted of 0.025 mol?L-1 potassium dihydrogen phosphate buffer solution-acetonitrile(85∶15) with a flow rate of 0.8 mL?min-1 and a detection wavelength of 274 nm.The internal standard was levodropropizine.RESULTS:The linear range of ozagrel was 0.7～21.3 ?g?mL-1,(r=0.999 6).The extraction recovery of ozagrel was 83.78%～89.14% and the methodological recovery of it was 101.95%～106.68%.The intra-day RSD and inter-day RSD were 1.33%～3.27% and 2.72%～5.97%,respectively.CONCLUSION:This method is simple,rapid,accurate and reproducible,and it is applicable for the pharmacokinetic study of ozagrel in human plasma.